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Research Aims

Constrained peptides for functional antibody development

Structure and function of the proteasome regulatory particle

Ubiquitin as a multistage tag

Rerouting proteasomal substrates to lysosomal degradation is reflected in reprograming the repertoire of antigens associated with MHC class I and class II

Differential translocation of substrates to proteasomal degradation affects antigen presentation and thus T cell activation