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One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
Localization:
Intensity:
Fold change:
Significance:
  • C’ GFP library in SD
    YML075C
    nuclear periphery
    47.2
  • N' NOP1pr-GFP in SD
    YML075C
    ER,nuclear periphery
    69.4183
  • N' TEF2pr-mCherry in SD
    YML075C
    ER,nuclear periphery
    134.491
  • N' NATIVEpr-GFP in SD
    YML075C
    punctate,nuclear periphery
    47.6704
  • N' TEF2pr-VC and Cyto-VN in SD
    YML075C
    ER,punctate
    39.0161
  • C’ GFP library in SD+DTT 
    YML075C
    nuclear periphery
    44.12
    0.93
    No
  • C’ GFP library in SD+H2O2
    YML075C
    nuclear periphery
    57.68
    1.22
    No
  • C’ GFP library in Starvation Media
    YML075C
    nuclear periphery
    43.39
    0.91
    No
  • C’ GFP library on the background of Pup2-DaMP
    noimage.png
    nuclear periphery
  • C’ GFP library on the background of CCT mutant
    noimage.png
    nuclear periphery
    41.147
    0.871539
    No