Forming the Cortex-Translating Environmental Cues to Cellular Responses

 

The main interest of our lab is the process of embryonic brain development and what goes awry during disease conditions. In the developing brain there is a relative change in the type of neuronal stem cells that are born and in addition neurons are born in one position and have to migrate to their final destination by active cell migration. These are very dynamic processes that are regulated via the concerted action of multiple gene products. In humans this process occurs over the period of several months.

Aberrant neuronal stem cell proliferation and migration may result in devastating consequences, such as severe brain malformation, mental retardation, epileptic seizures and early death. A significant portion of our studies are focused on one severe form of brain malformation, known as lissencephaly, which means "smooth brain". Over the years we have found that genes associated with this disease and other genes affect a variety of polarity decisions. Our studies are conducted using interdisciplinary approaches combining molecular, biochemical, in vivo, ex vivo, and in vitro studies with mouse and human brain organoid models. Overall our studies have implications for a wide range of human developmental diseases ranging between brain malformations such as microcephaly and lissencephaly and diseases such as epilepsy, autism spectrum disorders, intellectual disabilities and schizophrenia.

 

Links to sites describing highlights of our research in English:

wis-wander.weizmann.ac.il/life-sciences/“brain-chip”-reveals-how-brain-folds

idw-online.de/en/news300021

www.innovations-report.com/html/reports/life_sciences/extra_copies_a_gene_carry_extra_risk_126807.html

http://www.weizmann.ac.il/pages/journey-developing-brain

http://wis-wander.weizmann.ac.il/life-sciences/double-duty-immune-proteins-discovered-aiding-brain-development

Links to sites describing highlights of our research in Hebrew:

www.ynet.co.il/articles/0,7340,L-5121284,00.html#autoplay

heb.wis-wander.weizmann.ac.il/לגדל-מוחות-מיניאטוריים-במעבדה-–-ולגלות-כיצד-נוצרים-הקפלים-במוח-האדם/מדעי-החייםחדשות-מדע-בשפה

www.kan-naim.co.il/artical.asp

www.ynet.co.il/articles/0,7340,L-3605923,00.html

stwww.weizmann.ac.il/G-JUNIOR/weizmann-paper/52/3.html

http://www.weizmann.ac.il/pages/he/journey-developing-brain

http://heb.wis-wander.weizmann.ac.il/%D7%A1%D7%95%D7%9B%D7%A0%D7%99%D7%9D-%D7%9B%D7%A4%D7%95%D7%9C%D7%99%D7%9D-%D7%97%D7%9C%D7%91%D7%95%D7%A0%D7%99-%D7%94%D7%9E%D7%A2%D7%A8%D7%9B%D7%AA-%D7%94%D7%97%D7%99%D7%A1%D7%95%D7%A0%D7%99%D7%AA-%D7%9E%D7%A1%D7%99%D7%99%D7%A2%D7%99%D7%9D-%D7%9C%D7%94%D7%AA%D7%A4%D7%AA%D7%97%D7%95%D7%AA-%D7%94%D7%9E%D7%95%D7%97/%D7%9E%D7%93%D7%A2%D7%99-%D7%94%D7%97%D7%99%D7%99%D7%9D

 

Updated: 22/03/2018 09:35:24    Contact E-mail: Orly.Reiner@weizmann.ac.il