The Amit lab studies the genomic code enabling immune cells to differentiate to specific subtypes and devise a specific response to invading pathogens. Our main focus is to understand how gene regulatory networks activate this code. We develop and apply state of the art high throughput genomic tools and interdisciplinary approaches to address these critical biological and therapeutic questions. We believe that elucidating the underlying principles of the regulatory code will allow us to impact the future of personalized medicine. We are currently seeking highly motivated individuals who want to join us on this quest.
Our goal is to decipher the regulatory code. Using concepts from various disciplines; functional genomics, molecular biology computer science, physics and biotechnology to conceive novel approaches to undertake this grand challenge . This knowledge will allow us to engineer cells and devise a personalized treatment based on the individual genome sequence.
"Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types"
We introduce an automated massively parallel single-cell RNA sequencing (RNA-seq) approach for analyzing in vivo transcriptional states in thousands of single cells. Combined with unsupervised classification algorithms, this facilitates ab initio cell-type characterization of splenic tissues.
(SCIENCE 2014 Vol 343)
We are currently seeking talented and motivated individuals with various backgrounds, ranging from computer science to molecular biology.