Benny Geiger's Lab

The intraocular pressure that affects the retina in glaucoma patients can be lowered by variety of cytoskeleton targeted treatments We use electron microscopy to monitor the structural changes induced by drugs such as H-7 and latrunculin as well as cytoskeletal-active proteins, including caldesmon and C3 toxin (introduced by infection with adenoviral vectors, containing the respective genes).

Electron micrograph

of the inner wall of Schema's canal (SC) following vehicle (a,c) or LAT-B (b,d,e,f,g) AJ, adherens junctions; ECM,Exstracellular matrix;JXT,juxtacanalicular region; MF,microfilaments;MT,microtubules;MVB, multivesicular bodies; TJ,tight junctions. Bar=100nm