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Our lab studies cellular communication pathways that regulate differentiation and decision-making processes in cells, from a systems level perspective. We focus on the way extracellular information is perceived by individual cells and control their response. Using single cell quantitative tools, we study the encoding of the extracellular signals into few intracelluar mediators, and map the spectrum of responses generated by a large space of combinatorial cues. Combining experimental approaches with mathematical modeling, we generate predictive bio-physical models, providing a deeper understanding of these cellular processes.