Anti cancer treatment modality

Rosenbach-Belkin, V., L. Chen, L. Fiedor, F. Tregub, F. Pavlotsky, V. Brumfeld, Y. Salomon and A. Scherz (1996) Serine conjugates of chlorophyll and bacteriochlorophyll: phototoxicity in-vitro and tissue distribution in mice bearing melanoma tumors. Photochem. Photobiol. 64, 174-181.

Zilberstein, J., Bromberg, A., Franz, A.,Rosenbach-Belkin, V., Kritzmann, A., Pefferman, R., Salomon, Y. and Scherz, A. (1997) Light dependent oxygen consumption in bacteriochlorophyll-serine treated melanoma tumors: on-line determination using a tissue-inserted oxygen microsensor Photochem Photobiol. 65, 1012-1019.

Gross, S., Brandis, A., Chen, L., Rosenbach-Belkin, V., Roehrs, S. Scherz A. and Salomon, Y. (1997) Protein A mediated targeting of Bacteriochlorophyll-IgG to Staphylococcus aureus: a model for site-specific photocytotoxicity.Photochem. Photobiol. 66, 872-878.

Eichwurzel, I., Stiel, H., Teuchner, K.,. Leupold, D., Scheer, H., Salomon Y. and A. Scherz (2000) Photophysical consequences of coupling of bacteriochlorophyll a with serine and resulting solubility in water Photochem Photobiol. 72, 204-9.

Zilberstein, J., Schreiber, S., Bloemers, M.C.W.M., Bendel, P., Neeman, M., Schechtman, E., Kohen, F., Scherz, A., Salomon Y. (2001) Anti vascular treatment of solid melanoma tumors with bacteriochlorophyll-serine-based photodynamic therapy, Photochem. Photobiol. 73 257-263.

Chen, Q., Huang , Z., Luck, D., Beckers, J., Brun, PH., Wilson, BC., Scherz, A., Salomon, Y., & Fred W. Hetzel (2002) Preclinical studies in normal canine prostate of a novel palladium- bacteriopheophorbide photosensitizer (Tookad: WST09) for photodynamic therapy of prostate cancer Photochem.Photobiol. 76, 88-95.

Q. Chen, Z. Huang, D. Luck, J. Beckers, P. Brun, B. Wilson, A. Scherz, Y. Salomon and F. Hetzel. "WST09 (TOOKAD) mediated photodynamic therapy as an alternative modality in the treatment of prostate cancer" Proceedings of SPIE Vol 4612, 29-39, 200 2.

Schreiber S., Gross S.,, Brandis A., Harmelin A., Rosenbach-Belkin, V., Scherz A., and Salomon Y. (2002) Local Photodynamic Therapy (PDT) of rat C6 glioma xenografts with Pd-Bacteriopheophorbide Leads to Decreased Metastases and Increased Animal Cure Compared to Surgery. IntÕ J. Of Cancer, 99, 279-285.

Kelleher, D. K. Thews, O. Scherz, A. Salomon Y. and Vaupel P. (2003) Combined hyperthermia and chlorophyll-based photodynamic therapy: Tumour growth and metabolic microenvironment British J. of Cancer , 89, 2333-2339.

Preise, D., Mazor, O., Koudinova, N., Liscovitch, M., Scherz, A., and Salomon, Y., (2003), Bypass Of Tumor Drug Resistance By Antivascular Therapy, Neopliasia, 5, 475-48 0.

Gross. S, Gilead A. Scherz A. Neeman M. and Salomon Y.(2003) Monitoring Photodynamic Therapy of Solid Tumors Online by BOLD Contrast MRI, Nature Medicine, 9, 1327-1331.

Koudinova, N, Pinthus, J.H. , Brandis, A., Brenner, O., Bendel, P., Ramon J., Eshhar, Z., Scherz, A, Salomon, Y. (2003). Photodynamic therapy with Pd-bacteropheophorbid (TOOKAD): successful In vivo treatment of human prostatic small cell carcinoma xenograft. Intl. J. cancer Res 104, 782-789.

Z. Huang, Q. Chen, D. Luck, J. Beckers, P. Brun, B. C. Wilson, A. Scherz, Y. Salomon and F. W. Hetzel (2002) "Studies of Novel Photosensitizer TOOKAD for Treatment of Prostate Cancer" Proceedings of SPIE Vol 4952, 104-114.

Z. Huang, Q. Chen, P. Brun, B. C. Wilson, A. Scherz, Y. Salomon, D. Luck, J. Beckers and F. W. Hetzel (2003) "Studies of a novel photosensitizer Pd-bacteriopheophorbide (Tookad) for the prostate cancer PDT in canine model" Proceedings of SPIE Vol 5254, 83-90.

Kelleher DK, Thews O, Scherz A, Salomon Y., Vaupel P. (2004) Perfusion, oxygenation status and growth of experimental tumors upon photodynamic therapy with Pd-bacteriopheophorbide Int J Oncol. 24,1505-11.

Plaks, V., Koudinova, N., Nevo, U., Pinthus, J.H., Kanety, H., Eshhar, Z., Ramon, J., Scherz, A., Neeman M. and Salomon, Y. (2004) Photodynamic Therapy of Established Prostatic Adenocarcinoma with TOOKAD: A Biphasic Apparent Diffusion Coefficient Change as Potential Early MRI Response Marker Neoplasia 6, 224-233.

Plaks, V., Posen, Y., Mazor, O., Brandis, A., Scherz, A., and Salomon Y. (2004) Homologous adaptation to oxidative stress Induced by the photosensitized Pd-bacteriochlorophyll derivative (WST11) in cultured endothelial cells J. Biol. Chem. 44, 45713-45720.

Mazor O, Brandis A, Plaks V, Neumark E, Rosenbach-Belkin V, Salomon Y, Scherz A. (2005), WST11, A Novel Water-Soluble Bacteriochlorophyll Derivative; Cellular uptake, Pharmacokinetics, Biodistribution, and Vascular Targeted Photodynamic Activity Against Melanoma tumors.Photochem Photobiol.81(2):342-51.

Vilensky, J., Koudinova, N.V., Harmelin, A., Scherz, A. and Salomon Y. (2005) Vascular-Targeted PhotodynamicTherapy (VTP) of a Canine Transmissible Venereal Tumor in a Murine Model with Pd-bacteriopheophorbide (WST09). Vet. Comp. Oncol. Veterinary and Comparative Oncology 4, (3) 182-193.

Brandis A, Mazor O, Neumark E, Rosenbach-Belkin V, Salomon Y, Scherz A. (2005) Novel water-soluble bacteriochlorophyll derivatives for vascular-targeted photodynamic therapy: synthesis, solubility, phototoxicity, and the effect of serum proteins.Photochem Photobiol. 81, 983-993.

Fleshker, S., Preise, D., Kalchenko A., Scherz, A., and Salomon, Y., (2007). Prompt Assessment Of Wst11-Vtp Outcome Using Luciferase Transfected Tumors Enables Second Treatment And Increase In Overall Therapeutic Rate. Photochem. Photobiol. (in press).

Preise, D., Oren, R., Glinert, I., Kalchenko, V., Jung, S., Scherz A., and Salomon. Y. (2008). Systemic antitumor protection by vascular-targeted photodynamic therapy (VTP) involves cellular and humoral immunity. Cancer Immunology and immunotherapy. (In press).