Prof. Avraham Yaron
Wiring of the nervous system during development sets the pattern of connections that allow the organism to function in the world. The proper formation of neural circuitry is orchestrated by co-occurrence of progressive events, such as axonal guidance and branching, and regressive events in which axons and neurons are eliminated. Although wiring errors underly a variety of neurodevelopmental disorders, the mechanisms that govern this complex phenomenon are largely unknown. In the Yaron lab, we are studying these mechanisms, exploring the functional and behavioral outcomes of miswiring, and examining how genetic wiring programs are modulated by experience.