The Laboratory of Michal Schwartz

Prof. Michal Schwartz The Maurice and Ilse Katz Professorial Chair in Neuroimmunology Tel. (W): +972-8-934-2467 Tel. (H): +972-8-934-3510 Fax: +972-8-934-6018, 934-4131 E-mail: Michal.Schwartz@weizmann.ac.il

Selected Publications

• Rapalino, O., Lazarov-Spiegler, O., Agranov, E., Velan, G., Yoles, E., Solomon, A., Gepstein, R., Katz, A., Belkin, M., Hadani, M. and Schwartz, M. (1998) Implantation of stimulated macrophages leads to partial recovery of paraplegic rats. Nat. Med. 4:814-821.
• Moalem, G., Leibowitz-Amit, R., Yoles, E., Cohen, I.R. and Schwartz, M. (1999) Autoimmune T cells limit secondary degeneration following central nervous system trauma. Nat. Med. 5:49-65. "News and Views", Novak K. Autoimmune T cells - not always bad guys. Nat. Med. 5:28.
• Hauben, E., Butovsky, O., Nevo, U., Yoles, E., Moalem, G., Agranov, E., Leibowitz-Amit, R., Mor, F., Pevsner, E., Akselrod, S., Neeman, M., Cohen, I.R. and Schwartz, M. (2000) Benign Autoimmunity: Neuroprotection by Autoimmune T cells in a Rat Model of Spinal Cord Contusion. J. Neurosci. 20:6421-6430.
• Hauben, E., Agranov, E., Gothilf, A., Nevo, U., Cohen, A., Smirnov, I., Schwartz, M. (2001) Post-traumatic immunization for spinal cord recovery: benefit without risk of pathogenicity. J. Clin. Invest. 108: 591-599.
• Yoles, E., Hauben, E., Palgi, O., Eugenia, A., Kuchroo, V., Cohen, I.R., Weiner, H. and Schwartz, M. (2001) Beneficial autoimmunity is a physiological response to central nervous system trauma. J. Neurosci. 21:3740-3748.
• Hauben, E., Gothilf, A., Cohen, A., Butovsky, O., Nevo, U., Smirnov, I., Yoles, E., Akselrod, S., and Schwartz, M. (2003) Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury. J. Neurosci. 23: 8808-8819.
• Kipnis, J., Cardon, M., Avidan, H., Lewitus, G.M., Mordechay, S., Rolls, A., Shani, Y., and Schwartz, M. (2004) Dopamine, through the ERK pathway, down-regulates CD4+CD25+ regulatory T cell activity: Implications for neurodegeneration. J. Neurosci. 24:6133-6143.
• Ziv,Y., Ron,N. Butovsky, O. Landa, G. Sudai, E., Greenberg, N., Cohen, H., Kipnis, J. and Schwartz, M (2006) Immune Cells Contribute to the Maintenance of Neurogenesis and Spatial learning abilities in Adulthood. Nat. Neurosci. 9 :268-275.
• Butovsky, O., Landa, G., Kunis, G., Ziv, Y., Avidan, H., Greenberg, N., Schwartz, A., Smirnov, I., Pollack, A., Jung, S., and Schwartz, M. (2006). Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J. Clin. Invest. 116, 905-915.
• Ziv, Y., Avidan, H., Pluchino, S., Martino, G., and Schwartz, M. (2006). Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proc. Natl. Acad. Sci. U. S. A. 103:13174-13179.
• Butovsky, O., Koronyo-Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., and Schwartz, M. (2006). From the Cover: Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl. Acad. Sci. U. S. A. 103:11784-11789.
• Rolls, A., Shechter, R. London, A., Ziv, Y., Ronen, A., Levy, R., and Schwartz, M. (2007) Toll-like receptors modulate adult hippocampal neurogenesis. Nat. Cell Biol. 9:1081-1088. "News and Views", Martino G. and Pluchino S. Neural stem cells: guardians of the brain. Nat. Cell Biol. 9:1031-1034.
• Rolls, A., Shechter, R., London, A., Segev, Y., Jacob-Hirsch, J., Amariglio, N., Rechavi, G., and Schwartz, M. (2008). A dual role for chondroitin sulfate proteoglycan in spinal cord repair. PLoS Medicine, 5:1262-1277.
• Rolls, A., R. Shechter, and M. Schwartz. (2009). The bright side of the glial scar in CNS repair. Nat Rev Neurosci., 10:235-241.
• Shechter, R. L., A., Varol, C., Raposo, C., Cusimano, M., Yovel, G., Rolls, A., Mack, M., Pluchino, S., Martino, G., Jung, S. and Schwartz, M. (2009). Infiltrating Blood-Derived Macrophages are Vita Immunoregulatory Cells in Recovery from Spinal Cord Injury. PLoS Med. 6(7):e1000113.
• Cardon, M., Ron-Harel, N,. Cohen, H., Lewitus, G. M., and Schwartz, M. (2009). Dysregulation of kisspeptin and neurogenesis at adolescence link inborn immune deficits to the late onset of abnormal sensorimotor gating in congenital psychological disorders. Mol Psychiatry Jul 28. [Epub ahead of print]