Our microbial genomics lab focuses on two main research directions:
Prof. Rotem Sorek
Incumbent of the Rowland and Sylvia Schaefer Career Development Chair
Office: Meyer Building, Room 210A
Department of Molecular Genetics
Weizmann Institute of Science
Rehovot 76100, Israel
The interactions between bacteria and the viruses that infect them (phages). We study how phages attack bacteria, and how bacteria defend themselves against such attacks. We are intersted in deciphering the molecular mechanisms providing bacteria with protection against phages, collectively known as the "immune system" of bacteria. Specifically, we study the CRISPR-Cas system, which is the adaptive immunity system of microbes, as well as new anti-phage defense systems discovered in our lab. We also study the arbitrium system, a small-molecule communication system that we have discovered, allowing phages to coordinate their infection dynamics.
RNA-mediated regulation in microbes. We study the complex transcriptomes of bacteria, and how non-coding RNAs regulate key processes in the prokaryotic cell. We are also developing new technologies for accurate measurements of RNA in microbes, leading to multi-layered, single-base resolution expression maps of microbes and microbiomes.
Our research combines computational genomics techniques, systems biology, metagenomics, high-throughput sequencing technologies, and modern experimental approaches in microbiology and phage biology.
Current research directions in the lab include:
- CRISPR, an antiviral microbial defense system
- New defense systems and the arms-race between bacteria and phage
- Small molecule communication between phages
- RNA-mediated regulation in microbes
- Microbial genome evolution
- Computational discovery of novel natural antibiotics
- Whole genome and transcriptome sequencing with the Illumina technology