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Polyamines: Regulation and Molecular Functions

Publications

  • Landau G, Ran A, Bercovich Z, Feldmesser E, Horn-Saban S, Korkotian E, Jacob-Hirsh J, Rechavi G, Ron D, Kahana C,. 2012 Expression Profiling and Biochemical Analysis Suggest Stress Response as a Potential Mechanism Inhibiting Proliferation of Polyamine-Depleted Cells. Journal of Biological Chemistry, 287: 35825-35837
  • Bercovich Z, Snapir Z, Keren-Paz A, Kahana C,. 2011 Antizyme Affects Cell Proliferation and Viability Solely Through Regulating Cellular Polyamines. Journal of Biological Chemistry, 286: 33778-33783
  • Adler J, Reuven N, Kahana C, Shaul Y,. 2010 C-Fos Proteasomal Degradation is Activated by a Default Mechanism, and Its Regulation by Nad(p)h:Quinone Oxidoreductase 1 Determines c-Fos Serum Response Kinetics. Molecular and Cellular Biology, 30: 3767-3778
  • Landau G, Bercovich Z, Park MH, Kahana C,. 2010 The Role of Polyamines in Supporting Growth of Mammalian Cells is Mediated Through Their Requirement For Translation Initiation and Elongation. Journal of Biological Chemistry, 285: 12474-12481
  • Kahana C,. 2009 Regulation of Cellular Polyamine Levels and Cellular Proliferation by Antizyme and Antizyme Inhibitor. Essays in Biochemistry, Vol 46, 46: 47-61
  • Landau G, Kahana C,. 2009 Determination of Global Effect of Polyamines on Regulating Growth Related Gene Expression. Amino Acids, 37: 50
  • Kahana C,. 2009 Antizyme and Antizyme Inhibitor, a Regulatory Tango. Cellular and Molecular Life Sciences, 66: 2479-2488
  • Snapir Z, Keren-Paz A, Bercovich Z, Kahana C,. 2009 Antizyme 3 Inhibits Polyamine Uptake and Ornithine Decarboxylase (Odc) Activity, But Does Not Stimulate Odc Degradation. Biochemical Journal, 419: 99-103
  • Albeck S, Dym O, Unger T, Snapir Z, Bercovich Z, Kahana C,. 2008 Crystallographic and Biochemical Studies Revealing the Structural Basis For Antizyme Inhibitor Function. Protein Science, 17: 793-802
  • Snapir Z, Keren-Paz A, Bercovich Z, Kahana C,. 2008 Odcp, a Brain- and Testis-Specific Ornithine Decarboxylase Paralogue, Functions as an Antizyme Inhibitor, Although Less Efficiently Than Azi1. Biochemical Journal, 410: 613-619
  • Porat Z, Landau G, Bercovich Z, Krutauz D, Glickman M, Kahana C,. 2008 Yeast Antizyme Mediates Degradation of Yeast Ornithine Decarboxylase by Yeast But Not by Mammalian Proteasome - New Insights on Yeast Antizyme. Journal of Biological Chemistry, 283: 4528-4534
  • Kahana C,. 2007 Ubiquitin Dependent and Independent Protein Degradation in the Regulation of Cellular Polyamines. Amino Acids, 33: 225-230
  • Keren-Paz A, Bercovich Z, Kahana C,. 2007 Antizyme Inhibitor: a Defective Ornithine Decarboxylase or a Physiological Regulator of Polyamine Biosynthesis and Cellular Proliferation. Biochemical Society Transactions, 35: 311-313
  • Keren-Paz A, Bercovich Z, Porat Z, Erez O, Brener O, Kahana C. 2006 Overexpression of Antizyme-Inhibitor in Nih3t3 Fibroblasts Provides Growth Advantage Through Neutralization of Antizyme Functions. Oncogene, 25: 5163-5172
  • Kahana C, Asher G, Shaul Y. 2005 Mechanisms of Protein Degradation - an Odyssey With Odc. Cell Cycle, 4: 1461-1464
  • Asher G, Tsvetkov P, Kahana C, Shaul Y. 2005 A Mechanism of Ubiquitin-Independent Proteasomal Degradation of the Tumor Suppressors p53 and p73. Genes & Development, 19: 316-321
  • Bercovich Z, Kahana C. 2004 Degradation of Antizyme Inhibitor, an Ornithine Decarboxylase Homologous Protein, is Ubiquitin-Dependent and is Inhibited by Antizyme. Journal of Biological Chemistry, 279: 54097-54102
  • Gandre S, Bercovich Z, Kahana C. 2003 Mitochondrial Localization of Antizyme is Determined by Context-Dependent Alternative Utilization of Two Aug Initiation Codons. Mitochondrion, 2: 245-256
  • Gandre Shilpa, Bercovich Zippi, Kahana Chaim. 2002 Ornithine Decarboxylase-Antizyme is Rapidly Degraded Through a Mechanism That Requires Functional Ubiquitin-Dependent Proteolytic Activity.. European Journal of Biochemistry / Febs, 269: 1316-22
  • Gandre Shilpa, Kahana Chaim. 2002 Degradation of Ornithine Decarboxylase in Saccharomyces Cerevisiae is Ubiquitin Independent.. Biochemical and Biophysical Research Communications, 293: 139-44
  • Erez Omri, Kahana Chaim. 2002 Deletions of Sky1 or Ptk2 in the Saccharomyces Cerevisiae Trk1deltatrk2delta Mutant Cells Exert Dual Effect on Ion Homeostasis.. Biochemical and Biophysical Research Communications, 295: 1142-9
  • Asher Gad, Lotem Joseph, Sachs Leo, Kahana Chaim, Shaul Yosef, ET AL. 2002 Mdm-2 and Ubiquitin-Independent p53 Proteasomal Degradation Regulated by Nqo1.. Proceedings of the National Academy of Sciences of the United States of America, 99: 13125-30
  • Erez Omri, Goldstaub Dan, Friedman Joseph, Kahana Chaim, ET AL. 2002 Putrescine Activates Oxidative Stress Dependent Apoptotic Death in Ornithine Decarboxylase Overproducing Mouse Myeloma Cells.. Experimental Cell Research, 281: 148-56
  • Erez O, Kahana C. 2001 Screening For Modulators of Spermine Tolerance Identifies Sky1, the sr Protein Kinase of Saccharomyces Cerevisiae, as a Regulator of Polyamine Transport and Ion Homeostasis. Molecular and Cellular Biology, 21: 175-184
  • Ciechanover A, Gonen H, Bercovich B, Cohen S, Fajerman I, Israel A, Mercurio F, Kahana C, Schwartz AL, Iwai K, Orian A. 2001 Mechanisms of Ubiquitin-Mediated, Limited Processing of the nf-Kappa b1 Precursor Protein p105. Biochimie, 83: 341-349
  • Goldstaub D, Gradi A, Bercovitch Z, Grosmann Z, Nophar Y, Luria S, Sonenberg N, Kahana C. 2000 Poliovirus 2a Protease Induces Apoptotic Cell Death. Molecular and Cellular Biology, 20: 1271-1277
  • Orian A, Schwartz AL, Israel A, Whiteside S, Kahana C, Ciechanover A. 1999 Structural Motifs Involved in Ubiquitin-Mediated Processing of the nf-Kappa b Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain. Molecular and Cellular Biology, 19: 3664-3673
  • Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B,. 1998 Insulin Induces Transcription of Target Genes Through the Hypoxia-Inducible Factor Hif-1 Alpha/Arnt. EMBO Journal, 17: 5085-5094
  • Gross-Mesilaty S, Reinstein E, Bercovich B, Tobias KE, Schwartz AL, Kahana C, Ciechanover A,. 1998 Basal and Human Papillomavirus e6 Oncoprotein-Induced Degradation of Myc Proteins by the Ubiquitin Pathway. Proceedings of the National Academy of Sciences of the United States of America, 95: 8058-8063
  • Tobias KE, Kahana C,. 1995 Exposure to Ornithine Results in Excessive Accumulation of Putrescine and Apoptotic Cell-Death in Ornithine Decarboxylase Overproducing Mouse Myeloma Cells. Cell Growth & Differentiation, 6: 1279-1285
  • Tobias KE, Shor J, Kahana C,. 1995 C-Myc and Max Transregulate the Mouse Ornithine Decarboxylase Promoter Through Interaction With 2 Downstream Cacgtg Motifs. Oncogene, 11: 1721-1727
  • Elias S, Bercovich B, Kahana C, Coffino P, Fischer M, Hilt W, Wolf DH, Ciechanover A,. 1995 Degradation of Ornithine Decarboxylase by the Mammalian and Yeast 26s Proteasome Complexes Requires All the Components of the Protease. European Journal of Biochemistry, 229: 276-283
  • Rom E, Kahana C,. 1994 Polyamines Regulate the Expression of Ornithine Decarboxylase Antizyme in-Vitro by Inducing Ribosomal Frame-Shifting. Proceedings of the National Academy of Sciences of the United States of America, 91: 3959-3963
  • Mamroudkidron E, Rosenberghasson Y, Rom E, Kahana C,. 1994 The 20s Proteasome Mediates the Degradation of Mouse and Yeast Ornithine Decarboxylase in Yeast-Cells. Febs Letters, 337: 239-242
  • Gonen H, Smith CE, Siegel NR, Kahana C, Merrick WC, Chakraburtty K, Schwartz AL, Ciechanover A,. 1994 Protein-Synthesis Elongation-Factor ef-1-Alpha is Essential For Ubiquitin-Dependent Degradation of Certain n-Alpha-Acetylated Proteins and May be Substituted For by the Bacterial Elongation-Factor ef-tu. Proceedings of the National Academy of Sciences of the United States of America, 91: 7648-7652
  • Mamroudkidron E, Kahana C,. 1994 The 26s Proteasome Degrades Mouse and Yeast Ornithine Decarboxylase in Yeast-Cells. Febs Letters, 356: 162-164
  • Mamroudkidron E, Omeritsicovich M, Bercovich Z, Tobias KE, Rom E, Kahana C,. 1994 A Unified Pathway For the Degradation of Ornithine Decarboxylase in Reticulocyte Lysate Requires Interaction With the Polyamine-Induced Protein, Ornithine Decarboxylase Antizyme. European Journal of Biochemistry, 226: 547-554
  • Tobias KE, Kahana C,. 1993 Intersubunit Location of the Active-Site of Mammalian Ornithine Decarboxylase as Determined by Hybridization of Site-Directed Mutants. Biochemistry, 32: 5842-5847
  • Tobias KE, Mamroudkidron E, Kahana C,. 1993 Gly387 of Murine Ornithine Decarboxylase is Essential For the Formation of Stable Homodimers. European Journal of Biochemistry, 218: 245-250
  • Rom E, Kahana C,. 1993 Isolation and Characterization of the Drosophila Ornithine Decarboxylase Locus - Evidence For the Presence of 2 Transcribed Odc Genes in the Drosophila Genome. DNA and Cell Biology, 12: 499-508
  • Bercovich Z, Kahana C,. 1993 Involvement of the 20s-Proteasome in the Degradation of Ornithine Decarboxylase. European Journal of Biochemistry, 213: 205-210
  • Rosenberghasson Y, Bercovich Z, Kahana C,. 1991 Characterization of Sequences Involved in Mediating Degradation of Ornithine Decarboxylase in Cells and in Reticulocyte Lysate. European Journal of Biochemistry, 196: 647-651
  • Rosenberghasson Y, Strumpf D, Kahana C,. 1991 Mouse Ornithine Decarboxylase is Phosphorylated by Casein Kinase-II at a Predominant Single Location (Serine-303). European Journal of Biochemistry, 197: 419-424
  • Rosenberghasson Y, Bercovich Z, Kahana C,. 1991 Cis-Recognition and Degradation of Ornithine Decarboxylase Subunits in Reticulocyte Lysate. Biochemical Journal, 277: 683-685
  • Rosenberghasson Y, Bercovich Z, Ciechanover A, Kahana C,. 1989 Degradation of Ornithine Decarboxylase in Mammalian-Cells is Atp Dependent But Ubiquitin Independent. European Journal of Biochemistry, 185: 469-474
  • Katz A, Kahana C,. 1989 Rearrangement Between Ornithine Decarboxylase and the Switch Region of the Gamma-1 Immunoglobulin Gene in Alpha-Difluoromethylornithine Resistant Mouse Myeloma Cells. EMBO Journal, 8: 1163-1167
  • Bercovich Z, Rosenberghasson Y, Ciechanover A, Kahana C,. 1989 Degradation of Ornithine Decarboxylase in Reticulocyte Lysate is Atp-Dependent But Ubiquitin-Independent. Journal of Biological Chemistry, 264: 15949-15952
  • Katz A, Kahana C,. 1988 Isolation and Characterization of the Mouse Ornithine Decarboxylase Gene. Journal of Biological Chemistry, 263: 7604-7609
  • Assaraf YG, Kahana C, Spira DT, Bachrach U,. 1988 Plasmodium-Falciparum - Purification, Properties, and Immunochemical Study of Ornithine Decarboxylase, the Key Enzyme in Polyamine Biosynthesis. Experimental Parasitology, 67: 20-30
  • Katz A, Kahana C,. 1987 Transcriptional Activation of Mammalian Ornithine Decarboxylase During Stimulated Growth. Molecular and Cellular Biology, 7: 2641-2643
  • Maroteaux L, Kahana C, Mory Y, Groner Y, Revel M,. 1983 Sequences Involved in the Regulated Expression of the Human Interferon-Beta-1 Gene in Recombinant SV40 DNA Vectors Replicating in Monkey Cells. EMBO Journal, 2: 325-332
  • Kahana C, Gidoni D, Canaani D, Groner Y,. 1981 Simian Virus-40 Early Messenger-Rnas in Lytically Infected and Transformed-Cells Contain 6 5'-Terminal Caps. Journal of Virology, 37: 7-16
  • Kahana C, Yakobson E, Revel M, Groner Y,. 1981 Increased Methylation of RNA in SV40-Infected Interferon-Treated Cells. Virology, 112: 109-118
  • Gidoni D, Kahana C, Canaani D, Groner Y,. 1981 Specific Invitro Initiation of Transcription of Simian Virus-40 Early and Late Genes Occurs at the Various Cap Nucleotides Including Cytidine. Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences, 78: 2174-2178
  • Finkel D, Kahana C, Groner Y,. 1981 Sequence Determination of the Major N6-Methyl Adenosine-Containing Oligonucleotides of SV40 Messenger-RNA. Israel Journal of Medical Sciences, 17: 476
  • Kahana C, Groner Y,. 1980 Transcription of Simian Virus-40 Starts at Multiple Sites of the Viral Genome. Israel Journal of Medical Sciences, 16: 486
  • Canaani D, Kahana C, Lavi S, Groner Y,. 1979 Identification and Mapping of N6-Methyladenosine Containing Sequences in Simian Virus-40 RNA. Nucleic Acids Research, 6: 2879-2899
  • Canaani D, Kahana C, Mukamel A, Groner Y,. 1979 Sequence Heterogeneity at the 5' Termini of Late Simian Virus-40-19s and 16s Messenger-Rnas. Proceedings of the National Academy of Sciences of the United States of America, 76: 3078-3082
  • Canaani D, Kahana C, Mukamel A, Groner Y,. 1979 Sequence Heterogeneity and Multiple Caps at the 5'-Termini of Simian-Virus 40 Early and Late Messenger-RNA. Israel Journal of Medical Sciences, 15: 792-793