Publications

Book

 

Milo R, Phillips R (2016). Cell Biology by the Numbers (Garland Science). read online.

Publications

2017

86.
Elad Herz; Niv Antonovsky; Yinon Bar-On; Dan Davidi; Shmuel Gleizer; Noam Prywes; Lianet Noda-Garcia; Keren Lyn Frisch; Yehudit Zohar; David G. Wernick; Alon Savidor; Uri Barenholz; Ron Milo (2017). The genetic basis for the adaptation of E-coli to sugar synthesis from CO2.  Nat Commun. 8.  Abstract
85.
Niv Antonovsky; Shmuel Gleizer; Ron Milo (2017). Engineering carbon fixation in E. coil: from heterologous RuBisCO expression to the Calvin-Benson-Bassham cycle: from heterologous RuBisCO expression to the Calvin-Benson-Bassham cycle.  Current Opinion in Biotechnology. 47:83-91.  Abstract
84.
Dan Davidi; Ron Milo (2017). Lessons on enzyme kinetics from quantitative proteomics.  Current Opinion in Biotechnology. 46:81-89.  Abstract
83.
Gita Mahmoudabadi; Ron Milo; Rob Phillips (2017). Energetic cost of building a virus.  Proceedings of the National Academy of Sciences of the United States of America. 114:(22)E4324-E4333.  Abstract
82.
Uri Barenholz; Dan Davidi; Ed Reznik; Yinon Bar-On; Niv Antonovsky; Elad Noor; Ron Milo (2017). Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points.  eLife. 6.  Abstract

2016

81.
Elad Noor; Abraham Flamholz; Arren Bar-Even; Dan Davidi; Ron Milo; W Liebermeister (2016). The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization.  PLOS Computational Biology. 12:(11)  Abstract
80.
Alon Shepon; Gil Eshel; Elad Noor; Ron Milo (2016). Energy and protein feed-to-food conversion efficiencies in the US and potential food security gains from dietary changes.  Environmental Research Letters. 11:(10)  Abstract
79.
Niall M. Mangan; Avi Flamholz; Rachel D. Hood; Ron Milo; David F. Savage (2016). pH determines the energetic efficiency of the cyanobacterial CO2 concentrating mechanism.  Proceedings of the National Academy of Sciences of the United States of America. 113:(36)E5354-E5362.  Abstract
78.
Leeat Keren; Jean Hausser; Maya Lotan-Pompan; Slutskin, Ilya Vainberg Slutskin; Hadas Alisar; Sivan Kaminski; Adina Weinberger; Uri Alon; Ron Milo; Eran Segal (2016). Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness.  Cell. 166:(5)1282-1294.e18.  Abstract
77.
Gidon Eshel; Alon Shepon; Elad Noor; Ron Milo (2016). Environmentally Optimal, Nutritionally Aware Beef Replacement Plant-Based Diets.  Environmental Science & Technology. 50:(15)8164-8.  Abstract
76.
Ron Sender; Shai Fuchs; Ron Milo (2016). Revised Estimates for the Number of Human and Bacteria Cells in the Body.  PLoS Biology. 14:(8)e1002533.  Abstract
75.
Niv Antonovsky; Shmuel Gleizer; Elad Noor; Yehudit Zohar; Elad Herz; Uri Barenholz; Lior Zelcbuch; Shira Amram; Aryeh Wides; Naama Tepper; Dan Davidi; Yinon Bar-On; Tasneem Bareia; David G. Wernick; Ido Shani; Sergey Malitsky; Ghil Jona; Arren Bar-Even; Ron Milo (2016). Sugar Synthesis from CO2 in Escherichia coli.  Cell. 166:(1)115-125.  Abstract

media coverage: Haarretz

74.
Lior Zelcbuch; Steffen N. Lindner; Yonatan Zegman; Ilya Vainberg Slutskin; Niv Antonovsky; Shmuel Gleizer; Ron Milo; Arren Bar-Even (2016). Pyruvate Formate-Lyase Enables Efficient Growth of Escherichia coli on Acetate and Formate.  Biochemistry. 55:(17)2423-2426.  Abstract
73.
Davidi, D; Noor, E; Liebermeister, W; Bar-Even, A; Flamholz, A; Tummler, K; Barenholz, U; Goldenfeld, M; Shlomi, T;Milo, R (2016). Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro kcat measurements.  PNAS. 113.  Abstract

media coverage: F1000Prime

72.
Uri Barenholz; Leeat Keren; Eran Segal; Ron Milo (2016). A Minimalistic Resource Allocation Model to Explain Ubiquitous Increase in Protein Expression with Growth Rate.  PLoS One. 11:(4)e0153344.  Abstract
71.
Maya Shamir; Ron Milo; Yinon Bar-On (2016). SnapShot: Timescales in Cell Biology.  CELL. 164.
70.
Ron Sender; Shai Fuchs; Ron Milo (2016). Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans.  Cell. 164:(3)337-340.  Abstract

media coverage: The New York Times, Nature, Listen

2015

69.
Arren Bar-Even; Ron Milo; Elad Noor; Dan Tawfik (2015). The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness.  BIOCHEMISTRY. 54:(32)
68.
Gidon Eshel; Alon Shepon; Tamar Makov; Ron Milo (2015). Reply to Tichenor: Proposed update to beef greenhouse gas footprint is numerically questionable and well within current uncertainty bounds.  Proceedings of the National Academy of Sciences of the United States of America. 112:(8)E822-E823.

media coverage: BBCNational GeographicListen

67.
Gil Eshel; Alon Shepon; T. Makov; Ron Milo (2015). Partitioning United States' feed consumption among livestock categories for improved environmental cost assessments.  Journal of Agricultural Science. 153:(3)432-445.  Abstract
66.
Leeat Keren; Dijk, David Van Dijk; Shira Weingarten-Gabbay; Dan Davidi; Ghil Jona; Adina Weinberger; Ron Milo; Eran Segal (2015). Noise in gene expression is coupled to growth rate.  Genome Research. 25:(12)1893-902.  Abstract
65.
Lior Zelcbuch; Manuel Razo-Mejia; Elad Herz; Sagit Yahav; Niv Antonovsky; Hagar Kroytoro; Ron Milo; Arren Bar-Even (2015). An In Vivo Metabolic Approach for Deciphering the Product Specificity of Glycerate Kinase Proves that Both E. coli's Glycerate Kinases Generate 2-Phosphoglycerate.  PLoS One. 10:(3)  Abstract

2014

64.
Gidon Eshel; Alon Shepon; Tamar Makov; Ron Milo (2014). Land, irrigation water, greenhouse gas, and reactive nitrogen burdens of meat, eggs, and dairy production in the United States.  Proceedings of the National Academy of Sciences of the United States of America. 111:(33)11996-12001.  Abstract
63.
Wolfram Liebermeister; Elad Noor; Avi Flamholz; Dan Davidi; Joerg Bernhardt; Ron Milo (2014). Visual account of protein investment in cellular functions.  Proceedings of the National Academy of Sciences of the United States of America. 111:(23)8488-8493.  Abstract
62.
Gidon Eshel; Alon Shepon; Tamar Makov; Ron Milo (2014). Reply to Metson et al.: The importance of phosphorus perturbations.  Proceedings of the National Academy of Sciences of the United States of America. 111:(46)E4908-E4908.
61.
Avi Flamholz; Rob Phillips; Ron Milo (2014). The quantified cell.  Molecular Biology of the Cell. 25:(22)3497-3500.  Abstract
60.
Shlomit Farkash-Amar; Anat Zimmer; Eran Eden; Ariel Cohen; Zatorsky, Naama Geva Zatorsky; Lydia Cohen; Ron Milo; Alex Sigal; Tamar Danon; Uri Alon (2014). Noise Genetics: Inferring Protein Function by Correlating Phenotype with Protein Levels and Localization in Individual Human Cells.  PLoS Genetics. 10:(3)  Abstract
59.
Elad Noor; Arren Bar-Even; Abraham Flamholz; E Reznik; W Liebermeister; Ron Milo (2014). Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism.  PLoS Computational Biology. 10:(2)  Abstract

2013

58.
Naama Tepper; Elad Noor; Daniel Amador-Noguez; Hulda S. Haraldsdottir; Ron Milo; Josh Rabinowitz; Wolfram Liebermeister; Tomer Shlomi (2013). Steady-State Metabolite Concentrations Reflect a Balance between Maximizing Enzyme Efficiency and Minimizing Total Metabolite Load.  PLoS One. 8:(9)  Abstract
57.
Elad Noor; Hulda S. Haraldsdottir; Ron Milo; Ronan M. T. Fleming (2013). Consistent Estimation of Gibbs Energy Using Component Contributions.  PLoS Computational Biology. 9:(7)  Abstract
56.
Alon Shepon; Tamar Israeli; Gidon Eshel; Ron Milo (2013). EcoTime-An intuitive quantitative sustainability indicator utilizing a time metric.  Ecological Indicators. 24:240-245.  Abstract
55.
Karp, Ayelet Levin Karp; Uri Barenholz; Tasneem Bareia; Michal Dayagi; Lior Zelcbuch; Niv Antonovsky; Elad Noor; Ron Milo (2013). Quantifying Translational Coupling in E. coli Synthetic Operons Using RBS Modulation and Fluorescent Reporters.  ACS Synthetic Biology. 2:(6)327-336.  Abstract
54.
Ron Milo (2013). What is the total number of protein molecules per cell volume? A call to rethink some published values.  BioEssays. 35:(12)1050-1055.  Abstract
53.
Leeat Keren; Ora Zackay; Maya Lotan-Pompan; Uri Barenholz; Erez Dekel; Vered Sasson; Guy Aidelberg; Anat Bren; Danny Zeevi; Adina Weinberger; Uri Alon; Ron Milo; Eran Segal (2013). Promoters maintain their relative activity levels under different growth conditions.  Molecular Systems Biology. 9.  Abstract
52.
Arren Bar-Even; Elad Noor; Avi Flamholz; Ron Milo (2013). Design and analysis of metabolic pathways supporting formatotrophic growth for electricity-dependent cultivation of microbes.  Biochimica Et Biophysica Acta-Bioenergetics. 1827:(9-Aug)1039-1047.  Abstract
51.
Avi Flamholz; Elad Noor; Arren Bar-Even; Wolfram Liebermeister; Ron Milo (2013). Glycolytic strategy as a tradeoff between energy yield and protein cost.  Proceedings of the National Academy of Sciences of the United States of America. 110:(24)10039-10044.  Abstract
50.
Elad Noor; Avi Flamholz; Wolfram Liebermeister; Arren Bar-Even; Ron Milo (2013). A note on the kinetics of enzyme action: A decomposition that highlights thermodynamic effects.  FEBS Letters. 587:(17)2772-2777.  Abstract
49.
Lior Zelcbuch; Niv Antonovsky; Arren Bar-Even; Karp, Ayelet Levin Karp; Uri Barenholz; Michal Dayagi; Wolfram Liebermeister; Avi Flamholz; Elad Noor; Shira Amram; Alexander Brandis; Tasneem Bareia; Ido Yofe; Halim Jubran; Ron Milo (2013). Spanning high-dimensional expression space using ribosome-binding site combinatorics.  Nucleic Acids Research. 41:(9)  Abstract

2012

48.
Ron Milo; Robert L. Last (2012). Achieving Diversity in the Face of Constraints: Lessons from Metabolism.  Science. 336:(6089)1663-1667.  Abstract
47.
Elad Noor; Nathan E. Lewis; Ron Milo (2012). A proof for loop-law constraints in stoichiometric metabolic networks.  BMC Systems Biology. 6.  Abstract
46.
Elad Noor; Ron Milo (2012). Efficiency in Evolutionary Trade-Offs.  Science. 336:(6085)1114-1115.
45.
Roi Adadi; Benjamin Volkmer; Ron Milo; Matthias Heinemann; Tomer Shlomi (2012). Prediction of Microbial Growth Rate versus Biomass Yield by a Metabolic Network with Kinetic Parameters.  PLoS Computational Biology. 8:(7)  Abstract
44.
Arren Bar-Even; Avi Flamholz; Elad Noor; Ron Milo (2012). Rethinking glycolysis: on the biochemical logic of metabolic pathways.  Nature Chemical Biology. 8:(6)509-517.  Abstract
43.
Shlomit Farkash-Amar; Eran Eden; Ariel Cohen; Zatorsky, Naama Geva Zatorsky; Lydia Cohen; Ron Milo; Alex Sigal; Tamar Danon; Uri Alon (2012). Dynamic Proteomics of Human Protein Level and Localization across the Cell Cycle.  PLoS One. 7:(11)  Abstract
42.
Arren Bar-Even; Avi Flamholz; Elad Noor; Ron Milo (2012). Thermodynamic constraints shape the structure of carbon fixation pathways.  Biochimica Et Biophysica Acta-Bioenergetics. 1817:(9)1646-1659.  Abstract
41.
Arren Bar-Even; Elad Noor; Ron Milo (2012). A survey of carbon fixation pathways through a quantitative lens.  Journal of Experimental Botany. 63:(6)2325-2342.  Abstract
40.
Avi Flamholz; Elad Noor; Arren Bar-Even; Ron Milo (2012). eQuilibrator-the biochemical thermodynamics calculator.  Nucleic Acids Research. 40:(D1)D770-D775.  Abstract
39.
Elad Noor; Arren Bar-Even; Avi Flamholz; Yaniv Lubling; Dan Davidi; Ron Milo (2012). An integrated open framework for thermodynamics of reactions that combines accuracy and coverage.  Bioinformatics. 28:(15)2037-2044.  Abstract

2011

38.
Alex Sigal; Jocelyn T. Kim; Alejandro B. Balazs; Erez Dekel; Avi Mayo; Ron Milo; David Baltimore (2011). Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy.  Nature. 477:(7362)95-U100.  Abstract
37.
Ariella Alperovitch-Lavy; Itai Sharon; Forest Rohwer; Eva-Mari Aro; Fabian Glaser; Ron Milo; Nathan Nelson; Oded Beja (2011). Reconstructing a puzzle: existence of cyanophages containing both photosystem-I and photosystem-II gene suites inferred from oceanic metagenomic datasets.  Environmental Microbiology. 13:(1)24-32.  Abstract
36.
Yuval Hart; Avraham E. Mayo; Ron Milo; Uri Alon (2011). Robust Control of PEP Formation Rate in the Carbon Fixation Pathway of C-4 Plants by a Bifunctional Enzyme.  BMC Systems Biology. 5.  Abstract
35.
Arren Bar-Even; Elad Noor; Avi Flamholz; Joerg M. Buescher; Ron Milo (2011). Hydrophobicity and Charge Shape Cellular Metabolite Concentrations.  PLoS Computational Biology. 7:(10)  Abstract
34.
Arren Bar-Even; Elad Noor; Yonatan Savir; Wolfram Liebermeister; Dan Davidi; Dan Tawfik; Ron Milo (2011). The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters.  Biochemistry. 50:(21)4402-4410.  Abstract

2010

33.
Uri Moran; Rob Phillips; Ron Milo (2010). SnapShot: Key Numbers in Biology.  Cell. 141:(7)1262-1262.
32.
Ron Milo; Paul Jorgensen; Uri Moran; Griffin Weber; Michael Springer (2010). BioNumbers-the database of key numbers in molecular and cell biology.  Nucleic Acids Research. 38:D750-D753.  Abstract
31.
Elad Noor; Eran Eden; Ron Milo; Uri Alon (2010). Central Carbon Metabolism as a Minimal Biochemical Walk between Precursors for Biomass and Energy.  Molecular Cell. 39:(5)809-820.  Abstract
30.
Zatorsky, Naama Geva Zatorsky; A. A. Cohen; Eran Eden; Erez Dekel; Milana Frenkel-Morgenstern; Irina Issaeva; Tamar Danon; Liron Cohen; N. Perzov; Ron Milo; A. Sigal; Uri Alon (2010). Dynamics proteomics of individual cancer cells in response to drugs.  Febs Journal. 277:281-281.
29.
Yonatan Savir; Elad Noor; Ron Milo; Tsvi Tlusty (2010). Cross-species analysis traces adaptation of Rubisco toward optimality in a low-dimensional landscape.  Proceedings of the National Academy of Sciences of the United States of America. 107:(8)3475-3480.  Abstract
28.
Arren Bar-Even; Elad Noor; Nathan E. Lewis; Ron Milo (2010). Design and analysis of synthetic carbon fixation pathways.  Proceedings of the National Academy of Sciences of the United States of America. 107:(19)8889-8894.  Abstract

2009

27.
Ron Milo; Maya Schuldiner (2009). Weizmann Young PI Forum: The Power of Peer Support.  Molecular Cell. 36:(6)913-915.
26.
Rob Phillips; Ron Milo (2009). A feeling for the numbers in biology.  Proceedings of the National Academy of Sciences of the United States of America. 106:(51)21465-21471.  Abstract
25.
Ron Milo (2009). What governs the reaction center excitation wavelength of photosystems I and II?.  Photosynthesis Research. 101:(1)59-67.  Abstract
24.
Ariel Cohen; Tomer Kalisky; Avi Mayo; Zatorsky, Naama Geva Zatorsky; Tamar Danon; Irina Issaeva; Ronen Benjamine Kopito; Natalie Perzov; Ron Milo; Alex Sigal; Uri Alon (2009). Protein Dynamics in Individual Human Cells: Experiment and Theory.  PLoS One. 4:(4)  Abstract

2008

23.
A. A. Cohen; Zatorsky, Naama Geva Zatorsky; Eran Eden; Milana Frenkel-Morgenstern; Irina Issaeva; A. Sigal; Ron Milo; Cellina Cohen-Saidon; Yuvalal Liron; Zvi Kam; Liron Cohen; Tamar Danon; N. Perzov; Uri Alon (2008). Dynamic Proteomics of Individual Cancer Cells in Response to a Drug.  Science. 322:(5907)1511-1516.  Abstract

2007

22.
Ron Milo (2007). The relationship between evolutionary and physiological variation in hemoglobin.  PNAS. 104.  Abstract
21.
Ivo Spiegel; Konstantin Adamsky; Yael Eshed; Ron Milo; Helena Sabanay; Offra Sarig-Nadir; Ido Horresh; Steven S. Scherer; Matthew N. Rasband; Elior Peles (2007). A central role for Necl4 ( SynCAM4) in Schwann cell- axon interaction and myelination.  Nature Neuroscience. 10:(7)861-869.  Abstract
20.
Guy Shinar; Ron Milo; Maria Rodriguez Martinez; Uri Alon (2007). Input-output robustness in simple bacterial signaling systems.  Proceedings of the National Academy of Sciences of the United States of America. 104:(50)19931-19935.  Abstract
19.
Alex Sigal; Tamar Danon; Ariel Cohen; Ron Milo; Zatorsky, Naama Geva Zatorsky; Gila Lustig; Yuvalal Liron; Uri Alon; Natalie Perzov (2007). Generation of a fluorescently labeled endogenous protein library in living human cells.  Nature Protocols. 2:(6)1515-1527.  Abstract
18.
Ronen Zaidel-Bar; Ron Milo; Zvi Kam; Benjamin Geiger (2007). A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions.  Journal of Cell Science. 120:(1)137-148.  Abstract

2006

17.
A Sigal; Ron Milo; Ayala Cohen; Zatorsky, Naama Geva Zatorsky; Yasmin A. Klein; I Alaluf; N Swerdlin; N Perzov; Tamar Danon; Yuvalal Liron; T Raveh; AE Carpenter; G Lahav; Uri Alon (2006). Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.  Nature Methods. 3:(7)525-531.  Abstract
16.
Zatorsky, Naama Geva Zatorsky; Nitzan Rosenfeld; Shalev Itzkovitz; Ron Milo; Alex Sigal; Erez Dekel; Talia Yarnitzky; Yuvalal Liron; Paz Polak; Galit Lahav; Uri Alon (2006). Oscillations and variability in the p53 system.  Molecular Systems Biology. 2.  Abstract
15.
Alex Sigal; Ron Milo; Ariel Cohen; Zatorsky, Naama Geva Zatorsky; Yael Klein; Yuvalal Liron; Nitzan Rosenfeld; Tamar Danon; Natalie Perzov; Uri Alon (2006). Variability and memory of protein levels in human cells.  Nature. 444:(7119)643-646.  Abstract
14.
Shalev Itzkovitz; Ron Milo; Nadav Kashtan; Reuven Levitt; Amir Lahav; Uri Alon (2006). Recurring harmonic walks and network motifs in Western music.  Advances in Complex Systems. 9:(2-Jan)121-132.  Abstract

2005

13.
Shalev Itzkovitz; R Levitt; N Kashtan; Ron Milo; M Itzkovitz; Uri Alon (2005). Coarse-graining and self-dissimilarity of complex networks.  Physical Review E. 71:(1)  Abstract

2004

12.
Rosbo, NK de Rosbo; JF Kaye; Miriam Eisenstein; W Mendel; R Hoeftberger; H Lassmann; Ron Milo; Avi Ben-Nun (2004). The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501.  Journal of Immunology. 173:(2)1426-1435.  Abstract
11.
de Rosbo, NK; Kaye, JF; Eisenstein, M; Mendel, W; Hoeftberger, R; Lassmann, H; Milo, R; Ben-Nun, A (2004). The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501.  Journal Of Immunology. 173:1426-1435.  Abstract
10.
E Yeger-Lotem; S Sattath; N Kashtan; Shalev Itzkovitz; Ron Milo; RY Pinter; Uri Alon; H Margalit (2004). Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction.  Proceedings of the National Academy of Sciences of the United States of America. 101:(16)5934-5939.  Abstract
9.
Shalev Itzkovitz; Ron Milo; N Kashtan; MEJ Newman; Uri Alon (2004). Reply to "Comment on 'Subgraphs in random networks' ".  Physical Review E. 70:(5)  Abstract
8.
N Kashtan; Shalev Itzkovitz; Ron Milo; Uri Alon (2004). Efficient sampling algorithm for estimating subgraph concentrations and detecting network motifs.  Bioinformatics. 20:(11)1746-1758.  Abstract
7.
N Kashtan; Shalev Itzkovitz; Ron Milo; Uri Alon (2004). Topological generalizations of network motifs.  Physical Review E. 70:(3)  Abstract
6.
Ron Milo; Shalev Itzkovitz; N Kashtan; R Levitt; Uri Alon (2004). Response to comment on "network motifs: Simple building blocks of complex networks" and "superfamilies of evolved and designed networks".  Science. 305:(5687)
5.
Ron Milo; Shalev Itzkovitz; N Kashtan; R Levitt; S Shen-Orr; I Ayzenshtat; Michal Sheffer; Uri Alon (2004). Superfamilies of evolved and designed networks.  Science. 303:(5663)1538-1542.  Abstract

2003

4.
Shalev Itzkovitz; Ron Milo; N Kashtan; G Ziv; Uri Alon (2003). Subgraphs in random networks.  Physical Review E. 68:(2)  Abstract

2002

3.
SS Shen-Orr; Ron Milo; S Mangan; Uri Alon (2002). Network motifs in the transcriptional regulation network of Escherichia coli.  Nature Genetics. 31:(1)64-68.  Abstract
2.
Shen-Orr, SS; Milo, R; Mangan, S; Alon, U (2002). Network motifs in the transcriptional regulation network of Escherichia coli.  Nature Genetics. 31:64-68.  Abstract
1.
Ron Milo; S Shen-Orr; Shalev Itzkovitz; N Kashtan; D Chklovskii; Uri Alon (2002). Network motifs: Simple building blocks of complex networks.  Science. 298:(5594)824-827.  Abstract