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Proteins mediate nearly all of the essential molecular processes of life. To perform their function, they need to fold into unique structures. At any given moment, thousands of proteins are produced and need to fold in the cell. But folding is an incredibly complex process that very often fails. To deal with this challenge, the cell is equipped with an array of chaperones and proteases, performing quality control functions to safeguard the cell. Failure of these processes underlies numerous devastating diseases. We investigate how these events unfold for membrane proteins, which are proteins that reside at the membrane and make up a quarter of the proteome in every living organism.