Our research interests are in Melanoma Functional Genomics and Melanoma Immuno-Genomics.
Our group aims to discover recurrent tumor-specific mutations in melanoma using high-throughput, whole exome and whole genome sequencing approaches. Once mutations are identified, our group focuses on characterizing the biochemical, functional, and clinical aspects of the most highly mutated genes.
To facilitate this search, in collaboration with the National Cancer Institute, we have established a bank of metastatic melanoma tumors and matched normal tissues. In addition to the potential insights into basic tumor biology new opportunities for clinical intervention are likely to be generated through this research.