Publications

  1. Gil Friedman, Oshrat Levi-Galibov, Eyal David, Chamutal Bornstein, Amir Giladi, Maya Dadiani, Avi Mayo, Coral Halperin, Meirav Pevsner-Fischer, Hagar Lavon, Reinat Nevo, Yaniv Stein, H. Raza Ali, Carlos Caldas, Einav Nili-Gal-Yam, Uri Alon, Ido Amit, Ruth Scherz-Shouval. (2020). "Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome" Nat. Cancer, DOI:  https://doi.org/10.1038/s43018-020-0082-y

  2. Grunberg N, Levi-Galibov O, Scherz-Shouval R.  (2020). "The Role of HSF1 and the Chaperone Network in the Tumor Microenvironment.".  Adv Exp Med Biol. 2020;1243:101-111. DOI: 10.1007/978-3-030-40204-4_7.
  3. Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z. (2020). "A framework for advancing our understanding of cancer-associated fibroblasts." Nat Rev Cancer. 2020 Mar;20(3):174-186. DOI: 10.1038/s41568-019-0238-1.
  4. Miles J, Scherz-Shouval R, van Oosten-Hawle P. (2019). "Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response." Trends Biochem Sci., 44 (11): 927-942. DOI: 10.1016/j.tibs.2019.06.009.
  5. Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, and Bhatia SN. (2015). “Endothelial thermotolerance impairs nanoparticle transport in tumors”. Cancer Res., 75 (16): 3255-67. DOI: 10.1158/0008-5472.CAN-15-0325.
  6. Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L, and Lindquist S. (2014). “The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy”. Cell, 158 (3): 564-78. DOI: 10.1016/j.cell.2014.05.045. See also preview: Nat. Rev. Cancer, 2014; 14 (9): 579. DOI: 10.1038/nrc3807.
  7. Kithsiri Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, and Leslie Gunatilaka AA. (2014). “Structure-activity relationships for withanolides as inducers of the cellular heat-shock response”. J. Med. Chem., 57 (7): 2851-63. DOI: 10.1021/jm401279n.
  8. Vincent BM, Lancaster AK, Scherz-Shouval R, Whitesell L, and Lindquist S. (2013). "Fitness trade-offs restrict the evolution of resistance to amphotericin B”. PLOS Biol., 11 (10): e1001692. DOI: 10.1371/journal.pbio.1001692.
  9. Scherz-Shouval R, and Elazar Z. (2011). “Regulation of autophagy by ROS: physiology and pathology”. Trends Biochem. Sci., 36 (1): 30-8. DOI: 10.1016/j.tibs.2010.07.007.
  10. Scherz-Shouval R, Weidberg H, Gonen C, Wilder S, Elazar Z and Oren M. (2010). “p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation”. Proc. Natl. Acad. Sci. U.S.A., 107 (43): 18511-6. DOI: 10.1073/pnas.1006124107.
  11. Scherz-Shouval R, and Elazar Z. (2009). “Monitoring starvation-induced reactive oxygen species formation”. Methods Enzymol., 452: 119-30. DOI: 10.1016/S0076-6879(08)03608-2.
  12. Shvets E, Fass E, Scherz-Shouval R, and Elazar Z. (2008). “The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes”. J. Cell Sci., 121 (16): 2685-95. DOI: 10.1242/jcs.026005.
  13. Scherz-Shouval R, and Elazar Z. (2007). “ROS, mitochondria and the regulation of autophagy". Trends Cell Biol., 17 (9): 422-7. DOI: 10.1016/j.tcb.2007.07.009.
  14. Scherz-Shouval R, Shvets E, and Elazar Z. (2007). “Oxidation as a post-translational modification that regulates autophagy”. Autophagy, 3 (4): 371-3. DOI: 10.4161/auto.4214.
  15. Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, and Elazar Z. (2007). “Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4”. EMBO J., 26 (7): 1749-60. DOI: 10.1038/sj.emboj.7601623. See also preview: Dev. Cell, 2007; 12 (4): 484-5. DOI: 10.1016/j.devcel.2007.03.016.
  16. Elazar Z, Scherz-Shouval R, and Shorer H. (2003). "Involvement of LMA1 and GATE-16 family members in intracellular membrane dynamics". Biochim. Biophys. Acta, 1641 (2-3): 145-56. DOI: 10.1016/S0167-4889(03)00086-7.
  17. Scherz-Shouval R, Sagiv Y, Shorer H, and Elazar Z. (2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J. Biol. Chem., 278 (16): 14053-8. DOI: 10.1074/jbc.M212108200.
  18. Scherz R, Shinder V, and Engelberg D. (2001). "Anatomical analysis of Saccharomyces cerevisiae stalk-like structures reveals spatial organization and cell specialization". J. Bacteriol., 183 (18): 5402-13. DOI: JB.183.18.5402-5413.2001.