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Macromolecular machineries residing within our cells mediate every aspect of cellular physiology in both health and disease. These machineries adopt complicated three-dimensional (3D) structures that are critical to their function. Our lab focuses on visualizing the complex architectures of macromolecular assemblies, with the aim of learning how their complicated structures contribute to their ability to mediate cellular functions. To do this we use a combination of structural, biophysical and biochemical techniques with an emphasis on high-resolution electron cryo- microscopy (cryo-EM).