Host-virus interactions

We investigate the interaction between the bloom-forming coccolithophore E. huxleyi and its specific virus, EhV, on the cellular and molecular levels. In the lab, we develop state-of-the-art tools to track this interaction across scales – from the single-cell level to vast oceanic blooms. We have established high throughput methods to study the genomics, physiology, and metabolism of E. huxleyi during viral infection. 


Research projects in the lab:

1) The cellular defense mechanisms against viruses in marine algae.

Host-virus dynamics, showing coccolithophore population demise followed by recovery of a resistant host sub-population.

2) Investigating the metabolic footprint of viral infection in the ocean by applying exo-metabolomics and MALDI-imaging.

Targeted mass spectrometry imaging of known lipid biomarkers reveals the metabolic landscape produced during viral infection. From:  Schleyer G. et al, 2019, Nature Microbiology

3) Communication during viral infection via secretion of extracellular vesicles.

The ecological significance of extracellular vesicles in modulating host-virus interactions during algal blooms. See also Schatz et al, Nature Micriobiology 2017, Schatz et al. ISME J 2021