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Founding president, Israel Society for Combinatorial Technologies(ISCT) Deceased November 12, 2001 (26 Marheshvan 5762)The late Rebecca and Israel Sieff Professor
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Members of the group:
Nava Kahana, Ph.D nava.kahana@weizmann.ac.il
Ying Wang, Ph.D. ying.wang@weizmann.ac.il
Mark Vilensky mark.vilensky@weizmann.ac.il
Chengyo Wang, Ph.D. visiting scientist
Ehud Schehori, Ph.D. consultant - polymers, plastics, membranes
Gary Gellerman, Ph.D. consultant - combinatorial chemistry gary@peptor.co.il
Research interests of the late Warshawsky Group
Metal Complexing Ligands, Polymers, Membranes: Synthesis, Biological and Ecological Applications
Synthesis and activity of metal binding ligands and polymers:
- (a) drugs, to reduce the level of toxic radicals
- (b) Synergizing the action of herbicides; copper- and iron-selective metal binders, e.g., for the treatment of Parkinson's disease
- (c) Synthesis of herbicides: amino acid analogs using polymeric catalysts
- (d) Metal complexing polymers: fundamental and applied studies to remove toxic metal ions
- (e) Active pseudohomogenous catalysts for fixation of CO2.
- (f) Hydrogen storage in chemically stored forms
- (g) Polymer catalyzed isotope exchange
- (h) Active functional membranes: photochromic membranes, diagnostic membranes
- (i) Combinational technologies: polymeric active drugs in cancer diagnosis; polymer-supported reagents for synthesis of organophosphorous neurotransmitters
- (j) Biologically active phospholipids and organophosphorous extractants
Combinatorial Chemistry Course Syllabus
Recent publications
Y. Wang, C. Y. Wang, A. Warshawsky, and B. Berkowitz
8-hydroxyquinoline-5-sulfonic acid (HQS) impregnated on Lewatit MP 600 for cadmium complexation: Implication of solvent impregnated resins for water remediation
SEPAR SCI TECHNOL 38 (1): 149-163 2003I. Rogachev, C. Serra, A. Farran, JL. Cortina, J. Gressel, and A. Warshawsky, Prediction of the octanol-water distribution of dithiocarbamate derivatives
REACT FUNCT POLYM 54 (1-3): 17-24 2003 [read online]J. L. Cortina, A. Warshawsky, N. Kahana, V. Kampel, C. H. Sampaio, and R. M. Kautzmann
Kinetics of goldcyanide extraction using ion-exchange resins containing piperazine functionality
REACT FUNCT POLYM 54 (1-3): 25-35 2003 [read online]J. Gressel, D. Michaeli, V. Kampel, et al.
Ultralow calcium requirements of fungi facilitate use of calcium regulating agents to suppress host calcium-dependent defenses, synergizing infection by a mycoherbicide
J AGR FOOD CHEM 50 (22): 6353-6360 OCT 23 2002 [read online]Y. Wang, A. Warshawsky, C. Y. Wang, et al.
Fluorescent ultrahigh-molecular-weight polyacrylamide probes for dynamic flow systems: Synthesis, conformational behavior and imaging
MACROMOL CHEM PHYSIC 203 (12): 1833-1843 AUG 30 2002 [read online]A. Warshawsky, A. G. Strikovsky, M. Y. Vilensky, et al.
Interphase mobility and migration of hydrophobic organic metal extractant molecules in solvent-impregnated resins
SEPAR SCI TECHNOL 37 (11): 2607-2622 2002MY. Vilensky, B. Berkowitz, and A. Warshawsky
In situ remediation of groundwater contaminated by heavy- and transition-metal ions by selective ion-exchange methods
ENVIRON SCI TECHNOL 36 (8): 1851-1855 APR 15 2002 [read online]A. Warshawsky A, A. G. Strikovsky, F. N. Fernandez, et al.
Synthesis of novel chelating resins containing dithiophosphoric functionality and comparison to analogous solvent impregnated resins
SEPAR SCI TECHNOL 37 (4): 823-846 2002A. Warshawsky, G. Marquès, N. Kahana, V. Kampel, J.L. Bourdelande and M. Valiente. 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) covalently bound to a polysulfone and to an insoluble polystyrene: synthesis and applications to the selective adsorption of Ca2+ from Mg2+ in water. Macromol. Chem. Phys. 202, 2659 (2001).[read online]
Y. Wang, S. Astilean, G. Haran, A. Warshawsky. Microenviromental investigation of polymer-bound fluorescent chelator by fluorescence microscopy and optical spectroscopy. Anal. Chem.,73, 4096 (2001). [read online]
D. Muraviev, V. Gorshkov and A. Warshawsky. Special issue on stable isotopes: Fractionation and isotope exchange. Highlights of Russian science - Foreword. Separ. Sci. Technol. 36, vii (2001). [read abstract]
D. Muraviev and A. Warshawsky. Aqua-impregnated resins as new dual-function deuterating agent. Separ. Sci. Technol. 36, 2087 (2001).[read abstract]
A. Warshawsky, N. Kahana, V. Kampel, I. Rogachev, R. M. Kautzmann, J. L. Cortina, C. H. Sampaio. Ion exchange resins for goldcyanide extraction containing a piperazine funcionality. Part 2. Extraction studies of gold(I) from cyanide solutions. Macromole. Mat. Eng., 286, 285 (2001).[read online]
A. Warshawsky, I. Rogachev, Y. Patil, A. Baszkin, L. Weiner and J. Gressel. Copper-specific chelators as synergists to herbicides: Part 1. Amphiphilic dithiocarbamates, synthesis, transport through lipid bilayers and inhibition of Cu/Zn superoxide dismutase activity. Langmuir, 17, 5621 (2001).[read online]
A. Warshawsky, N. Kahana, V. Kampel, I. Rogachev, E. Meinhardt, R. Kautzmann, J.L. Cortina and C. Sampaio. Ion exchange resins for goldcyanide extraction containing a piperazine funcionality. Part 1: Synthesis and physico-chemical properties. Macromol. Mat. Eng. 283, 103 (2000).[read online]
A. Florido, I. Casas, J. García-Raurich, R. Arad-Yellin, and A. Warshawsky. Uranyl-selective electrode based on a new bifunctional derivative combining the synergistic properties of phosphine oxide and ester of phosphoric acid. Anal. Chem., 72, 1604 (2000).[read online]
E. Escaterina, M..A. Brebu, A. Warshawsky and C. Vasile, Polymers with pendant functional groups. V. Thermooxidative and thermal behavior of chloromethylated polysulfones. Polymer Degradation and Stability 69, 175 (2000).[read online]
I. Rogachev, V. Gusis, A. Gusis, J. L. Cortina, J. Gressel, and A. Warshawsky, Spectrophotomic determination of copper complexation properties of new amphiphilic dithiocarbamates. React. Funct. Polym. 42, 243 (1999).[read online]
State-of-the-art: selective ion-complexing polymers. In: Reactive and Functional Polymers, Alexandratos, S.D., Warshawsky, A., (Eds.) Elsevier, Amsterdam, Netherlands p.99 (1998).
V. Gorshkov, D. Muraviev, A. Warshawsky, Ion-exchange methods for ultra purification of inorganic, organic and biological substances. Solvent Extr. Ion Exch. 16, 1 (1998).[read abstract]
Ion exchange: theory and practice, advances of Russian scientists. In: Solvent Extraction and Ion Exchange, Muraviev, D., Gorshkov, V., Warshawsky, A., (Eds.) Dekker, New York p.457 (1998).
I. Rogachev, V. Kampel, V. Gusis, N. Cohen, J. Gressel, and A. Warshawsky. Synthesis, properties, and use of copper-chelating amphiphilic dithiocarbamates as synergists of oxidant-generating herbicides. Pestic. Biochem. Physiol., 60, 133 (1998).[read online]
J. L. Cortina, R. Arad-Yellin, N. Miralles, A. M. Sastre, A.Warshawsky. Kinetics studies on heavy metal ions extraction by Amberlite XAD2 impregnated resins containing a bifunctional organophosphorous extractant. React. Funct. Polym. 38, 269 (1998).[read online]
C. Vasile, E. Costea, M.C. Pascu, A. Warshawsky. Thermoxidative decomposition of some polysulfones under dynamic conditions of heating. J. Therm. Anal. Calorim. 52, 569 (1998).[read abstract]
J.L.M. Martin, A. Warshawsky, A. Breskin and R. Chechik. Designing low-ionization potential analogs of tetrakis-dimethylamino-ethylene (TMAE) using density functional calculations. Chem. Phys. Lett. 279, 389 (1997).[read online]
A.G. Strikovsky, K. Jerabek, J.L. Cortina and A. Warshawsky. Novel solvent impregnated resins containing di-(2-ethylhexyl)dithio.phosphoric acid on the reactive support. Solvent Extr. Ion Exch. 15, 259 (1997).[read abstract]
J. Ratner, N. Kahana, A. Warshawsky and V. Krongauz. Photochromic polysulfones. 2. Photochromic properties of polymeric polsulfone carrying pendant spiropyran and spirooxazine groups. Ind. Eng. Chem. Res. 35, 1307 (1996).[read online]
D. Muraviev, and A. Warshawsky. Hydrolysis of trimethylamine borane in the presence of liquid and solid (polymeric) acids. React. Funct. Polym. 31, 187 (1996).[read online]
A.G. Strikovsky, K. Jerabek, J.L. Cortina, A.M. Sastre and A. Warshawsky. Solvent impregnated resin (SIR) containing dialkyl dithiophosphoric acid on Amberlite XAD-2: extraction of copper and comparison to the liquid-liquid extraction. React. Funct. Polym. 28, 149 (1995).
K. Jerabek, L. Hankova, A.G. Strikovsky and A. Warshawsky, Solvent impregnated resins: relation between impregnation process and polymer support morphology: I. Di-(2-ethylhexyl)dithio.phosphoric acid. React. Funct. Polym. 28, 201 (1995).
A. Warshawsky, N. Kanaha, E. Beery, G. Kesslericekson, A. Novogrodsky and J. Nordenberg. Cytotoxicity effects of transition-metal chelators of the 5-substituted 2-hydroxy-acetophenones and their oximes. Eur. J. Med. Chem. 30, 553 (1995).[read abstract]
A. Warshawsky, N. Kahana, F. Buchholtz, A. Zelikonok, J. Ratner and V. Krongauz. Photochromic polysulfones. 1. Synthesis of polymeric polysulfone carrying pendant spiropyran and spirooxazine groups. Ind. Eng. Chem. Res. 34, 2825 (1995).
A. Warshawsky, R. Kramer and M. Levy. Metal-polymer microdispersions as pseudohonogeneous catalysts. Ind. Eng. Chem. 34, 2821 (1995).
R.Khamizov, D.N. Muraviev and A. Warshawsky. Recovery of valuable mineral components from seawater by ion exchange and sorption methods. In: Ion Exchange and Solvent Extraction, J.A. Mirinsky and Y. Marcus, eds. Vol. 12, pp.93-148 (1995).
H. Kramer, M. Levy and A. Warshawsky. Hydrogen storage by the bicarbonate/formate reaction. Studies on the activity of Pd catalysts. Int. J. Hydrogen Energy 20, 229 (1995).
D. Muraviev and A. Warshawsky, Aqua-impregnated resins: hydrogen-deutrium exchange on trimethylamine borane in an ion-exchange column. React. Polym., 22, 55 (1994).
D. Muriev, I. Rogachev, L. Bromberg and A. Warshawsky, Deutrium-exchange reaction on trimethylamine-borane with sulfonate cation exchanger in the deuterio form. J. Phys. Chem. 98, 718 (1994).
V. Kampbel and A. Warshawsky, Crown-ether-catalyzed synthesis of amine borane and amine trideuterioborane adducts from NaBH4-NaBD4 in ether. J. Organomet. Chem. 469, 15 (1994).
L. Bromberg, D. Muraviev and A. Warshawsky, Hydrolysis of (trimethylamine)borane with ion exchange resins: effect of ionic surfactants. J. Phys. Chem. 97, 139270 (1994).
N. Kahana, R. Arad-Yellin and A. Warshawsky, A conceptual approach to the synthesis of bifunctional EDTA analogs: EDTA-extended polyamides. J. Org. Chem. 59, 4832 (1994).
J.L. Cortina, A. Warshawsky, N. Miralles, M. Aguilar and A.M. Sastre, Removal of heavy metal ions from liquid effluents by solvent impregnated resins. Hydrometallurgy '94, Chapman and Hall, IMM-SCI, London, 725 (1994).