The main goal of our group is to explore the molecular circuitries and biological processes that suppress the emergence of cancer, and the mechanisms that cause deregulation of those processes in tumors. A key player in many of those processes is the p53 tumor suppressor. In approximately 50% of human cancers, p53 is mutated. In many of the remaining cases, the function of the non-mutated p53 protein is compromised.
We wish to elucidate the biochemical and biological basis for the ability of p53 to act as a tumor suppressor, and the consequences of its deregulation in cancer.