• Picture of Prof. Idit Shachar

    Prof. Idit Shachar

    Analyze the pathway regulateing the survival cascades in Chronic lymphocytic leukemia
    Collaboration with:  Dr Michal Haran, Kaplan Medical center
    Follow the mechanisms controlling homing of immune cells in health and disease.
    Determine the mechanisms regulating peripheral B cell maturation and survival in health and disease.

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  • Picture of Prof. Michael Sela

    Prof. Michael Sela

    An aptamer strategy to target oncogenic signaling in ErbB2 carrying human tumors.
    Collaboration with:  G. Mahlknecht , Y. Yarden G. Mahlknecht
    Synergy of antibodies towards decreasing pancreatic cancer.
    Collaboration with:  R. Maron, B. Schechter, Y. Yarden
    Towards vaccination: Generation of peptide mimotopes specific for anti ErbB-2 monoclonal antibodies.
    Collaboration with:  E. Witsch, Y. Yarden
    Mechanism of action of Copolymer 1 (Copaxone), a therapeutic vaccine against multiple sclerosis.
    Collaboration with:  R. Arnon
    Effective synergism by anti ErbB-2 mAb combinations comprising one mAb against the dimerization site of ErbB-2.
    Collaboration with:  Y. Yarden
    Monoclonal antibodies (mAbs) to ErbB-1 and ErbB-2 receptors and their role in potential anti-tumor strategy.
    Collaboration with:  B. Schechter, Y. Yarden
    Synergistic effects of combinations of mAb against distinct epitopes on EGFR/ErbB-1 and ErbB-2 receptors: accelerated receptor aggregation, down regulation and inhibition of tumor growth.
    Collaboration with:  B. Schechter, Y. Yarden
  • Picture of Prof. Sima Lev

    Prof. Sima Lev

    Breast cancer progression and metastasis.
    Signal transduction therapy for triple negative breast cancer (TNBC).
    PYK2 and FAK as potential therapeutic targets for breast cancer metastasis.
    Chemotherapy resistance and recurrence of breast cancer.

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  • Picture of Dr. Valery Krizhanovsky

    Dr. Valery Krizhanovsky

    The role of cellular senescence in human disease
    Mechanisms of interaction of senescent cells with their microenvironment
    Cellular senescence in cancer development and treatment

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  • Picture of Prof. Atan Gross

    Prof. Atan Gross

    Establishing the role of MTCH2/MIMP in mitochondrial metabolism and apoptosis
    Establishing the role of the ATM-BID pathway in regulating the quiescence of haematopoietic stem cells

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  • Picture of Prof. Lea Eisenbach

    Prof. Lea Eisenbach

    Autoimmunity and immunotherapy
    Collaboration with:  Dr Ilan Volovitz, Prof. Irun Cohen
    Cancer Stem Cells and immunotherapy
    the role of small interferon induced genes in tumorigenicity and apoptosis
    cryoimmunotherapy
    tumor escape and tolerance
    T cell receptor evolution for immunotherapy
    Antigen presentation by engineered MHC molecules
    Collaboration with:  Dr Gideon Gross

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  • Picture of Prof. Eytan Domany

    Prof. Eytan Domany

    Computational Physics: equilibrium and non-equilibrium statistical mechanics of spin glasses
    Collaboration with:  A. P. Young (UCSC)
    Development of tools and algorithms for large scale data analysis. Bioinformatics.
    Analysis of high-throughput biological data (in particular, gene expression data)
    Collaboration with:  Several research groups at Weizmann, in the USA and in Europe; see below.
    Controlled experiments on cell lines and mice (with D. Givol, V. Rotter, Y. Groner, L. Sachs; D. Gazit (Hadassa))
    Development of antigen chips, applications for autoimmune diseases (with I. Cohen)
    Studies human cancer samples; leukemia (with E. Canaani; G. Rechavi S. Izraeli (Sheba))
    Colorectal cancer; (with D. Notterman (UMDNJ), F. Barany (Cornell), P. Paty (MSK), A. Levine (Princeton))
    Prostate cancer; (with Z. Eshhar, A. Orr (TA Sourasky));
    Glioblastoma; (with M. Hegi, R. Stupp (CHUV))
    Breast and cervical cancer (with J-P Thiery, F. Radvanyi, X. Sastre, C. Rosty (Inst Curie))

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  • Picture of Prof. Eytan Domany

    Prof. Eytan Domany

    Computational Physics: equilibrium and non-equilibrium statistical mechanics of spin glasses
    Collaboration with:  A. P. Young (UCSC)
    Development of tools and algorithms for large scale data analysis. Bioinformatics.
    Analysis of high-throughput biological data (in particular, gene expression data)
    Collaboration with:  Several research groups at Weizmann, in the USA and in Europe; see below.
    Controlled experiments on cell lines and mice (with D. Givol, V. Rotter, Y. Groner, L. Sachs; D. Gazit (Hadassa))
    Development of antigen chips, applications for autoimmune diseases (with I. Cohen)
    Studies human cancer samples; leukemia (with E. Canaani; G. Rechavi S. Izraeli (Sheba))
    Colorectal cancer; (with D. Notterman (UMDNJ), F. Barany (Cornell), P. Paty (MSK), A. Levine (Princeton))
    Prostate cancer; (with Z. Eshhar, A. Orr (TA Sourasky));
    Glioblastoma; (with M. Hegi, R. Stupp (CHUV))
    Breast and cervical cancer (with J-P Thiery, F. Radvanyi, X. Sastre, C. Rosty (Inst Curie))

    Homepage
  • Picture of Prof. Idit Shachar

    Prof. Idit Shachar

    Analyze the pathway regulateing the survival cascades in Chronic lymphocytic leukemia
    Collaboration with:  Dr Michal Haran, Kaplan Medical center
    Follow the mechanisms controlling homing of immune cells in health and disease.
    Determine the mechanisms regulating peripheral B cell maturation and survival in health and disease.

    Homepage
  • Picture of Dr. Valery Krizhanovsky

    Dr. Valery Krizhanovsky

    The role of cellular senescence in human disease
    Mechanisms of interaction of senescent cells with their microenvironment
    Cellular senescence in cancer development and treatment

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