Publications

All years

2019

Cell composition analysis of bulk genomics using single-cell data

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Publication category: Technology

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Authors: Amit Frishberg Naama Peshes-Yaloz, Ofir Cohn, Diana Rosentul, Yael Steuerman, Liran Valadarsky, Gal Yankovitz, Michal Mandelboim, Fuad A. Iraqi, Ido Amit, Lior Mayo, Eran Bacharach, Irit Gat-Viks, et al. Nature Methods | 2019 [All authors] »

Cell composition analysis of bulk genomics using single-cell data

DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node

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Publication category: Development

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Authors: Caterina Curato Biana Bernshtein, Eva Zupancic, Almut Dufner, Diego Jaitin, Amir Giladi, Eyal David, Louise Chappell-Maor, Dena Leshkowitz, Klaus-Peter Knobeloch, Ido Amit, Helena F. Florindo, Steffen Jung, et al. Frontiers in Immunology | 2019 [All authors] »

DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node

Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity

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Publication category: Development , Technology

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Authors: Ronnie Blecher-Gonen, Pierre Bost, Kerry L. Hilligan Eyal David, Tomer Meir Salame, Elsa Roussel, Lisa M. Connor, Johannes U. Mayer, Keren Bahar Halpern, Beata Toth, Shalev Itzkovitz, Benno Schwikowski, Franca Ronchese, Ido Amit, et al. Cell Systems | 2019 [All authors] »

Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

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Publication category: Cancer Immunotherapy

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Authors: Hanjie Li, Anne M. van der Leun, Ido Yofe, Yaniv Lubling Dikla Gelbard-Solodkin, Alexander C. J. van Akkooi, Marlous van den Braber, Elisa A. Rozeman, John B. A. G. Haanen, Christian U. Blank, Hugo M. Horlings, Eyal David, Yael Baran, Akhiad Bercovich, Aviezer Lifshitz, Ton N. Schumacher, Amos Tanay, Ido Amit, et al. Cell | 2019 [All authors] »

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

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Publication category: Development

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Authors: Asaf Zviran Nofar Mor, Yoach Rais, Hila Gingold, Shani Peles, Elad Chomsky, Sergey Viukov, Jason D. Buenrostro, Roberta Scognamiglio, Leehee Weinberger, Yair S. Manor, Vladislav Krupalnik, Mirie Zerbib, Hadas Hezroni, Diego Adhemar Jaitin, David Larastiaso, Shlomit Gilad, Sima Benjamin, Ohad Gafni, Awni Mousa, Muneef Ayyash, Daoud Sheban, Jonathan Bayerl, Alejandro Aguilera-Castrejon, Rada Massarwa, Itay Maza, Suhair Hanna, Yonatan Stelzer, Igor Ulitsky, William J. Greenleaf, Amos Tanay, Andreas Trumpp, Ido Amit, Yitzhak Pilpel, Noa Novershtern, Jacob H. Hanna, et al. Cell Stem Cell | 2019 [All authors] »

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

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Publication category: Brain

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Authors: Neta Rosenzweig, Raz Dvir-Szternfeld Afroditi Tsitsou-Kampeli, Hadas Keren-Shaul, Hila Ben-Yehuda, Pierre Weill-Raynal, Liora Cahalon, Alex Kertser, Kuti Baruch, Ido Amit, Assaf Weiner, Michal Schwartz, et al. Nature Communications | 2019 [All authors] »

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

2018

Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

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Publication category: Cancer Immunotherapy

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Authors: Guy Ledergor, Assaf Weiner Mor Zada, Shuang-Yin Wang, Yael C. Cohen, Moshe E. Gatt, Nimrod Snir, Hila Magen, Maya Koren-Michowitz, Katrin Herzog-Tzarfati, Hadas Keren-Shaul, Chamutal Bornstein, Ron Rotkopf, Ido Yofe, Eyal David, Venkata Yellapantula, Sigalit Kay, Moshe Salai, Dina Ben Yehuda, Arnon Nagler, Lev Shvidel, Avi Orr-Urtreger, Keren Bahar Halpern, Shalev Itzkovitz, Ola Landgren, Jesus San-Miguel, Bruno Paiva, Jonathan J. Keats, Elli Papaemmanuil, Irit Avivi, Gabriel I. Barbash, Amos Tanay, Ido Amit, et al. Nature Medicine | 2018 [All authors] »

Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

Impaired immune surveillance accelerates accumulation of senescent cells and aging

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Publication category: Metabolism

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Authors: Yossi Ovadya, Tomer Landsberger Hanna Leins, Ezra Vadai, Hilah Gal, Anat Biran, Reut Yosef, Adi Sagiv, Amit Agrawal, Alon Shapira, Joseph Windheim, Michael Tsoory, Reinhold Schirmbeck, Ido Amit, Hartmut Geiger, Valery Krizhanovsky, et al. Nature Communications | 2018 [All authors] »

Impaired immune surveillance accelerates accumulation of senescent cells and aging

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

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Publication category: Development

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Authors: Merav Cohen, Amir Giladi, Anna-Dorothea Gorki Dikla Galbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit, et al. Cell | 2018 [All authors] »

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

From the Human Cell Atlas to dynamic immune maps in human disease

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Publication category: Technology

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Authors: Lorenz Adlung, Ido Amit Nature Reviews Immunology | 2018 [All authors] »

From the Human Cell Atlas to dynamic immune maps in human disease

Combining Developmental and Perturbation-Seq Uncovers Transcriptional Modules Orchestrating Neuronal Remodeling

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Publication category: Development

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Authors: Idan Alyagor, Victoria Berkun Hadas Keren-Shaul, Neta Marmor-Kollet, Eyal David, Oded Mayseless, Noa Issman-Zecharya, Ido Amit, Oren Schuldiner, et al. Developmental Cell | 2018 [All authors] »

Combining Developmental and Perturbation-Seq Uncovers Transcriptional Modules Orchestrating Neuronal Remodeling

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

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Publication category: Metabolism , Technology

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Authors: Keren Bahar Halpern Rom Shenhav, Hassan Massalha, Beata Toth, Adi Egozi, Efi E. Massasa, Chiara Medgalia, Eyal David, Amir Giladi, Andreas E. Moor, Ziv Porat, Ido Amit, Shalev Itzkovitz, et al. Nature Biotechnology | 2018 [All authors] »

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

Early metazoan cell type diversity and the evolution of multicellular gene regulation

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Publication category: Development

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Authors: Arnau Sebe-Pedros Elad Chomsky, Kevin Pang, David Lara-Astiaso, Federico Gaiti, Zohar Mukamel, Ido Amit, Andreas Hejnol, Bernard M. Degnan, Amos Tanay, et al. Nature ecology & evolution | 2018 [All authors] »

Early metazoan cell type diversity and the evolution of multicellular gene regulation

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

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Publication category: Development

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Authors: Amir Giladi, Franziska Paul Yoni Herzog, Yaniv Lubling, Assaf Weiner, Ido Yofe, Diego Jaitin, Nina Cabezas-Wallscheid, Regine Dress, Florent Ginhoux, Andreas Trumpp, Amos Tanay, Ido Amit, et al. Nature Cell Biology | 2018 [All authors] »

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

The bone marrow is patrolled by NK cells that are primed and expand in response to systemic viral activation

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Publication category: Development

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Authors: Idan Milo Ronnie Blecher-Gonen, Zohar Barnett-Itzhaki, Raz Bar-Ziv, Orna Tal, Irina Gurevich, Tali Feferman, Ingo Drexler, Ido Amit, Philippe Bousso, Guy Shakhar, et al. European Journal of Immunology | 2018 [All authors] »

The bone marrow is patrolled by NK cells that are primed and expand in response to systemic viral activation

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

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Publication category: Development

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Authors: Chamutal Bornstein, Shir Nevo, Amir Giladi Noam Kadouri, Marie Pouzolles, Francois Gerbe, Eyal David, Alice Machado, Anna Chuprin, Beata Toth, Ori Goldberg, Shalev Itzkovitz, Naomi Taylor, Philippe Jay, Valerie S. Zimmermann, Jakub Abramson, Ido Amit, et al. Nature | 2018 [All authors] »

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing

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Publication category: Technology

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Authors: Yael Steuerman, Merav Cohen Naama Peshes-Yaloz, Liran Valadarsky, Ofir Cohn, Eyal David, Amit Frishberg, Lior Mayo, Eran Bacharach, Ido Amit, Irit Gat-Viks, et al. Cell Systems | 2018 [All authors] »

Dissection of Influenza Infection In Vivo by Single-Cell RNA Sequencing

Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies

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Publication category: Development

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Authors: Moriya Gamliel Debra Goldman-Wohl, Batya Isaacson, Chamutal Gur, Natan Stein, Rachel Yamin, Michael Berger, Myriam Grunewald, Eli Keshet, Yoach Rais, Chamutal Bornstein, Eyal David, Adam Jelinski, Iris Eisenberg, Caryn Greenfield, Arbel Ben-David, Tal Imbar, Ronit Gilad, Ronit Haimov-Kochman, David Mankuta, Matan Elami-Suzin, Ido Amit, Jacob H. Hanna, Simcha Yagel, Ofer Mandelboim, et al. Immunity | 2018 [All authors] »

Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

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Publication category: Brain

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Authors: Aleksandra Deczkowska, Hadas Keren-Shaul, Assaf Weiner Marco Colonna, Michal Schwartz, Ido Amit, et al. Cell | 2018 [All authors] »

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Microglial immune checkpoint mechanisms

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Publication category: Brain

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Authors: Aleksandra Deczkowska, Ido Amit, Michal Schwartz Nature Neuroscience | 2018 [All authors] »

Microglial immune checkpoint mechanisms

Salient experiences are represented by unique transcriptional signatures in the mouse brain

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Publication category: Brain

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Authors: Diptendu Mukherjee Bogna Marta Ignatowska-Jankowska, Eyal Itskovits, Ben Jerry Gonzales, Hagit Turm, Liz Izakson, Doron Haritan, Noa Bleistein, Chen Cohen, Ido Amit, Tal Shay, Brad Grueter, Alon Zaslaver, Ami Citri, et al. eLife | 2018 [All authors] »

Salient experiences are represented by unique transcriptional signatures in the mouse brain

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

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Publication category: Development , Brain

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Authors: Morgane Sonia Thion Donovan Low, Aymeric Silvin, Jinmiao Chen, Pauline Grisel, Jonas Schulte-Schrepping, Ronnie Blecher, Thomas Ulas, Paola Squarzoni, Guillaume Hoeffel, Fanny Coulpier, Eleni Siopi, Friederike Sophie David, Claus Scholz, Foo Shihui, Josephine Lum, Arlaine Anne Amoyo, Anis Larbi, Michael Poidinger, Anne Buttgereit, Pierre Marie Lledo, Melanie Greter, Jerry Kok Yen Chan, Ido Amit, Marc Beyer, Joachim Ludwig Schultze, Andreas Schlitzer, Sven Pettersson, Florent Ginhoux, Sonia Garel, et al. Cell | 2018 [All authors] »

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

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Publication category: Technology

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Authors: Amir Giladi, Ido Amit Cell | 2018 [All authors] »

Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

2017

Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq

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Publication category: Technology

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Authors: Chiara Medaglia, Amir Giladi, Liat Stoler-Barak Marco De Giovanni, Tomer Meir Salame, Adi Biram, Eyal David, Hanjie Li, Matteo Iannacone, Ziv Shulman, Ido Amit, et al. Science | 2017 [All authors] »

Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

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Publication category: Brain

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Authors: Aleksandra Deczkowska, Orit Matcovitch-Natan Afroditi Tsitsou-Kampeli, Sefi Ben-Hamo, Raz Dvir-Szternfeld, Amit Spinrad, Oded Singer, Eyal David, Deborah R. Winter, Lucas K. Smith, Alexander Kertser, Kuti Baruch, Neta Rosenzweig, Anna Terem, Marco Prinz, Saul Villeda, Ami Citri, Ido Amit, Michal Schwartz, et al. Nature Communications | 2017 [All authors] »

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

MicroRNA-142 controls thymocyte proliferation

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Publication category: Development , Autoimmunity

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Authors: Alexander Mildner Elik Chapnik, Diana Varol, Tegest Aychek, Nardi Lampl, Natalia Rivkin, Anita Bringmann, Franziska Paul, Sigalit Boura-Halfon, Yifat Segal Hayoun, Itzhaki, Zohar Barnett Itzhaki, Ido Amit, Eran Hornstein, Steffen Jung, et al. European Journal of Immunology | 2017 [All authors] »

MicroRNA-142 controls thymocyte proliferation

Immunology, one cell at a time

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Publication category: Technology

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Authors: Amir Giladi, Ido Amit Nature | 2017 [All authors] »

Immunology, one cell at a time

Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

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Publication category: Development , Brain

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Authors: Diana Varol Alexander Mildner, Thomas Blank, Anat Shemer, Neta Barashi, Simon Yona, Eyal David, Sigalit Boura-Halfon, Yifat Segal-Hayoun, Louise Chappell-Maor, Hadas Keren-Shaul, Dena Leshkowitz, Eran Hornstein, Martin Fuhrmann, Ido Amit, Nicola Maggio, Marco Prinz, Steffen Jung, et al. Immunity | 2017 [All authors] »

Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

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Publication category: Brain

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Authors: Hadas Keren-Shaul, Amit Spinrad, Assaf Weiner, Orit Matcovitch-Natan Raz Dvir-Szternfeld, Tyler K. Ulland, Eyal David, Kuti Baruch, David Lara-Astaiso, Beata Toth, Shalev Itzkovitz, Marco Colonna, Michal Schwartz, Ido Amit, et al. Cell | 2017 [All authors] »

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

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Publication category: Cancer Immunotherapy

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Authors: Yonit Lavin Soma Kobayashi, Andrew Leader, El-ad David Amir, Naama Elefant, Camille Bigenwald, Romain Remark, Robert Sweeney, Christian D. Becker, Jacob H. Levine, Klaus Meinhof, Andrew Chow, Seunghee Kim-Shulze, Andrea Wolf, Chiara Medaglia, Hanjie Li, Julie A. Rytlewski, Ryan O. Emerson, Alexander Solovyov, Benjamin D. Greenbaum, Catherine Sanders, Marissa Vignali, Mary Beth Beasley, Raja Flores, Sacha Gnjatic, Dana Pe'er, Adeeb Rahman, Ido Amit, Miriam Merad, et al. Cell | 2017 [All authors] »

Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

Genomic Characterization of Murine Monocytes Reveals C/EBP beta Transcription Factor Dependence of Ly6C(-) Cells

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Publication category: Development

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Authors: Alexander Mildner Joerg Schoenheit, Amir Giladi, Eyal David, Astiaso, David Lara Astiaso, Vivas, Erika Lorenzo Vivas, Franziska Paul, Louise Chappell-Maor, Josef Priller, Achim Leutz, Ido Amit, Steffen Jung, et al. Immunity | 2017 [All authors] »

Genomic Characterization of Murine Monocytes Reveals C/EBP beta Transcription Factor Dependence of Ly6C(-) Cells

Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

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Publication category: Cancer Immunotherapy

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Authors: Petko Fiziev Kadir C. Akdemir, John P. Miller, Emily Z. Keung, Neha S. Samant, Sneha Sharma, Christopher A. Natale, Christopher J. Terranova, Mayinuer Maitituoheti, Samirkumar B. Amin, Emmanuel Martinez-Ledesma, Mayura Dhamdhere, Jacob B. Axelrad, Amiksha Shah, Christine S. Cheng, Harshad Mahadeshwar, Sahil Seth, Michelle C. Barton, Alexei Protopopov, Kenneth Y. Tsai, Michael A. Davies, Benjamin A. Garcia, Ido Amit, Lynda Chin, Jason Ernst, Kunal Rai, et al. Cell Reports | 2017 [All authors] »

Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression

Single-cell transcriptome conservation in cryopreserved cells and tissues

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Publication category: Technology

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Authors: Amy Guillaumet-Adkins Gustavo Rodriguez-Esteban, Elisabetta Mereu, Maria Mendez-Lago, Diego A. Jaitin, Alberto Villanueva, August Vidal, Alex Martinez-Marti, Enriqueta Felip, Ana Vivancos, Hadas Keren-Shaul, Simon Heath, Marta Gut, Ido Amit, Ivo Gut, Holger Heyn, et al. GENOME BIOLOGY | 2017 [All authors] »

Single-cell transcriptome conservation in cryopreserved cells and tissues

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation

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Publication category: Development

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Authors: Ai Ing Lim Yan Li, Silvia Lopez-Lastra, Ralph Stadhouders, Franziska Paul, Armanda Casrouge, Nicolas Serafini, Anne Puel, Jacinta Bustamante, Laura Surace, Guillemette Masse-Ranson, Eyal David, Helene Strick-Marchand, Bourhis, Lionel Le Bourhis, Roberto Cocchi, Davide Topazio, Paolo Graziano, Lucia Anna Muscarella, Lars Rogge, Xavier Norel, Jean-Michel Sallenave, Matthieu Allez, Thomas Graf, Rudi W. Hendriks, Jean-Laurent Casanova, Ido Amit, Hans Yssel, Santo, James P. Di Santo, et al. Cell | 2017 [All authors] »

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

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Publication category: Metabolism , Technology

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Authors: Keren Bahar Halpern, Rom Shenhav Orit Matcovitch-Natan, Beata Toth, Doron Lemze, Matan Golan, Efi E. Massasa, Shaked Baydatch, Shanie Landen, Andreas E. Moor, Alexander Brandis, Amir Giladi, Avigail Stokar-Avihail, Eyal David, Ido Amit, Shalev Itzkovitz, et al. Nature | 2017 [All authors] »

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

Transcriptional programs that control expression of the autoimmune regulator gene Aire

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Publication category: Development

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Authors: Yonatan Herzig Shir Nevo, Chamutal Bornstein, Miriam R. Brezis, Sharon Ben-Hur, Aya Shkedy, Michal Eisenberg-Bord, Ben Levi, Michael Delacher, Yael Goldfarb, Eyal David, Leehee Weinberger, Sergey Viukov, Shifra Ben-Dor, Matthieu Giraud, Jacob H. Hanna, Achim Breiling, Frank Lyko, Ido Amit, Markus Feuerer, Jakub Abramson, et al. Nature Immunology | 2017 [All authors] »

Transcriptional programs that control expression of the autoimmune regulator gene Aire

High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency

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Publication category: Development

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Authors: Asaf Zviran Nofar Mor, Yoach Rais, Hila Gingold, Shani Peles, Elad Chomsky, Sergey Viukov, Jason D. Buenrostro, Leehee Weinberger, Yair S. Manor, Vladislav Krupalnik, Mirie Zerbib, Hadas Hezroni, Diego Adhemar Jaitin, David Larastiaso, Shlomit Gilad, Sima Benjamin, Awni Mousa, Muneef Ayyash, Daoud Sheban, Jonathan Bayerl, Alejandro Aguilera Castrejon, Rada Massarwa, Itay Maza, Suhair Hanna, Ido Amit, Yonatan Stelzer, Igor Ulitsky, William J. Greenleaf, Yitzhak Pilpel, Noa Novershtern, Jacob H. Hanna, et al. BioRxiv | 2017 [All authors] »

High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency

CD74 is a novel transcription regulator

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Publication category: Development

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Authors: Naama Gil-Yarom Lihi Radomir, Lital Sever, Matthias P. Kramer, Hadas Lewinsky, Chamutal Bornstein, Ronnie Blecher-Gonen, Zohar Barnett Itzhaki, Vita Mirkin, Gilgi Friedlander, Lev Shvidel, Yair Herishanu, Elias J. Lolis, Shirly Becker Herman, Ido Amit, Idit Shachar, et al. Proceedings of the National Academy of Sciences of the United States of America | 2017 [All authors] »

CD74 is a novel transcription regulator

Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

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Publication category: Development

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Authors: Simon Yona Eyal David, Ki-Wook Kim, Tobias Goldmann, Ido Amit, Mathias Heikenwalder, Sergei Nedospasov, Marco Prinz, Nir Friedman, Steffen Jung, et al. Journal of Experimental Medicine | 2017 [All authors] »

Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

2016

Microbiota Diumal Rhythmicity Programs Host Transcriptome Oscillations

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Publication category: Metabolism

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Authors: CA Thaiss, Maayan Levy Tal Korem, L Dohnalova, Hagit Shapiro, DA Jaitin, Eyal David, DR Winter, M Gury-BenAri, Evgeny Tatirovsky, Timur Tuganbaev, S Federici, Niv Zmora, Danny Zeevi, M Dori-Bachash, Meirav Pevsner-Fischer, Elena Kartvelishvily, Alexander Brandis, Alon Harmelin, O Shibolet, Z Halpern, K Honda, Ido Amit, Eran Segal, Eran Elinav, et al. Cell | 2016 [All authors] »

Microbiota Diumal Rhythmicity Programs Host Transcriptome Oscillations

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

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Publication category: Technology

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Authors: Diego Adhemar Jaitin, Assaf Weiner, Ido Yofe David Lara Astiaso, Hadas Keren-Shaul, Eyal David, Tomer Meir Salame, Amos Tanay, Alexander van Oudenaarden, Ido Amit, et al. Cell | 2016 [All authors] »

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

Extracellular Matrix Proteolysis by MT1-MMP Contributes to InfluenzaInfluenza-Related Tissue Damage and Mortality

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Publication category: Development

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Authors: Dalit Talmi-Frank Zeev Altboum, Inna Solomonov, Tamar Ziv, Ido Amit, Irit Sagi, et al. Cell Host & Microbe | 2016 [All authors] »

Extracellular Matrix Proteolysis by MT1-MMP Contributes to InfluenzaInfluenza-Related Tissue Damage and Mortality

Distinct biological events generated by ECM proteolysis by two homologous collagenases

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Publication category: Development

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Authors: Inna Solomonov Eldar Zehorai, Dalit Talmi-Frank, Sharon G. Wolf, Alla Shainskaya, Alina Zhuravlev, Elena Kartvelishvily, Robert Visse, Yishai Levin, Nir Kampf, Diego Adhemar Jaitin, Eyal David, Ido Amit, Hideaki Nagase, Irit Sagi, et al. Proceedings of the National Academy of Sciences of the United States of America | 2016 [All authors] »

Distinct biological events generated by ECM proteolysis by two homologous collagenases

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome.

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Publication category: Metabolism

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Authors: Meital Gury-BenAri, Christoph Alexander Thaiss Nicolas Serafini, Deborah R Winter, Amir Giladi, Astiaso, David Lara Astiaso, Maayan Levy, Tomer Meir Salame, Assaf Weiner, Eyal David, Hagit Shapiro, Mally Dori-Bachash, Meirav Pevsner-Fischer, Vivas, Erika Lorenzo Vivas, Hadas Keren-Shaul, Franziska Paul, Alon Harmelin, Gerard Eberl, Shalev Itzkovitz, Amos Tanay, Santo, James P Di Santo, Eran Elinav, Ido Amit, et al. Cell | 2016 [All authors] »

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome.

Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution.

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Publication category: Technology

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Authors: Assaf Weiner, Astiaso, David Lara Astiaso Vladislav Krupalnik, Ohad Gafni, Eyal David, Deborah R Winter, Jacob H Hanna, Ido Amit, et al. Nature Biotechnology | 2016 [All authors] »

Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution.

M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration

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Publication category: Development

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Authors: Sagi Barzilai, Ronnie Blecher-Gonen Itzhaki, Zohar Barnett Itzhaki, Ayelet Zauberman, Yaeli Lebel-Haziv, Ido Amit, Ronen Alon, et al. Journal of Leukocyte Biology | 2016 [All authors] »

M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration

Microglia development follows a stepwise program to regulate brain homeostasis.

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Publication category: Development , Brain

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Authors: Orit Matcovitch-Natan, Deborah R Winter Amir Giladi, Aguilar, Stephanie Vargas Aguilar, Amit Spinrad, Sandrine Sarrazin, Hila Ben-Yehuda, Eyal David, Gonzalez, Fabiola Zelada Gonzalez, Pierre Perrin, Hadas Keren-Shaul, Meital Gury, David Lara-Astaiso, Christoph Alexander Thaiss, Merav Cohen, Halpern, Keren Bahar Halpern, Kuti Baruch, Aleksandra Deczkowska, Vivas, Erika Lorenzo Vivas, Shalev Itzkovitz, Eran Elinav, Michael H Sieweke, Michal Schwartz, Ido Amit, et al. Science (New York, N.Y.) | 2016 [All authors] »

Microglia development follows a stepwise program to regulate brain homeostasis.

Voices Of Biotech

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Publication category: Technology

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Authors: Ido Amit David Baker, Roger Barker, Bonnie Berger, Carolyn Bertozzi, Sangeeta Bhatia, Alessandra Biffi, Francesca Demichelis, Jennifer Doudna, Steven F. Dowdy, Drew Endy, Moritz Helmstaedter, Howard Junca, Carl June, Sasha Kamb, Anastasia Khvorova, Dae-Hyeong Kim, Jin-Soo Kim, Yamuna Krishnan, Melike Lakadamyali, Tuuli Lappalainen, Sharon Lewin, James Liao, Nick Loman, Emma Lundberg, Lee Lynd, Cathie Martin, Ira Mellman, Atsushi Miyawaki, Christine Mummery, Karen Nelson, Jeanne Paz, Pamela Peralta-Yahya, Paola Picotti, Kornelia Polyak, Kristala Prather, Jun Qin, Stephen Quake, Aviv Regev, John A. Rogers, Reshma Shetty, Morten Sommer, Molly Stevens, Gustavo Stolovitzky, Masayo Takahashi, Fuchou Tang, Sarah Teichmann, Maria-Elena Torres-Padilla, Leena Tripathi, Praveen Vemula, Greg Verdine, Frank Vollmer, Jun Wang, Jackie Y. Ying, Feng Zhang, Tian Zhang, et al. Nature Biotechnology | 2016 [All authors] »

Voices Of Biotech

Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

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Publication category: Technology

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Authors: Adrien Decque Olivier Joffre, Joao G. Magalhaes, Jack-Christophe Cossec, Ronnie Blecher-Gonen, Pierre Lapaquette, Aymeric Silvin', Nicolas Mane, Pierre -Emmanuel Joubert, Jacob-Sebastian Seeler, Matthew L. Albert, Ido Amit, Sebastian Amigorena, Anne Dejean, et al. Nature Immunology | 2016 [All authors] »

Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

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Publication category: Brain

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Authors: Kuti Baruch Aleksandra Deczkowska, Neta Rosenzweig, Afroditi Tsitsou-Kampeli, Alaa Mohammad Sharif, Orit Matcovitch-Natan, Alexander Kertser, Eyal David, Ido Amit, Michal Schwartz, et al. Nature Medicine | 2016 [All authors] »

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

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Publication category: Development

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Authors: Ido Amit, Deborah R. Winter, Steffen Jung Nature Immunology | 2016 [All authors] »

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

2015

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

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Publication category: Development , Technology

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Authors: Franziska Paul Ya'ara Arkin, Amir Giladi, Diego Adhemar Jaitin, Ephraim Kenigsberg, Hadas Keren-Shaul, Deborah Winter, David Lara-Astiaso, Meital Gury, Assaf Weiner, Eyal David, Nadav Cohen, Felicia Kathrine Bratt Lauridsen, Simon Haas, Andreas Schlitzer, Alexander Mildner, Florent Ginhoux, Steffen Jung, Andreas Trumpp, Bo Torben Porse, Amos Tanay, Ido Amit, et al. Cell | 2015 [All authors] »

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

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Publication category: Metabolism

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Authors: Maayan Levy, Christoph Alexander Thaiss David Zeevi, Lenka Dohnalova, Gili Zilberman-Schapira, Jemal Ali Mahdi, Eyal David, Alon Savidor, Tal Korem, Yonatan Herzig, Meirav Pevsner-Fischer, Hagit Shapiro, Anette Christ, Alon Harmelin, Zamir Halpern, Eicke Latz, Richard A Flavell, Ido Amit, Eran Segal, Eran Elinav, et al. Cell | 2015 [All authors] »

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

Making the case for chromatin profiling: a new tool to investigate the immune-regulatory landscape

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Publication category: Development , Technology

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Authors: Deborah R. Winter, Steffen Jung, Ido Amit Nature Reviews Immunology | 2015 [All authors] »

Making the case for chromatin profiling: a new tool to investigate the immune-regulatory landscape

From mass cytometry to cancer prognosis

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Publication category: Cancer Immunotherapy , Technology

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Authors: Deborah R. Winter, Guy Ledergor, Ido Amit Nature Biotechnology | 2015 [All authors] »

From mass cytometry to cancer prognosis

Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes

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Publication category: Development

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Authors: Tal Capucha, Gabriel Mizraji, Hadas Segev Ronnie Blecher-Gonen, Deborah Winter, Abed Khalaileh, Yaara Tabib, Tsipora Attal, Maria Nassar, Katya Zelentsova, Hen Kisos, Martin Zenke, Kristin Sere, Thomas Hieronymus, Tal Burstyn-Cohen, Ido Amit, Asaf Wilensky, Avi-Hai Hovav, et al. Immunity | 2015 [All authors] »

Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes

DCs are ready to commit

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Publication category: Development

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Authors: DR Winter, Ido Amit Nature Immunology | 2015 [All authors] »

DCs are ready to commit

High-Resolution Chromatin Dynamics during a Yeast Stress Response

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Publication category: Technology

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Authors: Assaf Weiner, Tsung-Han S. Hsieh, Alon Appleboim Hsiuyi V. Chen, Ayelet Rahat, Ido Amit, Oliver J. Rando, Nir Friedman, et al. Molecular Cell | 2015 [All authors] »

High-Resolution Chromatin Dynamics during a Yeast Stress Response

Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq

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Publication category: Technology

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Authors: Gilad Fuchs Yoav Voichek, Michal Rabani, Sima Benjamin, Shlomit Gilad, Ido Amit, Moshe Oren, et al. Nature Protocols | 2015 [All authors] »

Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq

Derivation of novel human ground state naive pluripotent stem cells (vol 504, pg 282, 2013)

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Publication category: Development

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Authors: Ohad Gafni, Leehee Weinberger, Abed AlFatah Mansour Yair S. Manor, Elad Chomsky, Dalit Ben-Yosef, Yael Kalma, Sergey Viukov, Itay Maza, Asaf Zviran, Yoach Rais, Zohar Shipony, Zohar Mukamel, Vladislav Krupalnik, Mirie Zerbib, Shay Geula, Inbal Caspi, Dan Schneir, Tamar Shwartz, Shlomit Gilad, Daniela Amann-Zalcenstein, Sima Benjamin, Ido Amit, Amos Tanay, Rada Massarwa, Noa Novershtern, Jacob H. Hanna, et al. Nature | 2015 [All authors] »

Derivation of novel human ground state naive pluripotent stem cells (vol 504, pg 282, 2013)

Deterministic direct reprogramming of somatic cells to pluripotency (vol 502, pg 65, 2013)

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Publication category: Development

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Authors: Yoach Rais, Asaf Zviran, Shay Geula Ohad Gafni, Elad Chomsky, Sergey Viukov, Abed AlFatah Mansour, Inbal Caspi, Vladislav Krupalnik, Mirie Zerbib, Itay Maza, Nofar Mor, Dror Baran, Leehee Weinberger, Diego A. Jaitin, David Lara-Astiaso, Ronnie Blecher-Gonen, Zohar Shipony, Zohar Mukamel, Tzachi Hagai, Shlomit Gilad, Daniela Amann-Zalcenstein, Amos Tanay, Ido Amit, Noa Novershtern, Jacob H. Hanna, et al. Nature | 2015 [All authors] »

Deterministic direct reprogramming of somatic cells to pluripotency (vol 502, pg 65, 2013)

m(6)A mRNA methylation facilitates resolution of naive pluripotency toward differentiation

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Publication category: Development , Technology

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Authors: Shay Geula, Sharon Moshitch-Moshkovitz, Dan Dominissini Abed AlFatah Mansour, Nitzan Kol, Mali Salmon-Divon, Vera Hershkovitz, Eyal Peer, Nofar Mor, Yair S. Manor, Moshe-Shay Ben-Haim, Eran Eyal, Sharon Yunger, Yishay Pinto, Diego Adhemar Jaitin, Sergey Viukov, Yoach Rais, Vladislav Krupalnik, Elad Chomsky, Mirie Zerbib, Itay Maza, Yoav Rechavi, Rada Massarwa, Suhair Hanna, Ido Amit, Erez Y. Levanon, Ninette Amariglio, Noam Stern-Ginossar, Noa Novershtern, Gideon Rechavi, Jacob H. Hanna, et al. Science | 2015 [All authors] »

m(6)A mRNA methylation facilitates resolution of naive pluripotency toward differentiation

Each cell counts: Hematopoiesis and immunity research in the era of single cell genomics

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Publication category: Technology

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Authors: Diego Adhemar Jaitin, Hadas Keren-Shaul, Naama Elefant, Ido Amit Seminars in Immunology | 2015 [All authors] »

Each cell counts: Hematopoiesis and immunity research in the era of single cell genomics

Transcription factor binding dynamics during human ES cell differentiation

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Publication category: Development

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Authors: Alexander M. Tsankov Hongcang Gu, Veronika Akopian, Michael J. Ziller, Julie Donaghey, Ido Amit, Andreas Gnirke, Alexander Meissner, et al. Nature | 2015 [All authors] »

Transcription factor binding dynamics during human ES cell differentiation

2014

High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies

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Publication category: Technology

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Authors: Michal Rabani Raktima Raychowdhury, Marko Jovanovic, Michael Rooney, Deborah J. Stumpo, Andrea Pauli, Nir Hacohen, Alexander F. Schier, Perry J. Blackshear, Nir Friedman, Ido Amit, Aviv Regev, et al. Cell | 2014 [All authors] »

High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies

A Negative Feedback Loop of Transcription Factors Specifies Alternative Dendritic Cell Chromatin States

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Publication category: Development

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Authors: Chamutal Bornstein, Deborah Winter Itzhaki, Zohar Barnett Itzhaki, Eyal David, Sabah Kadri, Manuel Garber, Ido Amit, et al. Molecular Cell | 2014 [All authors] »

A Negative Feedback Loop of Transcription Factors Specifies Alternative Dendritic Cell Chromatin States

Chronic exposure to TGF beta 1 regulates myeloid cell inflammatory response in an IRF7-dependent manner

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Publication category: Development , Brain

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Authors: Merav Cohen, Orit Matcovitch Eyal David, Itzhaki, Zohar Barnett Itzhaki, Hadas Keren-Shaul, Ronnie Blecher-Gonen, Diego Adhemar Jaitin, Antonio Sica, Ido Amit, Michal Schwartz, et al. EMBO Journal | 2014 [All authors] »

Chronic exposure to TGF beta 1 regulates myeloid cell inflammatory response in an IRF7-dependent manner

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

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Publication category: Development

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Authors: Yonit Lavin, Deborah Winter Ronnie Blecher-Gonen, Eyal David, Hadas Keren-Shaul, Miriam Merad, Steffen Jung, Ido Amit, et al. Cell | 2014 [All authors] »

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

Sequential Feedback Induction Stabilizes the Phosphate Starvation Response in Budding Yeast

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Publication category: Technology

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Authors: Noam Vardi Sagi Levy, Yonat Gurvich, Tamar Polacheck, Miri Carmi, Diego Jaitin, Ido Amit, Naama Barkai, et al. Cell Reports | 2014 [All authors] »

Sequential Feedback Induction Stabilizes the Phosphate Starvation Response in Budding Yeast

Plasticity in the transcriptional and epigenetic circuits regulating dendritic cell lineage specification and function

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Publication category: Development

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Authors: Franziska Paul, Ido Amit Current Opinion in Immunology | 2014 [All authors] »

Plasticity in the transcriptional and epigenetic circuits regulating dendritic cell lineage specification and function

Aging-induced immunological signature of the brain's choroid plexus negatively regulates neurogenesis and cognitive function

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Publication category: Brain

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Authors: Aleksandra Deczkowska, Kuti Baruch Eyal David, Joseph M. Castellano, Omer Miller, Alexander Kertser, Tamara Berkutzki, Itzhaki, Zohar Barnett Itzhaki, Dana Bezalel, Tony Wyss-coray, Ido Amit, Michal Schwartz, et al. Journal of Neuroimmunology | 2014 [All authors] »

Aging-induced immunological signature of the brain's choroid plexus negatively regulates neurogenesis and cognitive function

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

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Publication category: Brain

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Authors: Kuti Baruch, Aleksandra Deczkowska Eyal David, Joseph M. Castellano, Omer Miller, Alexander Kertser, Tamara Berkutzki, Itzhaki, Zohar Barnett Itzhaki, Dana Bezalel, Tony Wyss-Coray, Ido Amit, Michal Schwartz, et al. Science | 2014 [All authors] »

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

The central nervous system microenvironment imprints microglial inability to switch from pro- to anti-inflammatory phenotype

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Publication category: Brain

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Authors: Orit Matcovitch, Merav Cohen Eyal David, Zohar Barnettitzhaki, Hadas Keren-Shaul, Ronnie Blecher-gonen, Diego Adhemar Jaitin, Antonio Sica, Ido Amit, Michal Schwartz, et al. Journal of Neuroimmunology | 2014 [All authors] »

The central nervous system microenvironment imprints microglial inability to switch from pro- to anti-inflammatory phenotype

The role of chromatin dynamics in immune cell development

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Publication category: Development

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Authors: Deborah R. Winter, Ido Amit Immunological Reviews | 2014 [All authors] »

The role of chromatin dynamics in immune cell development

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators

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Publication category: Development

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Authors: Sobia Raza Mark W. Barnett, Itzhaki, Zohar Barnett Itzhaki, Ido Amit, David A. Hume, Tom C. Freeman, et al. Journal of Leukocyte Biology | 2014 [All authors] »

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators

Chromatin state dynamics during blood formation

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Publication category: Development , Technology

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Authors: Astiaso, David Lara Astiaso, Assaf Weiner Vivas, Erika Lorenzo Vivas, Irina Zaretsky, Diego Adhemar Jaitin, Eyal David, Hadas Keren-Shaul, Alexander Mildner, Deborah Winter, Steffen Jung, Nir Friedman, Ido Amit, et al. Science | 2014 [All authors] »

Chromatin state dynamics during blood formation

Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types

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Publication category: Technology

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Authors: Diego Adhemar Jaitin, Ephraim Kenigsberg, Hadas Keren-Shaul Naama Elefant, Franziska Paul, Irina Zaretsky, Alexander Mildner, Nadav Cohen, Steffen Jung, Amos Tanay, Ido Amit, et al. Science | 2014 [All authors] »

Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types

Digital cell quantification identifies global immune cell dynamics during influenza infection

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Publication category: Development , Technology

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Authors: Zeev Altboum, Y Steuerman Eyal David, Itzhaki, Zohar Barnett Itzhaki, Liran Valadarsky, Hadas Keren-Shaul, T Meningher, E Mendelson, M Mandelboim, I Gat-Viks, Ido Amit, et al. Molecular Systems Biology | 2014 [All authors] »

Digital cell quantification identifies global immune cell dynamics during influenza infection

4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells

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Publication category: Technology

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Authors: Gilad Fuchs, Yoav Voichek Sima Benjamin, Shlomit Gilad, Ido Amit, Moshe Oren, et al. GENOME BIOLOGY | 2014 [All authors] »

4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells

2013

Derivation of novel human ground state naive pluripotent stem cells

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Publication category: Development

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Authors: Ohad Gafni, Leehee Weinberger, Abed AlFatah Mansour Yair S. Manor, Elad Chomsky, Dalit Ben-Yosef, Yael Kalma, Sergey Viukov, Itay Maza, Asaf Zviran, Yoach Rais, Zohar Shipony, Zohar Mukamel, Vladislav Krupalnik, Mirie Zerbib, Shay Geula, Inbal Caspi, Dan Schneir, Tamar Shwartz, Shlomit Gilad, Daniela Amann Zalcenstein, Sima Benjamin, Ido Amit, Amos Tanay, Rada Massarwa, Noa Novershtern, Jacob (Yaqub) Hanna, et al. Nature | 2013 [All authors] »

Derivation of novel human ground state naive pluripotent stem cells

Semiconductor-based DNA sequencing of histone modification states

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Publication category: Technology

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Authors: Christine S. Cheng Kunal Rai, Manuel Garber, Andrew Hollinger, Dana Robbins, Scott Anderson, Alyssa Macbeth, Austin Tzou, Mauricio O. Carneiro, Raktima Raychowdhury, Carsten Russ, Nir Hacohen, Jeffrey E. Gershenwald, Niall Lennon, Chad Nusbaum, Lynda Chin, Aviv Regev, Ido Amit, et al. Nature Communications | 2013 [All authors] »

Semiconductor-based DNA sequencing of histone modification states

Deterministic direct reprogramming of somatic cells to pluripotency

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Publication category: Development

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Authors: Yoach Rais, Asaf Zviran, Shay Geula Ohad Gafni, Elad Chomsky, Sergey Viukov, Abed AlFatah Mansour, Inbal Caspi, Vladislav Krupalnik, Mirie Zerbib, Itay Maza, Nofar Mor, Dror Baran, Leehee Weinberger, Diego A. Jaitin, Astiaso, David Lara Astiaso, Ronnie Blecher-Gonen, Zohar Shipony, Zohar Mukamel, Tzachi Hagai, Shlomit Gilad, Daniela Amann Zalcenstein, Amos Tanay, Ido Amit, Noa Novershtern, Jacob (Yaqub) Hanna, et al. Nature | 2013 [All authors] »

Deterministic direct reprogramming of somatic cells to pluripotency

Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli

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Publication category: Technology

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Authors: Irit Gat-Viks Nicolas Chevrier, Roni Wilentzik, Thomas Eisenhaure, Raktima Raychowdhury, Yael Steuerman, Alex K. Shalek, Nir Hacohen, Ido Amit, Aviv Regev, et al. Nature Biotechnology | 2013 [All authors] »

Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli

High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states

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Publication category: Technology

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Authors: Ronnie Blecher-Gonen Itzhaki, Zohar Barnett Itzhaki, Diego Jaitin, Zalcenstein, Daniela Amann Zalcenstein, Astiaso, David Lara Astiaso, Ido Amit, et al. Nature Protocols | 2013 [All authors] »

High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis

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Publication category: Development

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Authors: Alexander Mildner Elik Chapnik, Ohad Manor, Simon Yona, Ki-Wook Kim, Tegest Aychek, Diana Varol, Gilad Beck, Zohar Barnett Itzhaki, Ester Feldmesser, Ido Amit, Eran Hornstein, Steffen Jung, et al. Blood | 2013 [All authors] »

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis

2012

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

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Publication category: Development

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Authors: Abed AlFatah Mansour Ohad Gafni, Leehee Weinberger, Asaf Zviran, Muneef Ayyash, Yoach Rais, Vladislav Krupalnik, Mirie Zerbib, Zalcenstein, Daniela Amann Zalcenstein, Itay Maza, Shay Geula, Sergey Viukov, Liad Holtzman, Ariel Pribluda, Eli Canaani, Shirley Horn-Saban, Ido Amit, Noa Novershtern, Jacob H. Hanna, et al. Nature | 2012 [All authors] »

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

Expression Noise and Acetylation Profiles Distinguish HDAC Functions

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Publication category: Technology

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Authors: Leehee Weinberger, Yoav Voichek Itay Tirosh, Gil Hornung, Ido Amit, Naama Barkai, et al. Molecular Cell | 2012 [All authors] »

Expression Noise and Acetylation Profiles Distinguish HDAC Functions

M(odu)LLating the Innate Response

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Publication category: Technology

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Authors: Ronnie Blecher-Gonen, Ido Amit Immunity | 2012 [All authors] »

M(odu)LLating the Innate Response

EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF

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Publication category: Development

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Authors: Gabi Tarcic Roi Avraham, Gur Pines, Ido Amit, Tal Shay, Yiling Lu, Yaara Zwang, Menachem Katz, Chetrit, Nir Ben Chetrit, Jasmine Jacob-Hirsch, Laura Virgilio, Gideon Rechavi, George Mavrothalassitis, Gordon B. Mills, Eytan Domany, Yosef Yarden, et al. FASEB Journal | 2012 [All authors] »

EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF

2011

Strategies to discover regulatory circuits of the mammalian immune system

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Publication category: Technology

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Authors: Ido Amit, Aviv Regev, Nir Hacohen Nature Reviews Immunology | 2011 [All authors] »

Strategies to discover regulatory circuits of the mammalian immune system

2010

EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors

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Publication category: Development

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Authors: Roi Avraham Aldema Sas-Chen, Ohad Manor, Israel Steinfeld, Reut Shalgi, Gabi Tarcic, Noa Bossel, Amit Zeisel, Ido Amit, Yaara Zwang, Espen Enerly, Hege G. Russnes, Francesca Biagioni, Marcella Mottolese, Sabrina Strano, Giovanni Blandino, Anne-Lise Borresen-Dale, Yitzhak Pilpel, Zohar Yakhini, et al. Science Signaling | 2010 [All authors] »

EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors

2007

Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy

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Publication category: Development

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Authors: Ido Amit, Ron Wides, Yosef Yarden Molecular Systems Biology | 2007 [All authors] »

Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy

Systems approach to growth factor signaling and to therapeutic intervention

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Publication category: Development

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Authors: Yosef Yarden, Ido Amit Ejc Supplements | 2007 [All authors] »

Systems approach to growth factor signaling and to therapeutic intervention

A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration

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Publication category: Development

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Authors: Menachem Katz Ido Amit, Ami Citri, Tal Shay, Silvia Carvalho, Sara Lavi, Fernanda Milanezi, Ljuba Lyass, Ninette Amariglio, Jasmine Jacob-Hirsch, Chetrit, Nir Ben Chetrit, Gabi Tarcic, Moshit Lindzen, Roi Avraham, Yi-Chun Liao, Patricia Trusk, Asya Lyass, Gideon Rechavi, Neil L. Spector, et al. Nature Cell Biology | 2007 [All authors] »

A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration

Regulation of MAPKs by growth factors and receptor tyrosine kinases

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Publication category: Development

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Authors: Menachem Katz, Ido Amit, Yosef Yarden Biochimica Et Biophysica Acta-Molecular Cell Research | 2007 [All authors] »

Regulation of MAPKs by growth factors and receptor tyrosine kinases

A module of negative feedback regulators defines growth factor signaling

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Publication category: Development

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Authors: Ido Amit Ami Citri, Tal Shay, Yiling Lu, Menachem Katz, Fan Zhang, Gabi Tarcic, Doris Siwak, John Lahad, Jasmine Jacob-Hirsch, Ninette Amariglio, Nora Vaisman, Eran Segal, Gideon Rechavi, Uri Alon, Gordon B. Mills, Eytan Domany, Yosef Yarden, et al. Nature Genetics | 2007 [All authors] »

A module of negative feedback regulators defines growth factor signaling

2005

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling

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Publication category: Development

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Authors: Edith Kario MD Marmor, K Adamsky, A Citri, Ido Amit, N Amariglio, G Rechavi, Yosef Yarden, et al. Journal of Biological Chemistry | 2005 [All authors] »

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling

2004

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

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Publication category: Development

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Authors: G Gur C Rubin, M Katz, Ido Amit, A Citri, J Nilsson, N Amariglio, R Henriksson, G Rechavi, H Hedman, R Wides, Yosef Yarden, et al. EMBO Journal | 2004 [All authors] »

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding

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Publication category: Development

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Authors: Ido Amit Liat Yakir, M Katz, Yaara Zwang, MD Marmor, A Citri, K Shtiegman, I Alroy, S Tuvia, Y Reiss, E Roubini, Merav Cohen, R Wides, E Bacharach, U Schubert, Yosef Yarden, et al. GENES & DEVELOPMENT | 2004 [All authors] »

Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding