Publications

Selected recent publications (see pubmed for full list)

*- Equal first-authors; # - Corresponding author

2018

  • Keskin DB*, Anandappa AJ*, Sun J*, Tirosh I*, et al. (2019). “Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial”. Nature 565(7738):234-239. [PDF]

  • Tirosh I#, Suva ML (2018). “Deciphering Human Tumor Biology by Single-Cell Expression Profiling”. Annual Reviews Cancer Biology Vol. 3. [PDF]

  • Filbin MG*, Tirosh I*, Hovestadt* et al. (2018). “Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq”. Science 360(6386): 331-335. [PDF]

2017

  • Puram S*, Tirosh I*# et al. (2017). “Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer”. Cell 171(7):1611-1624. [PDF]     
  • Venteicher A*, Tirosh I*#, Hebert C, Yizhak K, Neftel C, Filbin MG, Escalante L, Shaw M, Rodman C, Nahed B, Cahill D, Curry W, Martuza R, Mylvaganam R, Iafrate J, Frosch M, Golub T, Rivera M, Patel A, Rozenblatt-Rosen O, Getz G, Bernstein B, Louis D, Regev A, Suvà M (2017). “Decoupling genetic, developmental and micro-environmental programs in IDH-mutant gliomas through single-cell transcriptomics”. Science 355(6332). [PDF]

2016

  • Tirosh I*, Venteicher A*, Hebert C, Escalante L, Patel A, Yizhak K, Fisher J, Desai N, Rodman C, Luo C, Francis J, Mount C, Onozato M, Riggi N, Livak K, Filbin M, Gennert D, Satija R, Nahed B, Cahill D, Curry W, Martuza R, Mylvaganam R, Iafrate J, Frosch M, Golub T, Rivera M, Rozenblatt-Rosen O, Getz G, Monje M, Bernstein B, Louis D, Regev A, Suvà M (2016). "Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma." Nature 539(7628):309-313. [PDF]
  • Tirosh I*, Izar B*, Prakadan S, Wadsworth M, Treacy D, Trombetta J, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin J, Cohen O, Shah P, Lu D, Genshaft A, Hughes T, Ziegler C, Kazer S, Gaillard A, Kolb K, Villani A, Johannessen C, Andreev A, Van Allen E, Bertagnolli M, Sorger P, Sullivan R, Flaherty K, Frederick D, Jané-Valbuena J, Yoon C,  Rozenblatt-Rosen O, Shalek A, Regev A and Garraway L (2016). "Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq." Science 352(6282): 189-196. [PDF]

2015

  • Kowalczyk MS*., Tirosh I*, D. Heckl, T. N. Rao, A. Dixit, B. J. Haas, R. K. Schneider, A. J. Wagers, B. L. Ebert and A. Regev (2015). "Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells." Genome Res 25(12): 1860-1872. [PDF]

2014

  • Patel AP*., Tirosh I*, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suva ML, Regev A and Bernstein BE (2014). "Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma." Science 344(6190): 1396-1401. [PDF]