Prof. Ayelet Erez
deciphering the dynamics of cellular metabolism at different disease states.
Our lab deciphers the dynamics of cellular metabolism in different disease states. In particular, we are interested in understanding the contribution of the urea cycle components to the metabolic changes accompanying disease pathogenesis. Urea cycle metabolites serve as metabolic junctions that directly contribute to distinct metabolic fluxes at different cellular states. Consequently, changes in the function of urea cycle proteins have important effects on cell growth, survival, and proliferation. Identifying specific metabolic alterations during disease can improve diagnosis, progress monitoring, and therapeutic interventions.
