Main questions

  • How bacteria regulate different virulence strategies to optimize pathogenicity in the host environment.
  • How do innate immune cells recognize pathogens, integrate signals from bacterial PAMPs and determine cell fate.
  • Ongoing improvement of the methodologies we apply to study host-pathogen interactions.
  • Characterize the in vivo landscape of infection at a resolution of individual host-pathogen encounters: what are the infection 'bottlenecks', what are the cell population that expand in different tissues?

Watch the following presentation, describing our latest work: