Life Sciences Open Day Book 2002
Chapter 1. Genomics, Proteomics and Bioinformatics
Chapter 2. Proteins, Lipids and Membranes
Chapter 3. Plant Sciences
Chapter 4. Cell and Developmental Biology
Chapter 5. Cell Communication and Signal Transduction
Chapter 6. Cancer Research and Therapy
Chapter 7. Molecular Basis of Disease
Chapter 8. Immunology and Hematopoiesis
Chapter 9. The Nervous System and the Brain
Chapter 10. Services
| Uri Alon | Design principles of protein networks |
| Naama Barkai | Analysis of biological networks |
| Eytan Domany | Cluster analysis of biological data - gene expression and antigen reactivity |
| Marvin Edelman | Structural bioinformatics: Approaches to molecular recognition |
| Miriam Eisenstein | Development and application of theoretical tools for predicting the structures of molecular complexes |
| David Givol | DNA microarray analysis of gene expression regulated by p53 |
| Doron Lancet | Molecular recognition and evolution in biological repertoires: From olfaction to the origin of life |
| Elisha Moses | Enhanced imaging and detection using the electron microscope |
| Shmuel Pietrokovski | Computational and experimental analysis of proteins - sequence to structure/ function relations |
| Amir Pnueli | Modeling, simulation and analysis of C. elegans development |
| Ehud Shapiro | Molecules and computation |
| Ada Yonath | Antibiotics targeting ribosomes |
| Yaakov Anglister | Structure determination of proteins and their complexes by multidimensional NMR spectroscopy |
| Edward A. Bayer | The high-affinity cohesin-dockerin interaction as a model for protein-protein biorecognition |
| Eitan Bibi | Biogenesis, structure and function of membrane transport proteins |
| Roy Caplan | An electrostatic mechnism closely reproducing observed behavior in the bacterial flagellar motor |
| Zvulun Elazar | Mechanism of intracellular protein traffic |
| Deborah Fass | Structure/function of protein-folding and protein-transport factors |
| Tony Futerman | Sphingolipids as regulators of neuronal growth, development and death |
| Haim Garty | Regulation of ion transport in the kidney |
| Gilad Haran | Fluorescence imaging of the function and dynamics of single protein molecules |
| Amnon Horovitz | Structural and functional aspects of allostery in chaperonins |
| Steven Karlish | Structure, function and regulation of the cell membrane Na, K- pump |
| Ephraim Katchalski-Katzir | Design and characterization of peptides that neutralize the venom of the snake Bungarus multicinctus |
| Uri Pick | Molecular basis of salinity tolerance in the halotolerant alga Dunaliella |
| Ziv Reich | Molecular machines: Structure, dynamics and therapeutics |
| Irit Sagi | Studies of ECM invasion by cell-surface activated matrix metalloproteinases using infrared micro- spectroscopy |
| Gideon Schreiber | Protein- protein interactions: From mechanism to protein design |
| Yechiel Shai | Membrane proteins and their involvment in infectious diseases |
| Joel Stavans | Single molecule elasticity studies of protein-DNA interactions in the bacterial nucleoid |
| Joel L. Sussman | 3D structure-function of proteins involved in cholinergic neurotransmission |
| Dan Tawfik | Man-made enzymes |
| Ada Zamir | Molecular adaptations underlying the outstanding salt tolerance of the alga Dunaliella |
| Henryk Eisenberg | Focal contributions to Life Sciences and Biophysics in the 20th century |
Chapter 3. Plant Sciences
| Yuval Eshed | Regulation of plant form - the role of boundaries |
| Genetic and evolutionary studies in wheat | |
| Robert Fluhr | Sentinels of disease: Plant resistance genes |
| Gad Galili | Regulation, functional significance and potential manipulation of lysine metabolism in plants |
| Gideon Grafi | Cellular dedifferentiation: The perspective of chromatin structure |
| Avraham Levy | The dynamic plant genome |
| Avigdor Scherz | Photobiotechnology - from photosynthesis to cancer therapy |
Chapter 4. Cell and Developmental
Biology
| Abraham Amsterdam | Control of differentiation and programmed cell death: The mammalian ovary as a model system |
| Michael Elbaum | Biochemical machines of intracellular transport |
| Benjamin Geiger | The molecular basis for cell adhesion |
| Jeffrey Gerst | The molecular basis for cellular secretion: SNAREs, SNARE regulators, and secretory vesicles |
| Yoram Groner | Gene dosage of Runx1 and Runx3 transcription factors: From Down Syndrome leukemia to neurogenesis |
| Atan Gross | The role of BCL-2 family members and caspases in cell life and death |
| Chaim Kahana | Regulation of intracellular polyamines, polycations that are essential for cellular viability and proliferation |
| Quantitative multidimensional light microscopy | |
| Adi Kimchi | Molecular networks controlling programmed cell death: DAP genes and beyond |
| Peter Lonai | FGF signaling, extracellular matrix and development: Genetic studies |
| Abraham Minsky | Ordered intracellular assemblies: A last-resort survival strategy |
| Elior Peles | Molecular determinants of myelinated nerves |
| Shmuel Shaltiel | Regulatory proteins and processes in blood: Kinases, vitronectin, PAI- 1 and PEDF |
| Benny Shilo | Signaling by the Drosophila EGF receptor pathway during development |
| Meir Shinitzky | Therapeutic and pathological signals of cell membranes |
| Alex Tsafriri | The regulation of ovarian follicle growth, demise and the ovulatory response |
| Talila Volk | Mechanisms controlling tissue assembly and morphogenesis in the developing embryo |
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Specific gene expression in pancreatic beta cells |
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| Bridging between the dynamics of biological discoveries and high-school biology education |
Chapter 5. Cell Communication and Signal Transduction
| Alexander Bershadsky | Interplay between adhesion-dependent signaling and the cytoskeleton |
| Fortune Kohen | Anti-idiotypes and isoflavones as probes for estrogen action |
| Avihai Danon | Redox signals in molecular adaptation |
| Nava Dekel | Mechanisms involved in control of the meiotic cell cycle |
| Rivka Dikstein | Characterization of subunits of the general transcription factor TFIID |
| Michael Eisenbach | Chemotaxis: Communication strategies from bacteria to humans |
| Rony Seger | Intracellular signaling cascades |
| Yoram Shechter | Alternative pathways to manifest the metabolic bioeffects of insulin |
| David Wallach | Regulation of cell-death and immune defense by receptors of the TNF/NGF family |
| Yosef Yarden | Negative regulation of oncogenic signaling by receptor tyrosine kinases: Implications for cancer therapy |
| Yehiel Zick | Transmembrane signaling: I. Molecular basis of insulin resistance. II. Regulation of cell adhesion and cell cycle progression by mammalian lectins |
Chapter 6. Cancer Research and Therapy
| Avri Ben-Ze’ev | The roles of b-catenin and plakoglobin in cell adhesion, transcription and oncogenesis |
| Hadassa Degani | Breast and prostate cancer research; From molecular to in vivo imaging studies |
| Ari Elson | Tyrosine phosphatase Epsilon - a multi-faceted regulator of physiological processes |
| Doron Ginsberg | The E2F transcription factor as a regulator of cell proliferation |
| Moti Liscovitch | Multidrug resistance in cancer: Role of caveolin, caveolae and lipid rafts |
| Michal Neeman | Regulation of angiogenesis: Vascular growth, maturation and regression, permeability and lymphatic remodeling |
| Moshe Oren | Understanding the role of p53 in cancer |
| Varda Rotter | Expression of the wild type p53 tumor supressor gene in normal cells and its deregulation in cancer cells |
| Yoram Salomon | Cancer therapy: Binary modes |
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Chapter 7. Molecular Basis of Disease
| Jacques S. Beckmann | Analysis of genetic variation as a tool for the development of personalized medicine |
| Sara Fuchs | Neurotransmitter receptors in health and disease |
| Alvin M. Kaye | Interactions among steroid and peptide hormones in osteoporosis and breast cancer |
| Sima Lev | The Nir proteins: From cellular functions to blindness |
| Zvi Livneh | Molecular mechanisms of DNA repair and mutagenesis: From the origins of cancer to the basis of evolution |
| David Mirelman | Molecular analyses of genes involved in the pathogenesis of Entamoeba histolytica |
| Uri Nudel | The Duchenne muscular dystrophy gene: Structure, evolution, expression and function of products |
| Orly Reiner | Lissencephaly, molecular elucidation of a human brain malformation |
| Michel Revel | Demyelinating diseases and remyelination: Actions of interferon-b and of an interleukin-6 chimera |
| Yosef Shaul | Molecular basis of virus-cell interaction and cell response |
| Meir Wilchek | Allicin from garlic and its numerous applications for the benefit of Man |
Chapter 8. Immunology and Hematopoiesis
| Ronen Alon | The molecular basis of leukocyte adhesion to and migration through vascular endothelium |
| Ruth Arnon | Copolymer 1 inhibits immune rejection |
| Avraham Ben-Nun | Immunospecific approaches to therapy of autoimmune diseases: Multiple targeting of pathogenic autoreactivities |
| Gideon Berke | The cytolytic T lymphocyte: Cognitive and effector functions in disease |
| Irun Cohen | Autoimmune disease therapy, HSP60, immune regulation, antigen chips and bio- informatics |
| Lea Eisenbach | From genomics to immunotherapy: Identifying tumor associated antigen peptides for anti-tumor vaccines |
| Zelig Eshhar | Programming the nature of antibody and T cell receptor recognition |
| Tsvee Lapidot | Human stem cell migration and development: Regulation by cytokines, chemokines and adhesion molecules |
| Ofer Lider | Regulation of immune cell interactions with extracellular matrix during inflammation |
| Edna Mozes | Specific immunomodulation of autoimmune diseases |
| Israel Pecht | Recognition and signaling by immunoreceptors |
| Yair Reisner | Transplantation across major genetic barriers |
| Menahem Rubinstein | Regulation and function of cytokines and their binding proteins |
| Leo Sachs | Stem cell biology: Molecular control of normal hematopoiesis, leukemia and apoptosis |
| Michal Schwartz | Protective autoimmunity in acute and chronic CNS disorders: Therapeutic vaccines |
| Michael Sela | Murine and human studies on the immunology of Copaxone (copolymer 1) |
| Idit Shachar | The molecular mechanisms controlling development and function of immature B cells |
| Dov Zipori | Regulation of hemopoiesis by the mesenchymal stroma: Role of cytokines and nuclear proteins |
Chapter 9. The Nervous System
and the Brain
| Ehud Ahissar | Figuring space by time |
| Shabtai Barash | Bridging body and mind: Neuronal signals, eye movements, brain architectures |
| Yadin Dudai | The taste of memories: Mechanisms of learning, memory and forgetting in the mammalian brain |
| Mike Fainzilber | Trophic signalling in the nervous system |
| Irith Ginzburg | Tau-microtubule-associated-protein: Regulation of expression and axonal localization in neuronal cells |
| Amiram Grinvald | Seeing the brain in action: exploring higher brain functions by optical imaging |
| Yitzhak Koch | GnRH: A multifunctional neuropeptide |
| Rafael Malach | Topography of human visual object areas revealed by functional magnetic resonance imaging |
| Henry Markram | Neural microcircuits |
| Eitan Reuveny | Gating and permeation of G protein coupled potassium channels |
| Dov Sagi | Visual perception and psychophysics |
| Menahem Segal | Morphological and functional plasticity in central neurons |
| Rabi Simantov | Programmed neuronal death associated with neurodegeneration and drug abuse: Identifying novel genes |
| Vivian I. Teichberg | Physiology and pathology of Glutamate-mediated neurotransmission in the brain |
| Zvi Vogel | Signal transduction of drugs of abuse |
| Efraim Yavin | Lipid molecules and signaling cascades during oxidative stress in the developing brain and neural cell cultures |
Chapter 10. Services
| Genome Center and Biological Services |
| Chemical Services |
| Veterinary Resources |
| Yeda Research and Development Co. Ltd. |