Monocytes are mononuclear phagocytes that circulate in the blood and comprise two major subsets. One monocyte population seems dedicated to patrol the inner vessel wall and surveille it for integrity. A second subset, defined as CD14+ cells and Ly6C+ cells in man and mouse respectively, is highly dynamic and short-lived. These cells can be recruited to sites of inflammation and injury where they give rise to monocyte-derived DC and macrophages. Differential functions of these cells and classical tissue-resident DC and macrophages remain largely to be defined.
Publications:
Geissman, Jung and Littman Immunity 2002
Landsman et al. JI 2007
Varol et al. JExMed 2007
Landsman et al. Blood 2009
Yona et. Immunity 2012
Mildner & Jung. Adv. Immunol 2013
(review)
Avraham, Yona et al. JExMed 2013
Molawi, Wolf et al JExMed 2014
Mildner, Marinkovic and Jung. Microbiol. Spectrum 2016 (review)
Shmuel-Galia*, Aychek* et al. EMBO 2016, collab. with Yehiel Shai
Wolf et al. JExMed 2017
Mildner et al. Immunity 2017
Gross-Vered*, Shmuel-Galia* et al J Immunology 2019 collab. with Yehiel Shai
Gross-Vered et al. eLife 2020
Trzebanski & Jung. Imm. Letters 2020
Past and present Jung lab members involved in these studies:
Limor Landsman, Simon Yona, Ki-Wook Kim, Yochai Wolf, Alexander Mildner, Mor Gross, Sebastien Trzebanski, Anmol Kulkarni.
Past and Current Funding:
DFG (FOR 1336-2); BSF, ISF, MINERVA foundation, AdvERC