Vascular remodelling in cancer

Angiogenesis in ovarian cancer

• Ovarian Carcinoma: Quantitative Biexponential MR Imaging Relaxometry Reveals the Dynamic Recruitment of Ferritin-expressing Fibroblasts to the Angiogenic Rim of Tumors
  Vandsburger M. H., Radoul M., Addadi Y., Mpofu S., Cohen B., Eilam R. & Neeman M. (2013) Radiology. 268, 3, p. 790-801
• Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma
  Appel E., Rabinkov A., Neeman M., Kohen F. & Mirelman D. (2011) Journal of Drug Targeting. 19, 5, p. 326-335
• Peritoneal Adhesion and Angiogenesis in Ovarian Carcinoma Are Inversely Regulated by Hyaluronan: The Role of Gonadotropins
  Tzuman Y., Sapoznik S., Granot D., Nevo N. & Neeman M. (2010) Neoplasia. 12, 1, p. 51-60 
• Gonadotropin-Regulated Lymphangiogenesis in Ovarian Cancer Is Mediated by LEDGF-Induced Expression of VEGF-C
  Sapoznik S., Cohen B., Tzuman Y., Meir G., Ben-Dor S., Harmelin A. & Neeman M. (2009) Cancer Research. 69, 24, p. 9306-9314
• In vivo Imaging of the systemic recruitment of fibroblasts to the angiogenic rim of ovarian carcinoma tumors
  Granot D., Addadi Y., Kalchenko V., Harmelin A., Kunz-Schughart L. A. & Neeman M. (2007) Cancer Research. 67, 19, p. 9180-9189
• Functional and molecular mapping of uncoupling between vascular permeability and loss of vascular maturation in ovarian carcinoma xenografts: The role of stroma cells in tumor angiogenesis
  Gilad A., Israely T., Dafni H., Meir G., Cohen B. & Neeman M. (2005) International Journal of Cancer. 117, 2, p. 202-211
• Magnetic resonance imaging visualization of hyaluronidase in ovarian carcinoma
  Shiftan L., Israely T., Cohen N., Frydman V., Dafni H., Stern R. & Neeman M. (2005) Cancer Research. 65, 22, p. 10316-10323
• The role of angiogenesis, vascular maturation, regression and stroma infiltration in dormancy and growth of implanted MLS ovarian carcinoma spheroids
  Gilead A., Meir G. & Neeman M. (2004) International Journal of Cancer. 108, 4, p. 524-531
• Gonadotropin stimulation of MLS human epithelial ovarian carcinoma cells augments cell adhesion mediated by CD44 and by alpha v-integrin
  Schiffenbauer Y., Meir G., Maoz M., Even-Ram S., Bar-Shavit R. & Neeman M. (2002) Gynecologic Oncology. 84, 2, p. 296-302
• Loss of ovarian function promotes angiogenesis in human ovarian carcinoma
  Schiffenbauer Y., Abramovitch R., Meir G., Nevo N., Holzinger M., Itin A., Keshet E. & Neeman M. (1997) Proceedings of the National Academy of Sciences of the United States of America. 94, 24, p. 13203-13208
• Cyclocreatine transport and cytotoxicity in rat glioma and human ovarian carcinoma cells: P-31-NMR spectroscopy
  Schiffenbauer Y., Meir G., Cohn M. & Neeman M. (1996) American Journal Of Physiology-Cell Physiology. 270, 1, p. C160-C169

Pancreatic cancer

• Intravital imaging of vascular anomalies and extracellular matrix remodeling in orthotopic pancreatic tumors
  Bochner F., Mohan V., Zinger A., Golani O., Schroeder A., Sagi I. & Neeman M. (2019) International Journal of Cancer.
• Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn2+ Ions
  Martins A. F., Jordan V. C., Bochner F., Chirayil S., Paranawithana N., Zhang S., Lo S., Wen X., Zhao P., Neeman M. & Sherry A. D. (2018) Journal of the American Chemical Society. 140, 50, p. 17456-17464

Lymphangiogenesis

• Whole Organ Blood and Lymphatic Vessels Imaging (WOBLI)
  Oren R., Fellus-Alyagor L., Addadi Y., Bochner F., Gutman H., Blumenreich S., Dafni H., Dekel N., Neeman M. & Lazar S. (2018) Scientific Reports. 8, 1412.
• Visualizing vascular permeability and lymphatic drainage using labeled serum albumin
  Vandoorne K., Addadi Y. & Neeman M. (2010) Angiogenesis. 13, 2, p. 75-85
• Lymphatic vessel density and function in experimental bladder cancer
  Saban M. R., Towner R., Smith N., Abbott A., Neeman M., Davis C. A., Simpson C., Maier J., Memet S., Wu X. & Saban R. (2007) BMC Cancer. 7,
• Transcriptional Regulation of Vascular Endothelial Growth Factor C by Oxidative and Thermal Stress Is Mediated by Lens Epithelium-Derived Growth Factor/p75
  Cohen B., Addadi Y., Sapoznik S., Meir G., Kalchenko V., Harmelin A., Ben-Dor S. & Neeman M. (2009) Neoplasia. 11, 9, p. 921-933
• Gonadotropin-Regulated Lymphangiogenesis in Ovarian Cancer Is Mediated by LEDGF-Induced Expression of VEGF-C
  Sapoznik S., Cohen B., Tzuman Y., Meir G., Ben-Dor S., Harmelin A. & Neeman M. (2009) Cancer Research. 69, 24, p. 9306-9314
• Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype
  Pathak A., Artemov D., Neeman M. & Bhujwalla Z. (2006) Cancer Research. 66, 10, p. 5151-5158
• Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: Magnetic resonance imaging, confocal microscopy, and histological tracking of triple-labeled albumin
  Dafni H., Israely T., Bhujwalla Z., Benjamin L. & Neeman M. (2002) Cancer Research. 62, 22, p. 6731-6739
• MRI and fluorescence microscopy of the acute vascular response to VEGF165: vasodilation, hyper-permeability and lymphatic uptake, followed by rapid inactivation of the growth factor
  Dafni H., Landsman L., Schechter B., Kohen F. & Neeman M. (2002) NMR in Biomedicine. 15, 2, p. 120-131