The role of DNA damage in differentiation
we have identified a new signaling pathway that is activated in response to DNA damage. the major players of this signaling pathway are the tyrosine kinase c-Abl (a proto-oncogene), p73 (a member of p53 tumor suppressor proteins), and Yap (the downstream effector of Hippo pathway that regulates organ size). we have preliminary data to show that this pathway is involved in differentiation of muscle and Fat cells.