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Life Sciences Open Day Book 2002

Table of Contents

Chapter 1. Genomics, Proteomics and Bioinformatics
Chapter 2. Proteins, Lipids and Membranes
Chapter 3. Plant Sciences
Chapter 4. Cell and Developmental Biology
Chapter 5. Cell Communication and Signal Transduction
Chapter 6. Cancer Research and Therapy
Chapter 7. Molecular Basis of Disease
Chapter 8. Immunology and Hematopoiesis
Chapter 9. The Nervous System and the Brain
Chapter 10. Services

Chapter 1. Genomics, Proteomics and Bioinformatics

Uri Alon Design principles of protein networks
Naama Barkai Analysis of biological networks
Eytan Domany Cluster analysis of biological data - gene expression and antigen reactivity
Marvin Edelman Structural bioinformatics: Approaches to molecular recognition
Miriam Eisenstein Development and application of theoretical tools for predicting the structures of molecular complexes
David Givol DNA microarray analysis of gene expression regulated by p53
Doron Lancet Molecular recognition and evolution in biological repertoires: From olfaction to the origin of life
Elisha Moses Enhanced imaging and detection using the electron microscope
Shmuel Pietrokovski Computational and experimental analysis of proteins - sequence to structure/ function relations
Amir Pnueli Modeling, simulation and analysis of C. elegans development
Ehud Shapiro Molecules and computation
Ada Yonath Antibiotics targeting ribosomes

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Chapter 2. Proteins, Lipids and Membranes

Yaakov Anglister Structure determination of proteins and their complexes by multidimensional NMR spectroscopy
Edward A. Bayer The high-affinity cohesin-dockerin interaction as a model for protein-protein biorecognition
Eitan Bibi Biogenesis, structure and function of membrane transport proteins
Roy Caplan An electrostatic mechnism closely reproducing observed behavior in the bacterial flagellar motor
Zvulun Elazar Mechanism of intracellular protein traffic
Deborah Fass Structure/function of protein-folding and protein-transport factors
Tony Futerman Sphingolipids as regulators of neuronal growth, development and death
Haim Garty Regulation of ion transport in the kidney
Gilad Haran Fluorescence imaging of the function and dynamics of single protein molecules
Amnon Horovitz Structural and functional aspects of allostery in chaperonins
Steven Karlish Structure, function and regulation of the cell membrane Na, K- pump
Ephraim Katchalski-Katzir Design and characterization of peptides that neutralize the venom of the snake Bungarus multicinctus
Uri Pick Molecular basis of salinity tolerance in the halotolerant alga Dunaliella
Ziv Reich Molecular machines: Structure, dynamics and therapeutics
Irit Sagi Studies of ECM invasion by cell-surface activated matrix metalloproteinases using infrared micro- spectroscopy
Gideon Schreiber Protein- protein interactions: From mechanism to protein design
Yechiel Shai Membrane proteins and their involvment in infectious diseases
Joel Stavans Single molecule elasticity studies of protein-DNA interactions in the bacterial nucleoid
Joel L. Sussman 3D structure-function of proteins involved in cholinergic neurotransmission
Dan Tawfik Man-made enzymes
Ada Zamir Molecular adaptations underlying the outstanding salt tolerance of the alga Dunaliella
Henryk Eisenberg Focal contributions to Life Sciences and Biophysics in the 20th century

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Chapter 3. Plant Sciences

Yuval Eshed Regulation of plant form - the role of boundaries

Moshe Feldman

Genetic and evolutionary studies in wheat
Robert Fluhr Sentinels of disease: Plant resistance genes
Gad Galili Regulation, functional significance and potential manipulation of lysine metabolism in plants
Gideon Grafi Cellular dedifferentiation: The perspective of chromatin structure
Avraham Levy The dynamic plant genome
Avigdor Scherz Photobiotechnology - from photosynthesis to cancer therapy

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Chapter 4. Cell and Developmental Biology

Abraham Amsterdam Control of differentiation and programmed cell death: The mammalian ovary as a model system
Michael Elbaum Biochemical machines of intracellular transport
Benjamin Geiger The molecular basis for cell adhesion
Jeffrey Gerst The molecular basis for cellular secretion: SNAREs, SNARE regulators, and secretory vesicles
Yoram Groner Gene dosage of Runx1 and Runx3 transcription factors: From Down Syndrome leukemia to neurogenesis
Atan Gross The role of BCL-2 family members and caspases in cell life and death
Chaim Kahana Regulation of intracellular polyamines, polycations that are essential for cellular viability and proliferation

Zvi Kam

Quantitative multidimensional light microscopy
Adi Kimchi Molecular networks controlling programmed cell death: DAP genes and beyond
Peter Lonai FGF signaling, extracellular matrix and development: Genetic studies
Abraham Minsky Ordered intracellular assemblies: A last-resort survival strategy
Elior Peles Molecular determinants of myelinated nerves
Shmuel Shaltiel Regulatory proteins and processes in blood: Kinases, vitronectin, PAI- 1 and PEDF
Benny Shilo Signaling by the Drosophila EGF receptor pathway during development
Meir Shinitzky Therapeutic and pathological signals of cell membranes
Alex Tsafriri The regulation of ovarian follicle growth, demise and the ovulatory response
Talila Volk Mechanisms controlling tissue assembly and morphogenesis in the developing embryo

Michael Walker

Specific gene expression in pancreatic beta cells

Anat Yarden

Bridging between the dynamics of biological discoveries and high-school biology education

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Chapter 5. Cell Communication and Signal Transduction

Alexander Bershadsky Interplay between adhesion-dependent signaling and the cytoskeleton
Fortune Kohen Anti-idiotypes and isoflavones as probes for estrogen action
Avihai Danon Redox signals in molecular adaptation
Nava Dekel Mechanisms involved in control of the meiotic cell cycle
Rivka Dikstein Characterization of subunits of the general transcription factor TFIID
Michael Eisenbach Chemotaxis: Communication strategies from bacteria to humans
Rony Seger Intracellular signaling cascades
Yoram Shechter Alternative pathways to manifest the metabolic bioeffects of insulin
David Wallach Regulation of cell-death and immune defense by receptors of the TNF/NGF family
Yosef Yarden Negative regulation of oncogenic signaling by receptor tyrosine kinases: Implications for cancer therapy
Yehiel Zick Transmembrane signaling: I. Molecular basis of insulin resistance. II. Regulation of cell adhesion and cell cycle progression by mammalian lectins
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Chapter 6. Cancer Research and Therapy

Avri Ben-Ze’ev The roles of b-catenin and plakoglobin in cell adhesion, transcription and oncogenesis
Hadassa Degani Breast and prostate cancer research; From molecular to in vivo imaging studies
Ari Elson Tyrosine phosphatase Epsilon - a multi-faceted regulator of physiological processes
Doron Ginsberg The E2F transcription factor as a regulator of cell proliferation
Moti Liscovitch Multidrug resistance in cancer: Role of caveolin, caveolae and lipid rafts
Michal Neeman Regulation of angiogenesis: Vascular growth, maturation and regression, permeability and lymphatic remodeling
Moshe Oren Understanding the role of p53 in cancer
Varda Rotter Expression of the wild type p53 tumor supressor gene in normal cells and its deregulation in cancer cells
Yoram Salomon Cancer therapy: Binary modes
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Chapter 7. Molecular Basis of Disease

Jacques S. Beckmann Analysis of genetic variation as a tool for the development of personalized medicine
Sara Fuchs Neurotransmitter receptors in health and disease
Alvin M. Kaye Interactions among steroid and peptide hormones in osteoporosis and breast cancer
Sima Lev The Nir proteins: From cellular functions to blindness
Zvi Livneh Molecular mechanisms of DNA repair and mutagenesis: From the origins of cancer to the basis of evolution
David Mirelman Molecular analyses of genes involved in the pathogenesis of Entamoeba histolytica
Uri Nudel The Duchenne muscular dystrophy gene: Structure, evolution, expression and function of products
Orly Reiner Lissencephaly, molecular elucidation of a human brain malformation
Michel Revel Demyelinating diseases and remyelination: Actions of interferon-b and of an interleukin-6 chimera
Yosef Shaul Molecular basis of virus-cell interaction and cell response
Meir Wilchek Allicin from garlic and its numerous applications for the benefit of Man
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Chapter 8. Immunology and Hematopoiesis

Ronen Alon The molecular basis of leukocyte adhesion to and migration through vascular endothelium
Ruth Arnon Copolymer 1 inhibits immune rejection
Avraham Ben-Nun Immunospecific approaches to therapy of autoimmune diseases: Multiple targeting of pathogenic autoreactivities
Gideon Berke The cytolytic T lymphocyte: Cognitive and effector functions in disease
Irun Cohen Autoimmune disease therapy, HSP60, immune regulation, antigen chips and bio- informatics
Lea Eisenbach From genomics to immunotherapy: Identifying tumor associated antigen peptides for anti-tumor vaccines
Zelig Eshhar Programming the nature of antibody and T cell receptor recognition
Tsvee Lapidot Human stem cell migration and development: Regulation by cytokines, chemokines and adhesion molecules
Ofer Lider Regulation of immune cell interactions with extracellular matrix during inflammation
Edna Mozes Specific immunomodulation of autoimmune diseases
Israel Pecht Recognition and signaling by immunoreceptors
Yair Reisner Transplantation across major genetic barriers
Menahem Rubinstein Regulation and function of cytokines and their binding proteins
Leo Sachs Stem cell biology: Molecular control of normal hematopoiesis, leukemia and apoptosis
Michal Schwartz Protective autoimmunity in acute and chronic CNS disorders: Therapeutic vaccines
Michael Sela Murine and human studies on the immunology of Copaxone (copolymer 1)
Idit Shachar The molecular mechanisms controlling development and function of immature B cells
Dov Zipori Regulation of hemopoiesis by the mesenchymal stroma: Role of cytokines and nuclear proteins

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Chapter 9. The Nervous System and the Brain

Ehud Ahissar Figuring space by time
Shabtai Barash Bridging body and mind: Neuronal signals, eye movements, brain architectures
Yadin Dudai The taste of memories: Mechanisms of learning, memory and forgetting in the mammalian brain
Mike Fainzilber Trophic signalling in the nervous system
Irith Ginzburg Tau-microtubule-associated-protein: Regulation of expression and axonal localization in neuronal cells
Amiram Grinvald Seeing the brain in action: exploring higher brain functions by optical imaging
Yitzhak Koch GnRH: A multifunctional neuropeptide
Rafael Malach Topography of human visual object areas revealed by functional magnetic resonance imaging
Henry Markram Neural microcircuits
Eitan Reuveny Gating and permeation of G protein coupled potassium channels
Dov Sagi Visual perception and psychophysics
Menahem Segal Morphological and functional plasticity in central neurons
Rabi Simantov Programmed neuronal death associated with neurodegeneration and drug abuse: Identifying novel genes
Vivian I. Teichberg Physiology and pathology of Glutamate-mediated neurotransmission in the brain
Zvi Vogel Signal transduction of drugs of abuse
Efraim Yavin Lipid molecules and signaling cascades during oxidative stress in the developing brain and neural cell cultures
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Chapter 10. Services

Genome Center and Biological Services
Chemical Services
Veterinary Resources
Yeda Research and Development Co. Ltd.

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