The Amit lab studies the genomic code enabling immune cells to differentiate to specific subtypes and devise a specific response to invading pathogens. Our main focus is to understand how gene regulatory networks activate this code. We develop and apply state of the art high throughput genomic tools and interdisciplinary approaches to address these critical biological and therapeutic questions. We believe that elucidating the underlying principles of the regulatory code will allow us to impact the future of personalized medicine. We are currently seeking highly motivated individuals who want to join us on this quest.
Our goal is to decipher the regulatory code. Using concepts from various disciplines; functional genomics, molecular biology computer science, physics and biotechnology to conceive novel approaches to undertake this grand challenge . This knowledge will allow us to engineer cells and devise a personalized treatment based on the individual genome sequence.
"The Transcriptional Landscape of Mammalian Cells"
Gene function is specified by millions of interactions between regulatory proteins with DNA elements. In this paper we mapped these circuits utilizing our new method, HT-ChIP, and find that the epigenetic and transcriptional state is established by a hierarchical division of labor among transcriptional regulators.
(Molecular Cell, August 2012; Nature Protocols 2013)
We are currently seeking talented and motivated individuals with various backgrounds, ranging from computer science to molecular biology.