| Yeast Systematic Name | Yeast Symbol | SGDID | Analog Name | Analog Description | EC | Organism | Disease | Structure | Uniprot | Human ID | Human Symbol | HHsearch Probability | HHsearch E_value | HHsearch P_value | HHsearch Score | Flag Disease related | Flag Homo sapiens | Flag Mus musculus | Flag Danio rerio | Flag Drosophila melanogaster | Flag Caenorhabditis elegans | Flag Arabidopsis thaliana | Flag Escherichia coli |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| YDL042C | SIR2 | SGDID:S000002200 | SIR2RP1 LINF_260007100 LINJ_26_0200 |
SIR2RP1 LINF_260007100 LINJ_26_0200 |
2.3.1.286 | Leishmania infantum | 5ol0_a | Q8I6E4 | 100.00 | 8.20E-44 | 7.00E-48 | 367.30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YDL042C | SIR2 | SGDID:S000002200 | cobB sir2 TM_0490 |
NAD-dependent protein deacetylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog) (Sir2Tm) |
2.3.1.286 | Thermotoga maritima | 1yc5_a | Q9WYW0 | 100.00 | 5.20E-40 | 4.70E-44 | 324.30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YDL042C | SIR2 | SGDID:S000002200 | SIR2 MAR1 YDL042C D2714 |
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2) |
2.3.1.286 | Saccharomyces cerevisiae | 2hjh_b | P06700 | 100.00 | 9.80E-58 | 8.30E-62 | 477.70 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YDL042C | SIR2 | SGDID:S000002200 | SIRT3 SIR2L3 |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3) |
2.3.1.286 | Homo sapiens | Non-Alcoholic Fatty Liver Disease,Diabetes Mellitus,Monckeberg Arteriosclerosis,Skin Amelanotic Melanoma,Optic Atrophy 1,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11,Hypertension, Essential,Mitochondrial Complex I Deficiency, Nuclear Type 1,Aging,Lung Cancer |
4bn4_a | Q9NTG7 | ENSG00000142082 | SIRT3 | 100.00 | 2.10E-41 | 1.80E-45 | 341.70 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YDL042C | SIR2 | SGDID:S000002200 | cobB1 AF_1676 |
NAD-dependent protein deacylase 1 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 1) (SIR2-Af1) |
2.3.1.286 | Archaeoglobus fulgidus | 1m2h_a | O28597 | 100.00 | 1.10E-37 | 1.00E-41 | 307.70 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YDL042C | SIR2 | SGDID:S000002200 | SIRT6 SIR2L6 |
NAD-dependent protein deacetylase sirtuin-6 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 6) (SIR2-like protein 6) |
2.3.1.286 | Homo sapiens | Lethal Brain And Heart Developmental Defects,Monckeberg Arteriosclerosis,Osteoporosis,Premature Menopause,Mood Disorder,Hutchinson-Gilford Progeria Syndrome,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus,Aging |
3zg6_a | Q8N6T7 | ENSG00000077463 | SIRT6 | 100.00 | 5.70E-39 | 4.90E-43 | 327.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YDL042C | SIR2 | SGDID:S000002200 | Sir2A Sir2 PF13_0152 |
NAD-dependent protein deacylase Sir2A (EC 2.3.1.-) (Regulatory protein SIR2 homolog A) |
2.3.1.- | Plasmodium falciparum | 3jwp_a | Q8IE47 | 100.00 | 1.50E-37 | 1.40E-41 | 309.80 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YDL042C | SIR2 | SGDID:S000002200 | sirt4 TGas015j14.1-001 |
sirt4 TGas015j14.1-001 |
2.3.1.-,2.3.1.286, | Xenopus tropicalis | 5oj7_a | Q28CB4 | 100.00 | 9.40E-37 | 8.30E-41 | 307.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YDL042C | SIR2 | SGDID:S000002200 | SIRT5 SIR2L5 |
NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5) |
2.3.1.- | Homo sapiens | Monckeberg Arteriosclerosis,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11 |
4g1c_b | Q9NXA8 | ENSG00000124523 | SIRT5 | 100.00 | 5.60E-38 | 5.10E-42 | 312.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YDL042C | SIR2 | SGDID:S000002200 | cobB2 Sir2Af2 AF_0112 |
NAD-dependent protein deacylase 2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-Af2) |
2.3.1.286 | Archaeoglobus fulgidus | 1s7g_c | O30124 | 100.00 | 1.40E-38 | 1.30E-42 | 314.10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YDL042C | SIR2 | SGDID:S000002200 | SIRT1 SIR2L1 |
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] |
2.3.1.286 | Homo sapiens | Glucose Metabolism Disease,Retinitis Pigmentosa,Non-Alcoholic Fatty Liver Disease,Overnutrition,Inherited Metabolic Disorder,Diabetes Mellitus,Non-Alcoholic Steatohepatitis,Lipid Storage Disease,Alzheimer Disease,Myocardial Infarction,Osteonecrosis Of The Jaw,Major Depressive Disorder,Stroke, Ischemic,Amyotrophic Lateral Sclerosis 1,Primary Biliary Cholangitis,Leukemia, Acute Myeloid,Periapical Periodontitis,Cataract,Optic Atrophy 1,Osteoporosis,Cockayne Syndrome,Aplastic Anemia,Burkitt Lymphoma,Breast Cancer,Colorectal Cancer,Peripheral Nervous System Disease,Age-Related Hearing Loss,Lipomatosis,Mood Disorder,Hutchinson-Gilford Progeria Syndrome,Prostate Cancer,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus,Hyperphosphatemia,Renal Fibrosis,Huntington Disease,Hypertension, Essential,Acquired Metabolic Disease,Nijmegen Breakage Syndrome,Systemic Lupus Erythematosus,Inguinal Hernia,Medulloblastoma,Aging,Progesterone Resistance |
4kxq_a | Q96EB6 | ENSG00000096717 | SIRT1 | 100.00 | 2.10E-38 | 1.80E-42 | 318.90 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YDL042C | SIR2 | SGDID:S000002200 | SIRT2 SIR2L SIR2L2 |
NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) |
2.3.1.286 | Homo sapiens | Monckeberg Arteriosclerosis,Wallerian Degeneration,Anoxia,Mood Disorder,Hutchinson-Gilford Progeria Syndrome,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus |
1j8f_a | Q8IXJ6 | 100.00 | 1.20E-53 | 9.10E-58 | 439.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| YDL042C | SIR2 | SGDID:S000002200 | SIRT2 SIR2L SIR2L2 |
NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) |
2.3.1.286 | Homo sapiens | Monckeberg Arteriosclerosis,Wallerian Degeneration,Anoxia,Mood Disorder,Hutchinson-Gilford Progeria Syndrome,Disease Of Mental Health,Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus |
4rmh_a | Q8IXJ6 | ENSG00000068903 | SIRT2 | 100.00 | 1.00E-42 | 8.90E-47 | 355.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |