We study how immune cells devise a specific response to invasion by pathogenic bacteria or viruses. Our main focus is on the principles of dynamic gene regulation. We develop and apply state of the art high throughput genomic tools and interdisciplinary approaches to address burning questions in biology and medicine. We believe that understanding the principles of regulation of the transcriptional response and how it is encoded in the genome will allow us to impact the future of personalized medicine. We’re currently seeking highly motivated investigators who want to join us on this quest.
research
We use concepts from various disciplines; functional genomics, molecular biology computer science, physics and biotechnology to conceive novel approaches to undertake this challenge in unbiased fashion. We believe that understanding the principals of the transcriptional response and how it is encoded in the DNA, will allow us to predict the outcome of the response of different individuals and therefore to devise personalized remedy.
publications
Recently published:
"Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses"
(Published online: Sep 3, 2009)
Recently published:
"Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells"
(Published online April 24 2011)
group
We are currently seeking talented and motivated individuals with various backgrounds, ranging from computer science to molecular biology.
contact
Weizmann Institute
Wolfson bldg., Room 252
Rehovot, 76100
Israel
ido.amit@weizmann.ac.il
Broad Institute
7 Cambridge Center
Cambridge, MA 02143
United States
iamit@broadinstitute.org