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telephone: 972-8-940-7183 fax: 972-8-940-7443 e-mail: avraham.patchornik@weizmann.ac.il
M. Fridkin, A. Patchornik and E. Katchalski. A synthesis of cyclic peptides utilizing high molecular weight carriers. J. Am. Chem. Soc. 87, 4646 (1965).
M. Fridkin, A. Patchornik and E. Katchalski. Use of polymers at cysteinyl residues. J. Am. Chem. Soc. 88, 3164 (1966).
M. Fridkin, A. Patchornik and E. Katchalski. Use of insoluble active amino acid derivatives in the synthesis of bradykinine. Proc. XXXVI Isr. Chem. Soc. 4, 59 (1966).
F. Bondi, M. Fridkin and A. Patchornik. The use of polymeric carriers in the synthesis of cyclic peptides containing S-S bonds. Isr. J. Chem. 6, 22 (1968).
M. Fridkin, A. Patchornik and E. Katchalski. Use of polymers as chemical reagents. II. Synthesis of bradykinin. J. Am. Chem. Soc. 90, 2953 (1968).
M. Fridkin, A. Patchornik and E. Katchalski. Peptide synthesis by means of tert-butyloxycarbonyamino acid derivatives of poly(ethylene-CO-N-hydroxymaleimide). Biochemistry 11, 466 (1972).
R. Kalir, M. Fridkin and A. Patchornik. (4-Hydroxy-3-nitro)benzylated polystyrene. An improved polymeric nitrophenol derivative for peptide synthesis. Eur. J. Biochem. 42, 151 (1974).
D. Atlas, R. Kalir and A. Patchornik. Synthesis of peptide substrates for porcine elastase via (4-hydroxy-3-nitro)benzylated polystyrene (PHNB). FEBS Lett. 48, 179 (1975).
R. Kalir, A. Warshawsky, M. Fridkin and A. Patchornik. New useful reagents for peptide synthesis. Insoluble active esters of polystyrene-bound 1-hydroxybenzotriazole. Eur. J. Biochem. 59, 55 (1975).
A. Patchornik, Y. Shai and S.H. Pass. Method for multipolymer synthesis of organic compounds. U.S.A. Patent 4,552,922, Nov. 12, 1985.
A. Patchornik. Synthesis using polymeric reagents. Chemtech. 58-63, January 1987.
B. Amit and A. Patchornik. The photorearrangement of N-substituted ortho-nitroanilides and nitroveratramides. A potential photosensitive protecting group. Tetrahedron Lett. 24, 2205 (1973).
B. Amit, U. Zehavi and A. Patchornik. Photosensitive protecting groups of amino sugars and their use in glycoside synthesis. 2-nitrobenzyloxcarbonylamino and 6-nitroveratryloxycarbonylamino derivatives. J. Org. Chem. 39, 192 (1974).
B. Amit, U. Zehavi and A. Patchornik. Photosensitive protecting groups - a review. Isr. J. Chem. 12, 103 (1974).
M. Rubinstein, B. Amit and A. Patchornik. The use of light-sensitive phosphate protecting group for some mononucleotide syntheses. Tetrahedron Lett. 17, 1445 (1975).
B. Amit, D. Ben-Efraim and A. Patchornik. Light-sensitive amides, the photosolvolysis of substituted 1-acyl-7-nitroindolines. J. Am. Chem. Soc. 98, 843 (1976).
B. Amit, E. Hazum, M. Fridkin and A. Patchornik. A photolabile protecting group for the phenolic hydroxyl function of tyrosine. Int. J. Pept. Prot. Res. 8, 91 (1977).
A. Patchornik, K.A. Jacobson and M.P. Strubb. Photoreversible affinity labeling. Presented at the 18th Int. Solvay Conf., Brussels, Belgium, November 1983.
M. Segal and A. Patchornik. Modulation of [Ca]i by a caged EGTA affects neuronal plasticity in the rat hippocampus. Abstract, 19th Ann. Neurosci. Meeting, Pheonix Arizona, October 1989.
A. Patchornik, W.B. Lawson, E. Gross and B. Witkop. The use of N-bromosuccinimide and N-bronoacetamide for the selective cleavage of C-tryptophyl peptide bonds in model peptides and glucogon. J. Am. Chem. Soc. 82, 5923 (1960).
S. Shaltiel and A. Patchornik. Cleavage of histidyl peptide bonds by N-bromosuccinimide. J. Am. Chem. Soc. 85, 2799 (1963).
S. Shaltiel and A. Patchornik. Differentiation between tryptophyl, tyrosyl and histidyl peptide bonds on cleavage with N-bromosuccinimide. Isr. J. Chem. 1, 64 (1963).
M. Sokolovsky and A. Patchornik. Selective cleavage of the eight cysteinyl peptide bonds in ribonuclease. Isr. J. Chem. 1, 215 (1963).
T.F. Spande, B. Witkop, Y. Degani and A. Patchornik. Selective cleavage and modification of peptides and proteins. In "Advances in Protein Chemistry" Vol. 24, Academic Press, N.Y. (1970).
Y. Burstein and A. Patchornik. Selective chemical cleavage of tryptophenyl peptide bonds in peptides and proteins. Biochemistry 11, 4641 (1972).
Y. Degani and A. Patchornik. Cyanylation of sulfhydryl groups by 2-nitro-5-thiocyanobenzoic acid. High-yield modification and cleavage of peptides at cysteine residues. Biochemistry 13, 1 (1974).
Y. Shechter, A. Patchornik and Y. Burstein. Selective chemical cleavage of tryptophenyl peptide bonds by oxidative chlorination with N-chlorosuccinimide. Biochemistry 15, 5071 (1976).
Research Projects:
I. Uses of Polymeric Reagents in Peptide Synthesis
II. Personal project on the History of Nes Tziyona
General Comments
Should you have any request or questions or you would like to consult me on how to use
the techniques described in the following references, or to obtain samples of reagents,
e.g. in the category Universal Standard Reagents, please don't hesitate to contact me - all is free of charge. A.P.
II. Analytical Chemistry Using Universal Standard Reagents
III. Use of Photosensitive Blocking Groups
A. Patchornik, B. Amit and R.B. Woodward. Photosensitive protecting groups. J. Am. Chem. Soc. 92, 6333 (1970).IV. Selective Non-Enzymatic Degradation of Proteins and Peptides at Selected Sites
A. Patchornik, W.B. Lawson and B. Witkop. Selective cleavage of peptide bonds. II. The tryptophyl peptide bond and the cleavage of glucagon. J. Am. Chem. Soc. 80, 474 (1958).