The main goal of our group is to decipher the first principles of cellular self-organization processes such as protein folding, protein-protein assembly, and protein-DNA recognition. We are focused on advancing our understanding of biomolecules (the sequence-structure-function problem) using a battery of computational and theoretical methods that capture their chemical and physical nature as well as the billions of years of evolutional design.
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Lastest Publication
The Origins and Evolution of Ubiquitination Sites
. Hagai T, Toth-Petroczy A, Azia A, Levy Y,. 2012 Molecular Biosystems, 8: 1865-1877
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Intrinsically Disordered Regions as Affinity Tuners in Protein-DNA Interactions
. Vuzman D, Levy Y,. 2012 Molecular Biosystems, 8: 47-57
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Asymmetrical Roles of Zinc Fingers in Dynamic DNA-Scanning Process by the Inducible Transcription Factor Egr-1
. Zandarashvili L, Vuzman D, Esadze A, Takayama Y, Sahu D, Levy Y, Iwahara J,. 2012 Proc Nat Acad Sci USA, 109: E1724-E1732
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Fields of Interest
Protein Folding and Post-translational Modifications
Protein folding has long been viewed as being rich in complexities. With the development of the energy landscape theory, our view of protein folding, however, has...
Protein-Protein Assembly
Biomolecules rarely function in isolation, hence a thorough understanding of biological processes is dependent upon an examination of complexes of biomolecules, and...
Protein-DNA recognition
Essentially, most of the biological functions of DNA require the binding of specific proteins to specific DNA sequences. For binding to occur, the protein has to...