Effects of antibiotics on immunometabolism

Antibiotics have been studied for decades for their antimicrobial activity, yet their effects on host immunity remain incompletely understood. In our lab, we have discovered that antibiotics can directly modulate immune responses in a cell type– and activation state–dependent manner through targeting conserved mitochondrial pathways.

Our goal is to develop a comprehensive, mechanistic understanding of how antibiotics reshape immunometabolism and immune function during infection. Because antibiotics are widely used across clinical and biomedical settings, our work aims to inform immunity-aware antibiotic treatment strategies that optimize host defense while minimizing unintended immune effects.