Human population-level infection dynamics

A defining feature of human infection is that only a subset of individuals exposed to a pathogen develops clinical disease—a complexity that cannot be fully captured in animal models. In addition, many important pathogens, including Salmonella Typhi, are restricted to humans and therefore cannot be studied using conventional animal systems.

To overcome these limitations, we use computational approaches together with controlled human infection models to study immune responses across diverse human cohorts , Ben-Moshe et al., 2025, Ben-Moshe et al., 2019). By capturing variation in immune dynamics at the population level, we aim to uncover how human immune cells respond to infection, interact with intracellular pathogens, and shape early infection outcomes, revealing new principles of human infection biology.