The main goal of our group is to decipher the first principles of cellular self-organization processes such as protein folding, protein-protein
assembly, and protein-DNA recognition. We are focused on advancing our understanding of biomolecules (the sequence-structure-function problem) using a battery of computational and theoretical methods that capture their chemical and physical nature as well as the billions of years of evolutional design.
Protein folding has long been viewed as being rich in complexities. With the development of the energy landscape theory, our view of protein folding has greatly simplified. ... read more
Biological molecules rarely function in isolation, hence a thorough understanding of biological processes is dependent upon an examination of complexes of biomolecules, and the interactions between complexes. ... read more
Essentially, most of the biological functions of DNA require the binding of specific proteins to specific DNA sequences. For binding to occur, the protein has to discriminate between many similar and competing binding sites. ... read more
