In vivo models of infection
Analyzing the early events of in vivo infection using single cell technologies
Research
Main questions
- How bacteria regulate different virulence strategies to optimize pathogenicity in the host environment.
- How do innate immune cells recognize pathogens, integrate signals from bacterial PAMPs and determine cell fate.
- Ongoing improvement of the methodologies we apply to study host-pathogen interactions.
- Characterize the in vivo landscape of infection at a resolution of individual host-pathogen encounters: what are the infection 'bottlenecks', what are the cell population that expand in different tissues?
Watch the following presentation, describing our latest work:
In vitro models of infection
Using single-cell methods to analyze the heterogeneity during macrophages infection with Salmonella enterica