Publications

All years

2019

A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

Read more about

Publication category: Cancer Immunotherapy

, Open in new window

Authors: Khoo W. H. Ledergor G., Weiner A., Roden D. L., Terry R. L., McDonald M. M., Chai R. C., De Veirman K., Owen K. L., Opperman K. S., Vandyke K., Clark J. R., Seckinger A., Kovacic N., Nguyen A., Mohanty S. T., Pettitt J. A., Xiao Y., Corr A. P., Seeliger C., Novotny M., Lasken R. S., Nguyen T., Oyajobi B. O., Aftab D., Swarbrick A., Parker B., Hewett D. R., Hose D., Vanderkerken K., Zannettino A. C. W., Amit I., Phan T. G. & Croucher P., et al. Blood | 2019 [All authors] »

A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

Read more about

Publication category: Development

, Open in new window

Authors: Rojo R. Raper A., Ozdemir D. D., Lefevre L., Grabert K., Wollscheid-Lengeling E., Bradford B., Caruso M., Gazova I., Sanchez A., Lisowski Z. M., Alves J., Molina-Gonzalez I., Davtyan H., Lodge R. J., Glover J. D., Wallace R., Munro D. A. D., David E., Amit I., Miron V. E., Priller J., Jenkins S. J., Hardingham G. E., Blurton-Jones M., Mabbott N. A., Summers K. M., Hohenstein P., Hume D. A. & Pridans C., et al. Nature Communications | 2019 [All authors] »

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

Plasmacytoid dendritic cells develop from Ly6D(+) lymphoid progenitors distinct from the myeloid lineage

Read more about

Publication category: Development

, Open in new window

Authors: Dress R. J. Dutertre C., Giladi A., Schlitzer A., Low I., Shadan N. B., Tay A., Lum J., Kairi M. F. B. M., Hwang Y. Y., Becht E., Cheng Y., Chevrier M., Larbi A., Newell E. W., Amit I., Chen J. & Ginhoux F., et al. Nature Immunology | 2019 [All authors] »

Plasmacytoid dendritic cells develop from Ly6D(+) lymphoid progenitors distinct from the myeloid lineage

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

Read more about

Publication category: Metabolism

, Open in new window

Authors: Jaitin D. A., Adlung L., Thaiss C. A., Weiner A., Li B. Descamps H., Lundgren P., Bleriot C., Liu Z., Deczkowska A., Keren-Shaul H., David E., Zmora N., Eldar S. M., Lubezky N., Shibolet O., Hill D. A., Lazar M. A., Colonna M., Ginhoux F., Shapiro H., Elinav E. & Amit I., et al. Cell | 2019 [All authors] »

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress

Read more about

Publication category: Brain

, Open in new window

Authors: Kertser A. Baruch K., Deczkowska A., Weiner A., Croese T., Kenigsbuch M., Cooper I., Tsoory M., Ben-Hamo S., Amit I. & Schwartz M., et al. Science advances | 2019 [All authors] »

Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress

MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing

Read more about

Publication category: Technology

, Open in new window

Authors: Keren-Shaul H. Kenigsberg E., Jaitin D. A., David E., Paul F., Tanay A. & Amit I., et al. NATURE PROTOCOLS | 2019 [All authors] »

MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing

Cell composition analysis of bulk genomics using single-cell data

Read more about

Publication category: Technology

, Open in new window

Authors: Frishberg A. Peshes-Yaloz N., Cohn O., Rosentul D., Steuerman Y., Valadarsky L., Yankovitz G., Mandelboim M., Iraqi F. A., Amit I., Mayo L., Bacharach E. & Gat-Viks I., et al. Nature Methods | 2019 [All authors] »

Cell composition analysis of bulk genomics using single-cell data

DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node

Read more about

Publication category: Development

, Open in new window

Authors: Curato C. Bernshtein B., Zupancic E., Dufner A., Jaitin D., Giladi A., David E., Chappell-Maor L., Leshkowitz D., Knobeloch K., Amit I., Florindo H. F. & Jung S., et al. Frontiers in Immunology | 2019 [All authors] »

DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

Read more about

Publication category: Cancer Immunotherapy

, Open in new window

Authors: Li H., van der Leun A. M., Yofe I., Lubling Y. Gelbard-Solodkin D., van Akkooi A. C. J., van den Braber M., Rozeman E. A., Haanen J. B. A. G., Blank C. U., Horlings H. M., David E., Baran Y., Bercovich A., Lifshitz A., Schumacher T. N., Tanay A. & Amit I., et al. Cell | 2019 [All authors] »

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

Read more about

Publication category: Development

, Open in new window

Authors: Zviran A. Mor N., Rais Y., Gingold H., Peles S., Chomsky E., Viukov S., Buenrostro J. D., Scognamiglio R., Weinberger L., Manor Y. S., Krupalnik V., Zerbib M., Hezroni H., Jaitin D. A., Larastiaso D., Gilad S., Benjamin S., Gafni O., Mousa A., Ayyash M., Sheban D., Bayerl J., Aguilera-Castrejon A., Massarwa R., Maza I., Hanna S., Stelzer Y., Ulitsky I., Greenleaf W. J., Tanay A., Trumpp A., Amit I., Pilpel Y., Novershtern N. & Hanna J. H., et al. Cell Stem Cell | 2019 [All authors] »

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity

Read more about

Publication category: Development , Technology

, Open in new window

Authors: Blecher-Gonen R., Bost P., Hilligan K. L. David E., Salame T. M., Roussel E., Connor L. M., Mayer J. U., Halpern K. B., Toth B., Itzkovitz S., Schwikowski B., Ronchese F. & Amit I., et al. Cell Systems | 2019 [All authors] »

Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

Read more about

Publication category: Brain

, Open in new window

Authors: Rosenzweig N., Dvir-Szternfeld R. Tsitsou-Kampeli A., Keren-Shaul H., Ben-Yehuda H., Weill-Raynal P., Cahalon L., Kertser A., Baruch K., Amit I., Weiner A. & Schwartz M., et al. Nature Communications | 2019 [All authors] »

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

2018

Impaired immune surveillance accelerates accumulation of senescent cells and aging

Read more about

Publication category: Metabolism

, Open in new window

Authors: Ovadya Y., Landsberger T. Leins H., Vadai E., Gal H., Biran A., Yosef R., Sagiv A., Agrawal A., Shapira A., Windheim J., Tsoory M., Schirmbeck R., Amit I., Geiger H. & Krizhanovsky V., et al. Nature Communications | 2018 [All authors] »

Impaired immune surveillance accelerates accumulation of senescent cells and aging

Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

Read more about

Publication category: Cancer Immunotherapy

, Open in new window

Authors: Ledergor G., Weiner A. Zada M., Wang S., Cohen Y. C., Gatt M. E., Snir N., Magen H., Koren-Michowitz M., Herzog-Tzarfati K., Keren-Shaul H., Bornstein C., Rotkopf R., Yofe I., David E., Yellapantula V., Kay S., Salai M., Ben Yehuda D., Nagler A., Shvidel L., Orr-Urtreger A., Halpern K. B., Itzkovitz S., Landgren O., San-Miguel J., Paiva B., Keats J. J., Papaemmanuil E., Avivi I., Barbash G. I., Tanay A. & Amit I., et al. Nature Medicine | 2018 [All authors] »

Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

Read more about

Publication category: Development

, Open in new window

Authors: Cohen M., Giladi A., Gorki A. Galbard Solodkin D., Zada M., Hladik A., Miklosi A., Salame T., Halpern K. B., David E., Itzkovitz S., Harkany T., Knapp S. & Amit I., et al. Cell | 2018 [All authors] »

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

From the Human Cell Atlas to dynamic immune maps in human disease

Read more about

Publication category: Technology

, Open in new window

Authors: Adlung L. & Amit I. Nature Reviews Immunology | 2018 [All authors] »

From the Human Cell Atlas to dynamic immune maps in human disease

Combining Developmental and Perturbation-Seq Uncovers Transcriptional Modules Orchestrating Neuronal Remodeling

Read more about

Publication category: Development

, Open in new window

Authors: Alyagor I., Berkun V. Keren-Shaul H., Marmor-Kollet N., David E., Mayseless O., Issman-Zecharya N., Amit I. & Schuldiner O., et al. Developmental Cell | 2018 [All authors] »

Combining Developmental and Perturbation-Seq Uncovers Transcriptional Modules Orchestrating Neuronal Remodeling

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

Read more about

Publication category: Metabolism , Technology

, Open in new window

Authors: Halpern K. B. Shenhav R., Massalha H., Toth B., Egozi A., Massasa E. E., Medgalia C., David E., Giladi A., Moor A. E., Porat Z., Amit I. & Itzkovitz S., et al. Nature Biotechnology | 2018 [All authors] »

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

Early metazoan cell type diversity and the evolution of multicellular gene regulation

Read more about

Publication category: Development

, Open in new window

Authors: Sebe-Pedros A. Chomsky E., Pang K., Lara-Astiaso D., Gaiti F., Mukamel Z., Amit I., Hejnol A., Degnan B. M. & Tanay A., et al. Nature ecology & evolution | 2018 [All authors] »

Early metazoan cell type diversity and the evolution of multicellular gene regulation

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

Read more about

Publication category: Development

, Open in new window

Authors: Giladi A., Paul F. Herzog Y., Lubling Y., Weiner A., Yofe I., Jaitin D., Cabezas-Wallscheid N., Dress R., Ginhoux F., Trumpp A., Tanay A. & Amit I., et al. Nature Cell Biology | 2018 [All authors] »

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

The bone marrow is patrolled by NK cells that are primed and expand in response to systemic viral activation

Read more about

Publication category: Development

, Open in new window

Authors: Milo I. Blecher-Gonen R., Barnett-Itzhaki Z., Bar-Ziv R., Tal O., Gurevich I., Feferman T., Drexler I., Amit I., Bousso P. & Shakhar G., et al. European Journal of Immunology | 2018 [All authors] »

The bone marrow is patrolled by NK cells that are primed and expand in response to systemic viral activation

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

Read more about

Publication category: Development

, Open in new window

Authors: Bornstein C., Nevo S., Giladi A. Kadouri N., Pouzolles M., Gerbe F., David E., Machado A., Chuprin A., Toth B., Goldberg O., Itzkovitz S., Taylor N., Jay P., Zimmermann V. S., Abramson J. & Amit I., et al. Nature | 2018 [All authors] »

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment

Read more about

Publication category: Development

, Open in new window

Authors: Lauridsen F. K. B. Jensen T. L., Rapin N., Aslan D., Wilhelmson A. S., Pundhir S., Rehn M., Paul F., Giladi A., Hasemann M. S., Serup P., Amit I. & Porse B. T., et al. Cell Reports | 2018 [All authors] »

Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment

Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing

Read more about

Publication category: Technology

, Open in new window

Authors: Steuerman Y., Cohen M. Peshes-Yaloz N., Valadarsky L., Cohn O., David E., Frishberg A., Mayo L., Bacharach E., Amit I. & Gat-Viks I., et al. Cell Systems | 2018 [All authors] »

Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing

Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies

Read more about

Publication category: Development

, Open in new window

Authors: Gamliel M. Goldman-Wohl D., Isaacson B., Gur C., Stein N., Yamin R., Berger M., Grunewald M., Keshet E., Rais Y., Bornstein C., David E., Jelinski A., Eisenberg I., Greenfield C., Ben-David A., Imbar T., Gilad R., Haimov-Kochman R., Mankuta D., Elami-Suzin M., Amit I., Hanna J. H., Yagel S. & Mandelboim O., et al. Immunity | 2018 [All authors] »

Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Read more about

Publication category: Brain

, Open in new window

Authors: Deczkowska A., Keren-Shaul H., Weiner A. Colonna M., Schwartz M. & Amit I., et al. Cell | 2018 [All authors] »

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Microglial immune checkpoint mechanisms

Read more about

Publication category: Brain

, Open in new window

Authors: Deczkowska A., Amit I. & Schwartz M. Nature Neuroscience | 2018 [All authors] »

Microglial immune checkpoint mechanisms

Salient experiences are represented by unique transcriptional signatures in the mouse brain

Read more about

Publication category: Brain

, Open in new window

Authors: Mukherjee D. Ignatowska-Jankowska B. M., Itskovits E., Gonzales B. J., Turm H., Izakson L., Haritan D., Bleistein N., Cohen C., Amit I., Shay T., Grueter B., Zaslaver A. & Citri A., et al. eLife | 2018 [All authors] »

Salient experiences are represented by unique transcriptional signatures in the mouse brain

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

Read more about

Publication category: Development , Brain

, Open in new window

Authors: Thion M. S. Low D., Silvin A., Chen J., Grisel P., Schulte-Schrepping J., Blecher R., Ulas T., Squarzoni P., Hoeffel G., Coulpier F., Siopi E., David F. S., Scholz C., Shihui F., Lum J., Amoyo A. A., Larbi A., Poidinger M., Buttgereit A., Lledo P., Greter M., Chan J. K. Y., Amit I., Beyer M., Schultze J. L., Schlitzer A., Pettersson S., Ginhoux F. & Garel S., et al. Cell | 2018 [All authors] »

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

Read more about

Publication category: Technology

, Open in new window

Authors: Giladi A. & Amit I. Cell | 2018 [All authors] »

Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

2017

Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq

Read more about

Publication category: Technology

, Open in new window

Authors: Medaglia C., Giladi A., Stoler-Barak L. De Giovanni M., Salame T. M., Biram A., David E., Li H., Iannacone M., Shulman Z. & Amit I., et al. Science | 2017 [All authors] »

Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

Read more about

Publication category: Brain

, Open in new window

Authors: Deczkowska A., Matcovitch-Natan O. Tsitsou-Kampeli A., Ben-Hamo S., Dvir-Szternfeld R., Spinrad A., Singer O., David E., Winter D. R., Smith L. K., Kertser A., Baruch K., Rosenzweig N., Terem A., Prinz M., Villeda S., Citri A., Amit I. & Schwartz M., et al. Nature Communications | 2017 [All authors] »

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

Immunology, one cell at a time

Read more about

Publication category: Technology

, Open in new window

Authors: Giladi A. & Amit I. Nature | 2017 [All authors] »

Immunology, one cell at a time

MicroRNA-142 controls thymocyte proliferation

Read more about

Publication category: Development , Autoimmunity

, Open in new window

Authors: Mildner A. Chapnik E., Varol D., Aychek T., Lampl N., Rivkin N., Bringmann A., Paul F., Boura-Halfon S., Hayoun Y. S., Barnett Itzhaki I. Z., Amit I., Hornstein E. & Jung S., et al. European Journal of Immunology | 2017 [All authors] »

MicroRNA-142 controls thymocyte proliferation

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Read more about

Publication category: Brain

, Open in new window

Authors: Keren-Shaul H., Spinrad A., Weiner A., Matcovitch-Natan O. Dvir-Szternfeld R., Ulland T. K., David E., Baruch K., Lara-Astaiso D., Toth B., Itzkovitz S., Colonna M., Schwartz M. & Amit I., et al. Cell | 2017 [All authors] »

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

Read more about

Publication category: Development , Brain

, Open in new window

Authors: Varol D. Mildner A., Blank T., Shemer A., Barashi N., Yona S., David E., Boura-Halfon S., Segal-Hayoun Y., Chappell-Maor L., Keren-Shaul H., Leshkowitz D., Hornstein E., Fuhrmann M., Amit I., Maggio N., Prinz M. & Jung S., et al. Immunity | 2017 [All authors] »

Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

Read more about

Publication category: Cancer Immunotherapy

, Open in new window

Authors: Lavin Y. Kobayashi S., Leader A., Amir E. D., Elefant N., Bigenwald C., Remark R., Sweeney R., Becker C. D., Levine J. H., Meinhof K., Chow A., Kim-Shulze S., Wolf A., Medaglia C., Li H., Rytlewski J. A., Emerson R. O., Solovyov A., Greenbaum B. D., Sanders C., Vignali M., Beasley M. B., Flores R., Gnjatic S., Pe'er D., Rahman A., Amit I. & Merad M., et al. Cell | 2017 [All authors] »

Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

Genomic Characterization of Murine Monocytes Reveals C/EBP beta Transcription Factor Dependence of Ly6C(-) Cells

Read more about

Publication category: Development

, Open in new window

Authors: Mildner A. Schoenheit J., Giladi A., David E., Lara Astiaso A. D., Lorenzo Vivas V. E., Paul F., Chappell-Maor L., Priller J., Leutz A., Amit I. & Jung S., et al. Immunity | 2017 [All authors] »

Genomic Characterization of Murine Monocytes Reveals C/EBP beta Transcription Factor Dependence of Ly6C(-) Cells

Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

Read more about

Publication category: Cancer Immunotherapy

, Open in new window

Authors: Fiziev P. Akdemir K. C., Miller J. P., Keung E. Z., Samant N. S., Sharma S., Natale C. A., Terranova C. J., Maitituoheti M., Amin S. B., Martinez-Ledesma E., Dhamdhere M., Axelrad J. B., Shah A., Cheng C. S., Mahadeshwar H., Seth S., Barton M. C., Protopopov A., Tsai K. Y., Davies M. A., Garcia B. A., Amit I., Chin L., Ernst J. & Rai K., et al. Cell Reports | 2017 [All authors] »

Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

Single-cell transcriptome conservation in cryopreserved cells and tissues

Read more about

Publication category: Technology

, Open in new window

Authors: Guillaumet-Adkins A. Rodriguez-Esteban G., Mereu E., Mendez-Lago M., Jaitin D. A., Villanueva A., Vidal A., Martinez-Marti A., Felip E., Vivancos A., Keren-Shaul H., Heath S., Gut M., Amit I., Gut I. & Heyn H., et al. GENOME BIOLOGY | 2017 [All authors] »

Single-cell transcriptome conservation in cryopreserved cells and tissues

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation

Read more about

Publication category: Development

, Open in new window

Authors: Lim A. I. Li Y., Lopez-Lastra S., Stadhouders R., Paul F., Casrouge A., Serafini N., Puel A., Bustamante J., Surace L., Masse-Ranson G., David E., Strick-Marchand H., Le Bourhis B. L., Cocchi R., Topazio D., Graziano P., Muscarella L. A., Rogge L., Norel X., Sallenave J., Allez M., Graf T., Hendriks R. W., Casanova J., Amit I., Yssel H. & Di Santo S. J. P., et al. Cell | 2017 [All authors] »

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

Read more about

Publication category: Metabolism , Technology

, Open in new window

Authors: Halpern K. B., Shenhav R. Matcovitch-Natan O., Toth B., Lemze D., Golan M., Massasa E. E., Baydatch S., Landen S., Moor A. E., Brandis A., Giladi A., Stokar-Avihail A., David E., Amit I. & Itzkovitz S., et al. Nature | 2017 [All authors] »

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

Transcriptional programs that control expression of the autoimmune regulator gene Aire

Read more about

Publication category: Development

, Open in new window

Authors: Herzig Y. Nevo S., Bornstein C., Brezis M. R., Ben-Hur S., Shkedy A., Eisenberg-Bord M., Levi B., Delacher M., Goldfarb Y., David E., Weinberger L., Viukov S., Ben-Dor S., Giraud M., Hanna J. H., Breiling A., Lyko F., Amit I., Feuerer M. & Abramson J., et al. Nature Immunology | 2017 [All authors] »

Transcriptional programs that control expression of the autoimmune regulator gene Aire

High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency

Read more about

Publication category: Development

, Open in new window

Authors: Zviran A. Mor N., Rais Y., Gingold H., Peles S., Chomsky E., Viukov S., Buenrostro J. D., Weinberger L., Manor Y. S., Krupalnik V., Zerbib M., Hezroni H., Jaitin D. A., Larastiaso D., Gilad S., Benjamin S., Mousa A., Ayyash M., Sheban D., Bayerl J., Aguilera Castrejon A., Massarwa R., Maza I., Hanna S., Amit I., Stelzer Y., Ulitsky I., Greenleaf W. J., Pilpel Y., Novershtern N. & Hanna J. H., et al. BioRxiv | 2017 [All authors] »

High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency

CD74 is a novel transcription regulator

Read more about

Publication category: Development

, Open in new window

Authors: Gil-Yarom N. Radomir L., Sever L., Kramer M. P., Lewinsky H., Bornstein C., Blecher-Gonen R., Barnett Itzhaki Z., Mirkin V., Friedlander G., Shvidel L., Herishanu Y., Lolis E. J., Becker Herman S., Amit I. & Shachar I., et al. Proceedings of the National Academy of Sciences of the United States of America | 2017 [All authors] »

CD74 is a novel transcription regulator

Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

Read more about

Publication category: Development

, Open in new window

Authors: Yona S. David E., Kim K., Goldmann T., Amit I., Heikenwalder M., Nedospasov S., Prinz M., Friedman N. & Jung S., et al. Journal of Experimental Medicine | 2017 [All authors] »

Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

2016

Microbiota Diumal Rhythmicity Programs Host Transcriptome Oscillations

Read more about

Publication category: Metabolism

, Open in new window

Authors: Thaiss C., Levy M. Korem T., Dohnalova L., Shapiro H., Jaitin D., David E., Winter D., Gury-BenAri M., Tatirovsky E., Tuganbaev T., Federici S., Zmora N., Zeevi D., Dori-Bachash M., Pevsner-Fischer M., Kartvelishvily E., Brandis A., Harmelin A., Shibolet O., Halpern Z., Honda K., Amit I., Segal E. & Elinav E., et al. Cell | 2016 [All authors] »

Microbiota Diumal Rhythmicity Programs Host Transcriptome Oscillations

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

Read more about

Publication category: Technology

, Open in new window

Authors: Jaitin D. A., Weiner A., Yofe I. Lara Astiaso D., Keren-Shaul H., David E., Salame T. M., Tanay A., van Oudenaarden A. & Amit I., et al. Cell | 2016 [All authors] »

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

Extracellular Matrix Proteolysis by MT1-MMP Contributes to InfluenzaInfluenza-Related Tissue Damage and Mortality

Read more about

Publication category: Development

, Open in new window

Authors: Talmi-Frank D. Altboum Z., Solomonov I., Ziv T., Amit I. & Sagi I., et al. Cell Host & Microbe | 2016 [All authors] »

Extracellular Matrix Proteolysis by MT1-MMP Contributes to InfluenzaInfluenza-Related Tissue Damage and Mortality

Distinct biological events generated by ECM proteolysis by two homologous collagenases

Read more about

Publication category: Development

, Open in new window

Authors: Solomonov I. Zehorai E., Talmi-Frank D., Wolf S. G., Shainskaya A., Zhuravlev A., Kartvelishvily E., Visse R., Levin Y., Kampf N., Jaitin D. A., David E., Amit I., Nagase H. & Sagi I., et al. Proceedings of the National Academy of Sciences of the United States of America | 2016 [All authors] »

Distinct biological events generated by ECM proteolysis by two homologous collagenases

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome.

Read more about

Publication category: Metabolism

, Open in new window

Authors: Gury-BenAri M., Thaiss C. A. Serafini N., Winter D. R., Giladi A., Lara Astiaso A. D., Levy M., Salame T. M., Weiner A., David E., Shapiro H., Dori-Bachash M., Pevsner-Fischer M., Lorenzo Vivas V. E., Keren-Shaul H., Paul F., Harmelin A., Eberl G., Itzkovitz S., Tanay A., Di Santo S. J. P., Elinav E. & Amit I., et al. Cell | 2016 [All authors] »

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome.

Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution.

Read more about

Publication category: Technology

, Open in new window

Authors: Weiner A., Lara Astiaso A. D. Krupalnik V., Gafni O., David E., Winter D. R., Hanna J. H. & Amit I., et al. Nature Biotechnology | 2016 [All authors] »

Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution.

M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration

Read more about

Publication category: Development

, Open in new window

Authors: Barzilai S., Blecher-Gonen R. Barnett Itzhaki I. Z., Zauberman A., Lebel-Haziv Y., Amit I. & Alon R., et al. Journal of Leukocyte Biology | 2016 [All authors] »

M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration

Microglia development follows a stepwise program to regulate brain homeostasis.

Read more about

Publication category: Development , Brain

, Open in new window

Authors: Matcovitch-Natan O., Winter D. R. Giladi A., Vargas Aguilar A. S., Spinrad A., Sarrazin S., Ben-Yehuda H., David E., Zelada Gonzalez G. F., Perrin P., Keren-Shaul H., Gury M., Lara-Astaiso D., Thaiss C. A., Cohen M., Bahar Halpern H. K., Baruch K., Deczkowska A., Lorenzo Vivas V. E., Itzkovitz S., Elinav E., Sieweke M. H., Schwartz M. & Amit I., et al. Science (New York, N.Y.) | 2016 [All authors] »

Microglia development follows a stepwise program to regulate brain homeostasis.

Voices Of Biotech

Read more about

Publication category: Technology

, Open in new window

Authors: Amit I. Baker D., Barker R., Berger B., Bertozzi C., Bhatia S., Biffi A., Demichelis F., Doudna J., Dowdy S. F., Endy D., Helmstaedter M., Junca H., June C., Kamb S., Khvorova A., Kim D., Kim J., Krishnan Y., Lakadamyali M., Lappalainen T., Lewin S., Liao J., Loman N., Lundberg E., Lynd L., Martin C., Mellman I., Miyawaki A., Mummery C., Nelson K., Paz J., Peralta-Yahya P., Picotti P., Polyak K., Prather K., Qin J., Quake S., Regev A., Rogers J. A., Shetty R., Sommer M., Stevens M., Stolovitzky G., Takahashi M., Tang F., Teichmann S., Torres-Padilla M., Tripathi L., Vemula P., Verdine G., Vollmer F., Wang J., Ying J. Y., Zhang F. & Zhang T., et al. Nature Biotechnology | 2016 [All authors] »

Voices Of Biotech

Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

Read more about

Publication category: Technology

, Open in new window

Authors: Decque A. Joffre O., Magalhaes J. G., Cossec J., Blecher-Gonen R., Lapaquette P., Silvin' A., Mane N., Joubert P. -., Seeler J., Albert M. L., Amit I., Amigorena S. & Dejean A., et al. Nature Immunology | 2016 [All authors] »

Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

Read more about

Publication category: Brain

, Open in new window

Authors: Baruch K. Deczkowska A., Rosenzweig N., Tsitsou-Kampeli A., Sharif A. M., Matcovitch-Natan O., Kertser A., David E., Amit I. & Schwartz M., et al. Nature Medicine | 2016 [All authors] »

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

Read more about

Publication category: Development

, Open in new window

Authors: Amit I., Winter D. R. & Jung S. Nature Immunology | 2016 [All authors] »

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

2015

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

Read more about

Publication category: Metabolism

, Open in new window

Authors: Levy M., Thaiss C. A. Zeevi D., Dohnalova L., Zilberman-Schapira G., Mahdi J. A., David E., Savidor A., Korem T., Herzig Y., Pevsner-Fischer M., Shapiro H., Christ A., Harmelin A., Halpern Z., Latz E., Flavell R. A., Amit I., Segal E. & Elinav E., et al. Cell | 2015 [All authors] »

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

Read more about

Publication category: Development , Technology

, Open in new window

Authors: Paul F. Arkin Y., Giladi A., Jaitin D. A., Kenigsberg E., Keren-Shaul H., Winter D., Lara-Astiaso D., Gury M., Weiner A., David E., Cohen N., Lauridsen F. K. B., Haas S., Schlitzer A., Mildner A., Ginhoux F., Jung S., Trumpp A., Porse B. T., Tanay A. & Amit I., et al. Cell | 2015 [All authors] »

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

From mass cytometry to cancer prognosis

Read more about

Publication category: Cancer Immunotherapy , Technology

, Open in new window

Authors: Winter D. R., Ledergor G. & Amit I. Nature Biotechnology | 2015 [All authors] »

From mass cytometry to cancer prognosis

Making the case for chromatin profiling: a new tool to investigate the immune-regulatory landscape

Read more about

Publication category: Development , Technology

, Open in new window

Authors: Winter D. R., Jung S. & Amit I. Nature Reviews Immunology | 2015 [All authors] »

Making the case for chromatin profiling: a new tool to investigate the immune-regulatory landscape

Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes

Read more about

Publication category: Development

, Open in new window

Authors: Capucha T., Mizraji G., Segev H. Blecher-Gonen R., Winter D., Khalaileh A., Tabib Y., Attal T., Nassar M., Zelentsova K., Kisos H., Zenke M., Sere K., Hieronymus T., Burstyn-Cohen T., Amit I., Wilensky A. & Hovav A., et al. Immunity | 2015 [All authors] »

Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes

DCs are ready to commit

Read more about

Publication category: Development

, Open in new window

Authors: Winter D. & Amit I. Nature Immunology | 2015 [All authors] »

DCs are ready to commit

Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq

Read more about

Publication category: Technology

, Open in new window

Authors: Fuchs G. Voichek Y., Rabani M., Benjamin S., Gilad S., Amit I. & Oren M., et al. Nature Protocols | 2015 [All authors] »

Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq

Derivation of novel human ground state naive pluripotent stem cells (vol 504, pg 282, 2013)

Read more about

Publication category: Development

, Open in new window

Authors: Gafni O., Weinberger L., Mansour A. A. Manor Y. S., Chomsky E., Ben-Yosef D., Kalma Y., Viukov S., Maza I., Zviran A., Rais Y., Shipony Z., Mukamel Z., Krupalnik V., Zerbib M., Geula S., Caspi I., Schneir D., Shwartz T., Gilad S., Amann-Zalcenstein D., Benjamin S., Amit I., Tanay A., Massarwa R., Novershtern N. & Hanna J. H., et al. Nature | 2015 [All authors] »

Derivation of novel human ground state naive pluripotent stem cells (vol 504, pg 282, 2013)

Deterministic direct reprogramming of somatic cells to pluripotency (vol 502, pg 65, 2013)

Read more about

Publication category: Development

, Open in new window

Authors: Rais Y., Zviran A., Geula S. Gafni O., Chomsky E., Viukov S., Mansour A. A., Caspi I., Krupalnik V., Zerbib M., Maza I., Mor N., Baran D., Weinberger L., Jaitin D. A., Lara-Astiaso D., Blecher-Gonen R., Shipony Z., Mukamel Z., Hagai T., Gilad S., Amann-Zalcenstein D., Tanay A., Amit I., Novershtern N. & Hanna J. H., et al. Nature | 2015 [All authors] »

Deterministic direct reprogramming of somatic cells to pluripotency (vol 502, pg 65, 2013)

High-Resolution Chromatin Dynamics during a Yeast Stress Response

Read more about

Publication category: Technology

, Open in new window

Authors: Weiner A., Hsieh T. S., Appleboim A. Chen H. V., Rahat A., Amit I., Rando O. J. & Friedman N., et al. Molecular Cell | 2015 [All authors] »

High-Resolution Chromatin Dynamics during a Yeast Stress Response

Transcription factor binding dynamics during human ES cell differentiation

Read more about

Publication category: Development

, Open in new window

Authors: Tsankov A. M. Gu H., Akopian V., Ziller M. J., Donaghey J., Amit I., Gnirke A. & Meissner A., et al. Nature | 2015 [All authors] »

Transcription factor binding dynamics during human ES cell differentiation

m(6)A mRNA methylation facilitates resolution of naive pluripotency toward differentiation

Read more about

Publication category: Development , Technology

, Open in new window

Authors: Geula S., Moshitch-Moshkovitz S., Dominissini D. Mansour A. A., Kol N., Salmon-Divon M., Hershkovitz V., Peer E., Mor N., Manor Y. S., Ben-Haim M., Eyal E., Yunger S., Pinto Y., Jaitin D. A., Viukov S., Rais Y., Krupalnik V., Chomsky E., Zerbib M., Maza I., Rechavi Y., Massarwa R., Hanna S., Amit I., Levanon E. Y., Amariglio N., Stern-Ginossar N., Novershtern N., Rechavi G. & Hanna J. H., et al. Science | 2015 [All authors] »

m(6)A mRNA methylation facilitates resolution of naive pluripotency toward differentiation

Each cell counts: Hematopoiesis and immunity research in the era of single cell genomics

Read more about

Publication category: Technology

, Open in new window

Authors: Jaitin D. A., Keren-Shaul H., Elefant N. & Amit I. Seminars in Immunology | 2015 [All authors] »

Each cell counts: Hematopoiesis and immunity research in the era of single cell genomics

2014

A Negative Feedback Loop of Transcription Factors Specifies Alternative Dendritic Cell Chromatin States

Read more about

Publication category: Development

, Open in new window

Authors: Bornstein C., Winter D. Barnett Itzhaki I. Z., David E., Kadri S., Garber M. & Amit I., et al. Molecular Cell | 2014 [All authors] »

A Negative Feedback Loop of Transcription Factors Specifies Alternative Dendritic Cell Chromatin States

Chronic exposure to TGF beta 1 regulates myeloid cell inflammatory response in an IRF7-dependent manner

Read more about

Publication category: Development , Brain

, Open in new window

Authors: Cohen M., Matcovitch O. David E., Barnett Itzhaki I. Z., Keren-Shaul H., Blecher-Gonen R., Jaitin D. A., Sica A., Amit I. & Schwartz M., et al. EMBO Journal | 2014 [All authors] »

Chronic exposure to TGF beta 1 regulates myeloid cell inflammatory response in an IRF7-dependent manner

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

Read more about

Publication category: Development

, Open in new window

Authors: Lavin Y., Winter D. Blecher-Gonen R., David E., Keren-Shaul H., Merad M., Jung S. & Amit I., et al. Cell | 2014 [All authors] »

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies

Read more about

Publication category: Technology

, Open in new window

Authors: Rabani M. Raychowdhury R., Jovanovic M., Rooney M., Stumpo D. J., Pauli A., Hacohen N., Schier A. F., Blackshear P. J., Friedman N., Amit I. & Regev A., et al. Cell | 2014 [All authors] »

High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies

Sequential Feedback Induction Stabilizes the Phosphate Starvation Response in Budding Yeast

Read more about

Publication category: Technology

, Open in new window

Authors: Vardi N. Levy S., Gurvich Y., Polacheck T., Carmi M., Jaitin D., Amit I. & Barkai N., et al. Cell Reports | 2014 [All authors] »

Sequential Feedback Induction Stabilizes the Phosphate Starvation Response in Budding Yeast

Plasticity in the transcriptional and epigenetic circuits regulating dendritic cell lineage specification and function

Read more about

Publication category: Development

, Open in new window

Authors: Paul F. & Amit I. Current Opinion in Immunology | 2014 [All authors] »

Plasticity in the transcriptional and epigenetic circuits regulating dendritic cell lineage specification and function

Aging-induced immunological signature of the brain's choroid plexus negatively regulates neurogenesis and cognitive function

Read more about

Publication category: Brain

, Open in new window

Authors: Deczkowska A., Baruch K. David E., Castellano J. M., Miller O., Kertser A., Berkutzki T., Barnett Itzhaki I. Z., Bezalel D., Wyss-coray T., Amit I. & Schwartz M., et al. Journal of Neuroimmunology | 2014 [All authors] »

Aging-induced immunological signature of the brain's choroid plexus negatively regulates neurogenesis and cognitive function

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

Read more about

Publication category: Brain

, Open in new window

Authors: Baruch K., Deczkowska A. David E., Castellano J. M., Miller O., Kertser A., Berkutzki T., Barnett Itzhaki I. Z., Bezalel D., Wyss-Coray T., Amit I. & Schwartz M., et al. Science | 2014 [All authors] »

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

The central nervous system microenvironment imprints microglial inability to switch from pro- to anti-inflammatory phenotype

Read more about

Publication category: Brain

, Open in new window

Authors: Orit Matcovitch; Merav Cohen; Eyal David; Zohar Barnettitzhaki; Hadas Keren-Shaul; Ronnie Blecher-gonen; Diego Adhemar Jaitin; Antonio Sica; Ido Amit; Michal Schwartz Journal of Neuroimmunology | 2014 [All authors] »

The central nervous system microenvironment imprints microglial inability to switch from pro- to anti-inflammatory phenotype

The role of chromatin dynamics in immune cell development

Read more about

Publication category: Development

, Open in new window

Authors: Winter D. R. & Amit I. Immunological Reviews | 2014 [All authors] »

The role of chromatin dynamics in immune cell development

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators

Read more about

Publication category: Development

, Open in new window

Authors: Raza S. Barnett M. W., Barnett Itzhaki I. Z., Amit I., Hume D. A. & Freeman T. C., et al. Journal of Leukocyte Biology | 2014 [All authors] »

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators

Chromatin state dynamics during blood formation

Read more about

Publication category: Development , Technology

, Open in new window

Authors: Lara Astiaso A. D., Weiner A. Lorenzo Vivas V. E., Zaretsky I., Jaitin D. A., David E., Keren-Shaul H., Mildner A., Winter D., Jung S., Friedman N. & Amit I., et al. Science | 2014 [All authors] »

Chromatin state dynamics during blood formation

Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types

Read more about

Publication category: Technology

, Open in new window

Authors: Jaitin D. A., Kenigsberg E., Keren-Shaul H. Elefant N., Paul F., Zaretsky I., Mildner A., Cohen N., Jung S., Tanay A. & Amit I., et al. Science | 2014 [All authors] »

Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types

Digital cell quantification identifies global immune cell dynamics during influenza infection

Read more about

Publication category: Development , Technology

, Open in new window

Authors: Altboum Z., Steuerman Y. David E., Barnett Itzhaki I. Z., Valadarsky L., Keren-Shaul H., Meningher T., Mendelson E., Mandelboim M., Gat-Viks I. & Amit I., et al. Molecular Systems Biology | 2014 [All authors] »

Digital cell quantification identifies global immune cell dynamics during influenza infection

4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells

Read more about

Publication category: Technology

, Open in new window

Authors: Fuchs G., Voichek Y. Benjamin S., Gilad S., Amit I. & Oren M., et al. GENOME BIOLOGY | 2014 [All authors] »

4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells

2013

Derivation of novel human ground state naive pluripotent stem cells

Read more about

Publication category: Development

, Open in new window

Authors: Gafni O., Weinberger L., Mansour A. A. Manor Y. S., Chomsky E., Ben-Yosef D., Kalma Y., Viukov S., Maza I., Zviran A., Rais Y., Shipony Z., Mukamel Z., Krupalnik V., Zerbib M., Geula S., Caspi I., Schneir D., Shwartz T., Gilad S., Amann Zalcenstein D., Benjamin S., Amit I., Tanay A., Massarwa R., Novershtern N. & Hanna J. (., et al. Nature | 2013 [All authors] »

Derivation of novel human ground state naive pluripotent stem cells

Deterministic direct reprogramming of somatic cells to pluripotency

Read more about

Publication category: Development

, Open in new window

Authors: Rais Y., Zviran A., Geula S. Gafni O., Chomsky E., Viukov S., Mansour A. A., Caspi I., Krupalnik V., Zerbib M., Maza I., Mor N., Baran D., Weinberger L., Jaitin D. A., Lara Astiaso A. D., Blecher-Gonen R., Shipony Z., Mukamel Z., Hagai T., Gilad S., Amann Zalcenstein D., Tanay A., Amit I., Novershtern N. & Hanna J. (., et al. Nature | 2013 [All authors] »

Deterministic direct reprogramming of somatic cells to pluripotency

Semiconductor-based DNA sequencing of histone modification states

Read more about

Publication category: Technology

, Open in new window

Authors: Cheng C. S. Rai K., Garber M., Hollinger A., Robbins D., Anderson S., Macbeth A., Tzou A., Carneiro M. O., Raychowdhury R., Russ C., Hacohen N., Gershenwald J. E., Lennon N., Nusbaum C., Chin L., Regev A. & Amit I., et al. Nature Communications | 2013 [All authors] »

Semiconductor-based DNA sequencing of histone modification states

Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli

Read more about

Publication category: Technology

, Open in new window

Authors: Gat-Viks I. Chevrier N., Wilentzik R., Eisenhaure T., Raychowdhury R., Steuerman Y., Shalek A. K., Hacohen N., Amit I. & Regev A., et al. Nature Biotechnology | 2013 [All authors] »

Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli

High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states

Read more about

Publication category: Technology

, Open in new window

Authors: Blecher-Gonen R. Barnett Itzhaki I. Z., Jaitin D., Amann Zalcenstein Z. D., Lara Astiaso A. D. & Amit I., et al. Nature Protocols | 2013 [All authors] »

High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis

Read more about

Publication category: Development

, Open in new window

Authors: Mildner A. Chapnik E., Manor O., Yona S., Kim K., Aychek T., Varol D., Beck G., Itzhaki Z. B., Feldmesser E., Amit I., Hornstein E. & Jung S., et al. Blood | 2013 [All authors] »

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis

2012

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

Read more about

Publication category: Development

, Open in new window

Authors: Mansour A. A. Gafni O., Weinberger L., Zviran A., Ayyash M., Rais Y., Krupalnik V., Zerbib M., Amann Zalcenstein Z. D., Maza I., Geula S., Viukov S., Holtzman L., Pribluda A., Canaani E., Horn-Saban S., Amit I., Novershtern N. & Hanna J. H., et al. Nature | 2012 [All authors] »

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

Expression Noise and Acetylation Profiles Distinguish HDAC Functions

Read more about

Publication category: Technology

, Open in new window

Authors: Weinberger L., Voichek Y. Tirosh I., Hornung G., Amit I. & Barkai N., et al. Molecular Cell | 2012 [All authors] »

Expression Noise and Acetylation Profiles Distinguish HDAC Functions

EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF

Read more about

Publication category: Development

, Open in new window

Authors: Tarcic G. Avraham R., Pines G., Amit I., Shay T., Lu Y., Zwang Y., Katz M., Ben Chetrit C. N., Jacob-Hirsch J., Virgilio L., Rechavi G., Mavrothalassitis G., Mills G. B., Domany E. & Yarden Y., et al. FASEB Journal | 2012 [All authors] »

EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF

M(odu)LLating the Innate Response

Read more about

Publication category: Technology

, Open in new window

Authors: Blecher-Gonen R. & Amit I. Immunity | 2012 [All authors] »

M(odu)LLating the Innate Response

2011

Strategies to discover regulatory circuits of the mammalian immune system

Read more about

Publication category: Technology

, Open in new window

Authors: Amit I., Regev A. & Hacohen N. Nature Reviews Immunology | 2011 [All authors] »

Strategies to discover regulatory circuits of the mammalian immune system

2010

EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors

Read more about

Publication category: Development

, Open in new window

Authors: Avraham R. Sas-Chen A., Manor O., Steinfeld I., Shalgi R., Tarcic G., Bossel N., Zeisel A., Amit I., Zwang Y., Enerly E., Russnes H. G., Biagioni F., Mottolese M., Strano S., Blandino G., Borresen-Dale A., Pilpel Y. & Yakhini Z., et al. Science Signaling | 2010 [All authors] »

EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors

2007

Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy

Read more about

Publication category: Development

, Open in new window

Authors: Amit I., Wides R. & Yarden Y. Molecular Systems Biology | 2007 [All authors] »

Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy

Systems approach to growth factor signaling and to therapeutic intervention

Read more about

Publication category: Development

, Open in new window

Authors: Yarden Y. & Amit I. Ejc Supplements | 2007 [All authors] »

Systems approach to growth factor signaling and to therapeutic intervention

A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration

Read more about

Publication category: Development

, Open in new window

Authors: Katz M. Amit I., Citri A., Shay T., Carvalho S., Lavi S., Milanezi F., Lyass L., Amariglio N., Jacob-Hirsch J., Ben Chetrit C. N., Tarcic G., Lindzen M., Avraham R., Liao Y., Trusk P., Lyass A., Rechavi G. & Spector N. L., et al. Nature Cell Biology | 2007 [All authors] »

A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration

Regulation of MAPKs by growth factors and receptor tyrosine kinases

Read more about

Publication category: Development

, Open in new window

Authors: Katz M., Amit I. & Yarden Y. Biochimica Et Biophysica Acta-Molecular Cell Research | 2007 [All authors] »

Regulation of MAPKs by growth factors and receptor tyrosine kinases

A module of negative feedback regulators defines growth factor signaling

Read more about

Publication category: Development

, Open in new window

Authors: Amit I. Citri A., Shay T., Lu Y., Katz M., Zhang F., Tarcic G., Siwak D., Lahad J., Jacob-Hirsch J., Amariglio N., Vaisman N., Segal E., Rechavi G., Alon U., Mills G. B., Domany E. & Yarden Y., et al. Nature Genetics | 2007 [All authors] »

A module of negative feedback regulators defines growth factor signaling

2005

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling

Read more about

Publication category: Development

, Open in new window

Authors: Kario E. Marmor M., Adamsky K., Citri A., Amit I., Amariglio N., Rechavi G. & Yarden Y., et al. Journal of Biological Chemistry | 2005 [All authors] »

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling

2004

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

Read more about

Publication category: Development

, Open in new window

Authors: Gur G. Rubin C., Katz M., Amit I., Citri A., Nilsson J., Amariglio N., Henriksson R., Rechavi G., Hedman H., Wides R. & Yarden Y., et al. EMBO Journal | 2004 [All authors] »

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding

Read more about

Publication category: Development

, Open in new window

Authors: Amit I. Yakir L., Katz M., Zwang Y., Marmor M., Citri A., Shtiegman K., Alroy I., Tuvia S., Reiss Y., Roubini E., Cohen M., Wides R., Bacharach E., Schubert U. & Yarden Y., et al. GENES & DEVELOPMENT | 2004 [All authors] »

Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding