Events

December 14 Thursday
Insights into transcription initiation from single molecule experiments
Special Guest Seminar
Prof. Shimon WeissDepartment of Chemistry & Biochemistry, University of California, Los Angeles
14:00 - 15:00 , Max and Lillian Candiotty Building
Over the past decade, fluorescence-based single-molecule studies significantly contributed to characterizing the mechanism of RNA polymerase at different steps in transcription, especially in transcription initiation. Transcription by bacterial DNA-dependent RNA polymerase is a multistep process that uses genomic DNA to synthesize complementary RNA molecules. Transcription initiation is a highly regulated step in E. coli, but it has been challenging to study its mechanism because of its stochasticity and complexity. In this talk, we will describe how single molecule approaches have contributed to our understanding of transcription and have uncovered mechanistic details that were not observed in conventional assays because of ensemble averaging.
December 25 Monday
"Organic Semiconductors: from Small Molecules to 2D Polymers"
Prof. Dmitrii PerepichkaMcGill University
11:00 - 12:15 , Gerhard M.J. Schmidt Lecture Hall
December 25 Monday
Cell-free circulating tumour DNA as a non-invasive tool for cancer diagnostics and research
Cancer Research Club
Prof. Nitzan RosenfeldCancer Research UK, Cambridge Institute University of Cambridge, UK
14:00 - 15:00 , Max and Lillian Candiotty Building
Cancer is driven by genomic alterations, and can evolve in response to selective pressures. Sampling of tumour material however is a limiting factor for both diagnostics and research. Blood plasma contains cell-free fragments of circulating tumour DNA (ctDNA) that can be collected non-invasively. With advanced genomic techniques this becomes an effective source of information. “Liquid biopsy” assays are now entering clinical use for non-invasive molecular profiling of advanced cancers to guide targeted therapy. Serially-collection plasma samples can be used to track response to treatment, cancer progression and emergence of known or new resistance mechanisms. Methods that can detect minute amounts of ctDNA are being used to study early-stage cancer and for detection of minimal residual disease after initial definitive treatment.
January 01 Monday
"Chiral Single-Walled Carbon Nanotubes – New Platforms for Spintronics"
Prof. Michael J. TherienDuke University
11:00 - 12:15 , Gerhard M.J. Schmidt Lecture Hall
January 08 Monday
"Probing Spatiotemporal Dynamics in all States of Matter"
Prof. Tobias BrixnerUniversity of Wuerzburg
11:00 - 12:15 , Gerhard M.J. Schmidt Lecture Hall
January 11 Thursday
The molecular mechanisms regulating CLL survival
Cancer Research Club
Prof. Idit ShacharDept. of Immunology, WIS
14:00 - 15:00 , Max and Lillian Candiotty Building
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. The disease is characterized by decreased apoptosis and accumulation of mature B lymphocytes. We have previously shown that CD74 induces a downstream cascade that regulates CLL survival. Recently, we showed that CD74-intracellular domain interacts with the transcription factors RUNX and NF-B and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response and cell migration. One of CD74 target genes is CD84. Our results demonstrate that CD84 mediates the interaction of CLL cells with their microenvironment inducing cell survival. In addition, activation of CD84 elevates PD-L1 expression on CLL cells and their microenvironment which interact with PD-1 expressed on T cells. Our results suggest CD84 blockade as a novel therapeutic strategy to reverse tumor-induced immune suppression.
January 11 Thursday
SHIRAT HAMADA
19:30 - 21:00 , Dolfi and Lola Ebner Auditorium
January 15 Monday
TBA
Special Guest Seminar
Dr. Yuval TabachDepartment of Developmental Biology and Cancer Research, The Institute For Medical Research-Israel-Canada The Hebrew University-Hadassah Medical School Jerusalem.
14:00 - 15:00 , Max and Lillian Candiotty Building
January 18 Thursday
The 3rd meeting of the Israeli Breast Cancer Translational Research Group
08:00 - 08:00 , David Lopatie Conference Centre
January 18 Thursday
The 3rd meeting of the Israeli Breast Cancer Translational Research Group
08:00 - 08:00 , David Lopatie Conference Centre