The main goal of our group is to explore the molecular circuitries and biological processes that suppress the emergence of cancer, and the mechanisms that cause deregulation of those processes in tumors. A key player in many of those processes is the p53 tumor suppressor. In approximately 50% of human cancers, p53 is mutated. In many of the remaining cases, the function of the non-mutated p53 protein is compromised.
Research in the Oren lab is supported by the Dr. Miriam and Sheldon G Adelson Medical Research Foundation, a Center of Excellence from the Israel Science Foundation, the MINERVA Stiftung with funds from the BMBF of the Federal Republic of Germany, a grant from the Canadian Institutes of Health Research (CIHR), the International Development Research Centre (IDRC), the Israel Science Foundation (ISF) and the Azrieli Foundation, a grant from the Ministry of Science & Technology of the State of Israel and the German Cancer Research Center (DKFZ), The Thompson Family Foundation, The Rising Tide Foundation, The Comisaroff Family Trust, The Joel and Mady Dukler Fund for Cancer Research, and the Moross Integrated Cancer Center.
We wish to elucidate the biochemical and biological basis for the ability of p53 to act as a tumor suppressor, and the consequences of its deregulation in cancer.