Plasticity at the organism level

Our model for plasticity in vivo is based on a synthetic drug/anti-drug system for confronting fly larvae with artificially determined patterns of toxicity. These patterns are created by feeding the larvae with a toxic antibiotic (G418) at concentrations that are lethal to wild-type larvae.

Plasticity at the cellular level

At the cellular level we use embryonic stem cell models (ESCs) to investigate the regulation of developmental potential during early stages of ESC differentiation. ESCs are highly plastic cells, capable of self-renewal and differentiation towards all cellular lineages.