Research

Functions of long noncoding RNAs

In order to understand lncRNA function, we established in the lab several experimental systems where we can perturb and activate lncRNA expression using RNAi, CRISPR/Cas9 editing, or CRISPR interference:

In these systems, we target several carefully selected and conserved lncRNAs and measure the effects on the organismal, cellular and molecular level.

ESC-derived neuronal cells
ESC-derived neuronal cells