Selected Group Publications

     

  1. Kang, TB., Yang, SH., Toth, B., Kovalenko, A. and Wallach, D. (2013). Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome. Immunity 38: 1-14.

  2. Dillon, C. P., Obserst, A., Weinlich, R., Janke, L. J., Kang, T. B., Ben-Moshe, T., Mak, T. W., Wallach, D. and Green, D. R. (2012). Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep. 1: 401-407.

  3. Wallach, D., Kovalenko, A., Kang, TB. (2011). "Necrosome"-induced inflammation: must cells die for it? Trends in Immunology, doi: 10.1016/j.it.2011.07.004.

  4. Rajput, A., Kovalenko, A., Bogdanov, K., Yang, SH., Kang, TB., Kim, JC., Du, JF., and Wallach, D. (2011). RIG-I RNA Helicase Activation of IRF3 Transcription Factor is Negatively Regulated by Caspase-8- Mediated Cleavage of the RIP1 protein. Immunity 34: 1-12.

  5. Kovalenko, A., Kim, JC., Kang, TB., Rajput, A., Bogdanov, K., Dittrich-Breiholz, O., Kracht, M., Brenner, O., and Wallach, D. (2009). Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J. Exp. Med. 206(10): 2161-77.

  6. Scharner D, Rössig L, Carmona G, Chavakis E, Urbich C, Fischer A, Kang TB, Wallach D, Chiang YJ, Deribe YL, Dikic I, Zeiher AM, Dimmeler S. (2009). Caspase-8 is involved in neovascularization-promoting progenitor cell functions. Arterioscler Thromb Vasc Biol. 29 (4): 571-8.

  7. Wallach, D., Kang, TB., Kovalenko, A. (2008). The extrinsic cell death pathway and the élan mortel. Cell Death Differ. 15(10): 1533-41.

  8. Kang TB, Oh GS, Scandella E, Bolinger B, Ludewig B, Kovalenko A, Wallach D. (2008). Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice. J Immunol. 181(4): 2522-32.

  9. Wallach, D. and Kovalenko, A. (2008). Self-termination of the terminator. Nat. Immunol. 9(12): 1325-7.

  10. Krelin, Y., Zhang, L., Kang, TB., Appel, E., Kovalenko, A., Wallach, D. (2008). Caspase-8 deficiency facilitates cellular transformation in vitro. Cell Death Differ. 15(9): 1350-5.

  11. Hövelmeyer, N., Wunderlich F.T., Massoumi, R., Jakobsen, C.G., Song, J., Wörns, M.A., Merkwirth, C., Kovalenko, A., Aumailley, M., Strand, D., Brüning, J.C., Galle, P.R., Wallach, D., Fässler, R. and Waisman, A. (2007). Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD. J. Exp. Med. 204(11): 2615-27.

  12. Ben Moshe, T., Barash, H., Kang, T.B., Kim, J.C., Kovalenko, A., Gross, E., Schuchmann, M., Abramovitch, R., Galun, E., and Wallach, D. (2007). Role of caspase-8 in hepatocyte response to infection and injury in mice. Hepatology 45(4): 1014-1024.

  13. Helfer, B., B. C. Boswell, Finlay, D., Cipres, A., Vuori, K., Kang, T.B., Wallach, D., Dorfleutner, A., Lahti, J.M., Flynn, D.C. and Frisch, S.M. (2006). Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions. Cancer Res 66(8): 4273-8.

  14. Kovalenko, A. and D. Wallach (2006). If the prophet does not come to the mountain: dynamics of signaling complexes in NF-kappaB activation. Mol Cell 22(4): 433-6.

  15. Schuchmann M, Ruckert F, Garcia-Lazaro JF, Karg A, Burg J, Knorr N, Siebler J, Varfolomeev EE, Wallach D, Schreiber W, Lohse AW and Galle PR. (2005) MORT1/FADD is involved in liver regeneration. World J Gastroenterol. 11: 7248-53.

  16. Wallach D. (2005). Probing cell death by chemical screening . Nat Chem. Biol. 1: 68-69.

  17. Ramakrishnan P, Wang W, and Wallach D. (2004). Receptor-specific signaling for both the alternative and the canonical NF-kB activation pathways by NF-kB-inducing kinase (NIK). Immunity, 21(3): 477-489.

  18. Kang T-B, Ben-Moshe T, Varfolomeev E E, Pewzner-Jung Y, Yogev N, Jurewicz A, Waisman A, Brenner O, Haffner R, Gustafsson E, Ramakrishnan P, Lapidot T and Wallach D (2004). Caspase-8 serves both apoptotic and non-apoptotic roles. J. Immunol. 173: 2976–2984.

  19. Kovalenko, A., Chable-Bessia, C., Cantarella, G., Israël, A., Wallach, D. and Courtois G. (2003). Tumor suppressor CYLD negatively regulates NF-kB signaling by deubiquitynation. Nature, 424: 801-805.

  20. Zhang, S. Q., Kovalenko, A., Cantarella, G,. and Wallach,  D. (2000). Recruitment of the I-kappa-B-kinase (IKK)  signalosome to the p55 TNF receptor: RIP and A20 bind  to NEMO (IKK gamma) upon receptor stimulation. Immunity, 12: 301-313.

  21. Wallach, D., Varfolomeev, E. E., Malinin, N. L., Goltsev, Y. V., Kovalenko A. V. and Boldin, M. P (1999). TNF receptor and Fas signaling mechanisms. Ann. Rev. Immunol., 17: 331-367.

  22. Watts, A. D., Hunt, N. H., Wanigasekara, Y., Bloomfield, G., Wallach,  D., Roufogalis, B. D., and Chaudhri G. (1999). A casein kinase I  motif present in the cytoplasmic domain of members of the  tumour necrosis factor ligand family is implicated in ‘reverse  signalling’. EMBO J., 118: 2119-2126.

  23. Wallach, D., Kovalenko, A. V., Varfolomeev, E. E. and Boldin,  M. P. (1998). Death-inducing functions of ligands of the  TNF family: a Sanhedrin verdict. Current Opin. Immunol., 10: 279-288.

  24. Varfolomeev, E. E., Schuchmann, M., Luria, V., Chiannilkulchai, N., Beckmann, J. S., Mett I. L., Rebrikov,  D., Brodianski, V. M., Kemper, O. C., Kollet, O., Lapidot,  T. S., Soffer, D., Sobe T., Avraham, K. B., Goncharov, T.,  Holtmann, H., Lonai, P. and Wallach, D. (1998). Targeted  disruption of the mouse caspase-8 gene ablates cell-death  induction by the TNF receptors, Fas/Apo1, and DR3 and is  lethal prenatally. Immunity, 9: 267-276.

  25. Goltsev, Y. V., Kovalenko, A. V., Arnold, E., Varfolomeev, E.  E., Brodianskii, V. M. and Wallach D. (1997). CASH, a novel caspase homologue with death effector domains. J. Biol.  Chem., 272: 19641-19644.

  26. Wallach, D. (1997). Cell death induction by TNF: a matter of self control. Trends Biochem. Sci., 22: 107-109.

  27. Malinin, N. L., Boldin, M. P., Kovalenko, A. V. and Wallach, D. (1997). MAP3K-related kinase involved in NF-kappa B  induction by TNF, CD95 and IL-1. Nature, 385: 540-544.

  28. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V. & Wallach, D. (1996). Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO1- and TNF receptor-induced cell death. Cell, 85: 803- 815.

  29. Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Mett, I. L., Camonis, J. H., and Wallach, D. (1995). A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chem., 270: 7795-7798.

  30. Nophar, Y., Kemper, O., Brakebusch, C., Engelmann, H., Zwang, R., Aderka, D., Holtmann, H. and Wallach, D. (1990).  Soluble forms of tumor necrosis factor receptors (TNF-Rs).  The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.  EMBO J., 9: 3269-3278.

  31. Engelmann, H., Holtmann, H., Brakebusch, C., Shemer-Avni, Y., Sarov, I., Nophar, Y., Hadas, E., Leitner, O. and Wallach. D. (1990).  Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.  J. Biol. Chem., 265: 14497-14504.

  32. Engelmann, H., Novick, D. and Wallach, D. (1990). Two tumor necrosis factor binding proteins purified from human urine.  Evidence for immunological cross reactivity with cell surface tumor-necrosis-factor receptors.  J. Biol. Chem. 265: 1531-1536.

  33. Hahn, T., Toker, L., Budilovsky, S., Aderka, D., Eshhar, Z. and Wallach, D. (1985). Use of monoclonal antibodies to a human cytotoxin for its isolation and for examining the self-induction of resistance to this protein.  Proc. Natl. Acad. Sci. USA, 82: 3814-3818.

  34. Wallach, D. (1984). Preparations of lymphotoxin induce resistance to their own cytotoxic effect.  J. Immunol. 132: 2464-2469.

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(A comprehensive list of the group's publications can be found here.)