







Yeast Systematic Name | Yeast Symbol | SGDID | Analog Name | Analog Description | EC | Organism | Disease | Structure | Uniprot | Human ID | Human Symbol | HHsearch Probability | HHsearch E_value | HHsearch P_value | HHsearch Score | Flag Disease related | Flag Homo sapiens | Flag Mus musculus | Flag Danio rerio | Flag Drosophila melanogaster | Flag Caenorhabditis elegans | Flag Arabidopsis thaliana | Flag Escherichia coli |
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YDL214C | PRR2 | SGDID:S000002373 | ROP8 |
ROP8 |
Toxoplasma gondii | 3byv_a | O15693 | 99.40 | 4.60E-18 | 5.20E-22 | 170.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
YDL214C | PRR2 | SGDID:S000002373 | KDR FLK1 VEGFR2 |
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) |
2.7.10.1 | Homo sapiens | Psoriasis,Pancreatic Adenocarcinoma,Corneal Neovascularization,Mesothelioma, Malignant,Skin Melanoma,Pneumothorax,Heart Disease,Neovascular Glaucoma,Endocrine Gland Cancer,Retinal Vein Occlusion,Retinal Vascular Occlusion,Vascular Cancer,Retinitis Pigmentosa,Thyroid Gland Cancer,Ovarian Hyperstimulation Syndrome,Lung Cancer Susceptibility 3,Chronic Myelomonocytic Leukemia,Bone Cancer,Microvascular Complications Of Diabetes 5,Mast-Cell Leukemia,Melanoma,Malignant Ciliary Body Melanoma,Lung Non-Squamous Non-Small Cell Carcinoma,Diabetes Mellitus,Degeneration Of Macula And Posterior Pole,Macular Retinal Edema,Clear Cell Renal Cell Carcinoma,Septate Uterus,Primary Cutaneous B-Cell Lymphoma,Myocardial Infarction,Breast Angiosarcoma,Eye Degenerative Disease,Placenta Accreta,Cavernous Hemangioma,Neuroblastoma,Pilocytic Astrocytoma,Epithelioid Hemangioendothelioma,Arteriovenous Malformations Of The Brain,Olecranon Bursitis,Pulmonary Vein Stenosis,Retinal Vascular Disease,Gastroesophageal Junction Adenocarcinoma,Leukemia, Acute Myeloid,Capillary Disease,Hematologic Cancer,Hemangioma,Radiation Proctitis,Kidney Cancer,Leukostasis,Aortic Valve Disease 1,Hemangioblastoma,Bladder Cancer,Capillary Hemangioma,Heritable Pulmonary Arterial Hypertension,Retinal Artery Occlusion,Fundus Dystrophy,Parasitic Protozoa Infectious Disease,Kaposiform Hemangioendothelioma,Nodular Goiter,Background Diabetic Retinopathy,Endometriosis,Pediculus Humanus Capitis Infestation,Vein Disease,Bursitis,Ovarian Cancer,Hemangioma, Capillary Infantile,Adenocarcinoma,Pre-Eclampsia,Eye Disease,Cervical Adenosquamous Carcinoma,Breast Carcinoma In Situ,Breast Cancer,Glioblastoma,Squamous Cell Carcinoma, Head And Neck,Rosacea,High Grade Glioma,Gliosarcoma,Colorectal Cancer,Familial Hypercholesterolemia,Hepatocellular Carcinoma,Proctitis,Premature Menopause,8p11 Myeloproliferative Syndrome,Clopidogrel Resistance,Kuhnt-Junius Degeneration,Angiokeratoma Of Mibelli,Angiokeratoma Circumscriptum,Pheochromocytoma,Rhabdomyosarcoma,Ischemia,Cerebral Cavernous Malformations,Conjunctival Vascular Disease,Macular Degeneration, Age-Related, 1,Sarcoma,Hantavirus Pulmonary Syndrome,Fibrosarcoma Of Bone,Skin Carcinoma,Gastric Cancer,Lymphangioma,Mobitz Type Ii Atrioventricular Block,Prostate Cancer,Disease Of Mental Health,Coats Disease,Microvascular Complications Of Diabetes 1,Pulmonary Hypertension,Type 2 Diabetes Mellitus,Angiosarcoma,Drug-Induced Lupus Erythematosus,Placental Insufficiency,Thyroid Gland Follicular Carcinoma,Merkel Cell Carcinoma,Thyroid Gland Medullary Carcinoma,Renal Cell Carcinoma, Papillary, 1,Esophageal Cancer,Exudative Vitreoretinopathy 1,Tetralogy Of Fallot,Myelodysplastic Syndrome,Sorsby Fundus Dystrophy,Ewing Sarcoma,Gastrointestinal Stromal Tumor,Varicose Veins,Hirschsprung Disease 1,Limb Ischemia,Bone Squamous Cell Carcinoma,Renal Cell Carcinoma, Nonpapillary,Mucosal Melanoma,Hypertension, Essential,Lipoprotein Quantitative Trait Locus,Cardiovascular Organ Benign Neoplasm,Intussusception,Moyamoya Disease 1,Premature Ovarian Failure 1,Medulloblastoma,Lung Cancer,Pancreatic Cancer |
4ase_a | P35968 | ENSG00000128052 | KDR | 99.50 | 5.70E-19 | 6.60E-23 | 173.90 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CAMK4 CAMK CAMK-GR CAMKIV |
Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) |
2.7.11.17 | Homo sapiens | Lung Large Cell Carcinoma,Alacrima, Achalasia, And Mental Retardation Syndrome,Disease Of Mental Health,Crouzon Syndrome With Acanthosis Nigricans,Systemic Lupus Erythematosus,Gingival Fibromatosis |
2w4o_a | Q16566 | ENSG00000152495 | CAMK4 | 99.50 | 3.60E-18 | 4.00E-22 | 170.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | PKMYT1 MYT1 |
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) |
2.7.11.1 | Homo sapiens | 5vcy_a | Q99640 | ENSG00000127564 | PKMYT1 | 99.50 | 2.40E-18 | 2.80E-22 | 165.60 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
YDL214C | PRR2 | SGDID:S000002373 | PAK4 KIAA1142 |
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) |
2.7.11.1 | Homo sapiens | Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease |
4xbr_a | O96013 | ENSG00000130669 | PAK4 | 99.50 | 3.30E-19 | 3.80E-23 | 178.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | MAP2K1 MEK1 PRKMK1 |
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) |
2.7.12.2 | Homo sapiens | Melorheostosis, Isolated,Skin Melanoma,Achondroplasia,Heart Disease,Ichthyosis,Squamous Cell Carcinoma,Cerebral Hemisphere Lipoma,Corpus Callosum Lipoma,Lung Cancer Susceptibility 3,Melorheostosis,Pulmonary Valve Stenosis,Suppression Of Tumorigenicity 12,Melanoma,Acneiform Dermatitis,Neurofibromatosis-Noonan Syndrome,Hypertrophic Cardiomyopathy,Osteopoikilosis,Alzheimer Disease,Rasopathy,Noonan Syndrome-Like Disorder With Loose Anagen Hair,Keratosis Pilaris Atrophicans Faciei,Costello Syndrome,Anthrax Disease,Extracranial Arteriovenous Malformation,Neurofibromatosis, Type I,Neuroblastoma,Skin Granular Cell Tumor,Pseudo-Turner Syndrome,Leukemia, Acute Myeloid,Noonan Syndrome 1,Senile Angioma,Hemangioma,Rosai-Dorfman Disease,Bladder Cancer,Mixed Cell Adenoma,Hairy Cell Leukemia,Prostate Squamous Cell Carcinoma,Noonan Syndrome-Like Disorder With Loose Anagen Hair 2,Cardiofaciocutaneous Syndrome 3,Ovarian Cancer,Myeloid Leukemia,Adenocarcinoma,Breast Cancer,Squamous Cell Carcinoma, Head And Neck,Colorectal Cancer,Pulmonary Valve Disease,Hepatocellular Carcinoma,Cardiofaciocutaneous Syndrome 1,Splenic Diffuse Red Pulp Small B-Cell Lymphoma,Pheochromocytoma,Rhabdomyosarcoma,Noonan Syndrome With Multiple Lentigines,Fibrosarcoma,Histiocytosis,Skin Carcinoma,Gastric Cancer,Arteriovenous Malformation,Prostate Cancer,Disease Of Mental Health,Gastric Adenocarcinoma,Langerhans Cell Histiocytosis,Bladder Urothelial Carcinoma,Lymphoma, Non-Hodgkin, Familial,Diamond-Blackfan Anemia 20,Acute Promyelocytic Leukemia,Ovarian Melanoma,Autism Spectrum Disorder,Kaposi Sarcoma,Cardiomyopathy, Familial Hypertrophic, 25,Medulloblastoma,Autism,Melanoma, Cutaneous Malignant 1,Melanoma, Uveal,Lung Cancer,Pancreatic Cancer |
3eqc_a | Q02750 | ENSG00000169032 | MAP2K1 | 99.40 | 5.90E-18 | 6.70E-22 | 168.20 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | MYLK4 SGK085 |
Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085) |
2.7.11.1 | Homo sapiens | Cardiomyopathy, Familial Restrictive, 2,Deafness, Autosomal Recessive 17,Deafness, Autosomal Recessive 14,Cardiomyopathy, Familial Restrictive, 3 |
2x4f_a | Q86YV6 | ENSG00000145949 | MYLK4 | 99.50 | 2.10E-18 | 2.30E-22 | 173.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CHEK1 CHK1 |
Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) |
2.7.11.1 | Homo sapiens | Tongue Carcinoma,Neuroblastoma,Leukemia, Acute Myeloid,Sporadic Breast Cancer,Cerebellar Disease,Ovarian Cancer,Breast Cancer,Colorectal Cancer,Microcephaly,Xeroderma Pigmentosum, Variant Type,Fanconi Anemia, Complementation Group A,Retinoblastoma,Esophageal Cancer,Seckel Syndrome,Mantle Cell Lymphoma,Pigmentary Disorder, Reticulate, With Systemic Manifestations, X-Linked,Ovarian Clear Cell Carcinoma,Autosomal Recessive Cerebellar Ataxia,Li-Fraumeni Syndrome,Ataxia-Telangiectasia,Medulloblastoma,Primary Autosomal Recessive Microcephaly,Lung Cancer |
2e9v_b | O14757 | ENSG00000149554 | CHEK1 | 99.50 | 2.10E-18 | 2.50E-22 | 159.80 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | ACK2 |
Casein kinase II subunit alpha (EC 2.7.11.1) (CK II) (CK2-alpha) |
2.7.11.1 | Zea mays | 4dgn_a | P28523 | 99.50 | 1.10E-18 | 1.30E-22 | 169.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | MELK KIAA0175 |
Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) |
2.7.10.2 | Homo sapiens | Colorectal Cancer |
5k00_a | Q14680 | ENSG00000165304 | MELK | 99.50 | 4.00E-18 | 4.50E-22 | 168.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | PASK KIAA0135 |
PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) |
2.7.11.1 | Homo sapiens | Niemann-Pick Disease, Type C1 |
3dls_a | Q96RG2 | ENSG00000115687 | PASK | 99.40 | 7.00E-18 | 7.90E-22 | 166.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CDKL5 STK9 |
Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) |
2.7.11.22 | Homo sapiens | Cdkl5 Deficiency Disorder,Ohtahara Syndrome,Seizure Disorder,Childhood Absence Epilepsy,Epilepsy,Gait Apraxia,Gene Duplication Disease,Nicolaides-Baraitser Syndrome,Amyotrophic Lateral Sclerosis 1,Angelman Syndrome,Focal Epilepsy,Developmental And Epileptic Encephalopathy 14,Epilepsy With Generalized Tonic-Clonic Seizures,Congenital Nervous System Abnormality,Developmental And Epileptic Encephalopathy,Fundus Dystrophy,Juvenile Retinoschisis,Bruxism,X-Linked Congenital Retinoschisis,Early Myoclonic Encephalopathy,Stxbp1 Encephalopathy,Microcephaly,Mental Retardation, Autosomal Dominant 20,Encephalopathy,Benign Neonatal Seizures,Alacrima, Achalasia, And Mental Retardation Syndrome,Benign Epilepsy With Centrotemporal Spikes,Developmental And Epileptic Encephalopathy 9,Methylmalonic Acidemia,Benign Familial Neonatal Epilepsy,West Syndrome,Disease Of Mental Health,Lubs X-Linked Mental Retardation Syndrome,Fragile X Syndrome,Pitt-Hopkins Syndrome,Mowat-Wilson Syndrome,Developmental And Epileptic Encephalopathy 2,Lennox-Gastaut Syndrome,Sturge-Weber Syndrome,Neonatal Period Electroclinical Syndrome,Infancy Electroclinical Syndrome,Childhood Electroclinical Syndrome,Early Infantile Epileptic Encephalopathy,Developmental And Epileptic Encephalopathy 4,Myasthenic Syndrome, Congenital, 11, Associated With Acetylcholine Receptor Deficiency,Encephalopathy Due To Defective Mitochondrial And Peroxisomal Fission 1,Aicardi Syndrome,Specific Developmental Disorder,Pervasive Developmental Disorder,Dravet Syndrome,Developmental And Epileptic Encephalopathy 1,Benign Familial Infantile Epilepsy,Generalized Epilepsy With Febrile Seizures Plus,Pyruvate Dehydrogenase E1-Alpha Deficiency,Retinoschisis 1, X-Linked, Juvenile,Rett Syndrome,Epilepsy, Myoclonic Juvenile,Autism,Christianson Syndrome,Epilepsy, Idiopathic Generalized,Peho Syndrome |
4bgq_a | O76039 | ENSG00000008086 | CDKL5 | 99.50 | 1.10E-18 | 1.40E-22 | 165.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CSNK2A1 CK2A1 |
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) |
2.7.11.1 | Homo sapiens | Okur-Chung Neurodevelopmental Syndrome,Connective Tissue Disease,Alzheimer Disease,Prostate Stromal Sarcoma,Distal Muscular Dystrophy With Anterior Tibial Onset,Kidney Leiomyosarcoma,Colorectal Cancer,Microcephaly,Alacrima, Achalasia, And Mental Retardation Syndrome,Prostate Cancer,Disease Of Mental Health,Malaria |
3q04_a | P68400 | ENSG00000101266 | CSNK2A1 | 99.40 | 4.50E-18 | 5.30E-22 | 164.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | TNNI3K CARK |
Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) |
2.7.11.1 | Homo sapiens | Dilated Cardiomyopathy,Restrictive Cardiomyopathy,Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy,Familial Atrial Fibrillation |
4yfi_a | Q59H18 | ENSG00000259030 | FPGT-TNNI3K | 99.40 | 7.30E-18 | 8.80E-22 | 162.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | Map3k14 Nik |
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (Serine/threonine-protein kinase NIK) |
2.7.11.25 | Mus musculus | 4g3f_a | Q9WUL6 | 99.50 | 9.80E-19 | 1.10E-22 | 171.00 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | BN1205_040370 TGVEG_207820 |
BN1205_040370 TGVEG_207820 |
2.7.11.24 | Toxoplasma gondii | 3rp9_a | B6KP12 | 99.50 | 2.50E-18 | 2.80E-22 | 176.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | RAD53 MEC2 SAD1 SPK1 YPL153C P2588 |
Serine/threonine-protein kinase RAD53 (EC 2.7.12.1) (CHEK2 homolog) (Serine-protein kinase 1) |
2.7.12.1 | Saccharomyces cerevisiae | 4pdp_a | P22216 | 99.40 | 5.30E-18 | 6.10E-22 | 167.30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | CAMK2D CAMKD |
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) |
2.7.11.17 | Homo sapiens | Dilated Cardiomyopathy,Cardiomyopathy, Dilated, 1dd |
2wel_a | Q13557 | ENSG00000145349 | CAMK2D | 99.50 | 3.70E-18 | 4.20E-22 | 166.70 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CDKL2 |
Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Protein kinase p56 KKIAMRE) (Serine/threonine-protein kinase KKIAMRE) |
2.7.11.22 | Homo sapiens | Papillary Serous Adenocarcinoma,Orofaciodigital Syndrome Vi |
4bbm_a | Q92772 | ENSG00000138769 | CDKL2 | 99.40 | 7.40E-18 | 8.30E-22 | 166.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | ROCK2 KIAA0619 |
Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) |
2.7.11.1 | Homo sapiens | Coronary Artery Vasospasm,Dextrocardia,Ureteral Obstruction,Breast Cancer,Tongue Squamous Cell Carcinoma,Hypertension, Essential |
4wot_b | O75116 | ENSG00000134318 | ROCK2 | 99.40 | 4.10E-18 | 4.60E-22 | 173.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CDK7 CAK CAK1 CDKN7 MO15 STK1 |
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) |
2.7.11.22,2.7.11.23, | Homo sapiens | Myofibrillar Myopathy,Cockayne Syndrome,Breast Cancer,Xeroderma Pigmentosum, Complementation Group D,Xeroderma Pigmentosum, Variant Type,Xeroderma Pigmentosum, Complementation Group B |
1ua2_b | P50613 | ENSG00000134058 | CDK7 | 99.50 | 1.20E-18 | 1.30E-22 | 171.20 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | rop18 ROP18 TGRH88_034260 |
rop18 ROP18 TGRH88_034260 |
Toxoplasma gondii | 4jrn_a | Q2PAY2 | 99.40 | 7.80E-18 | 8.90E-22 | 168.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
YDL214C | PRR2 | SGDID:S000002373 | Ripk4 Ankrd3 Pkk |
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-associated protein kinase) (PKC-regulated protein kinase) |
2.7.11.1 | Mus musculus | 5wnj_a | Q9ERK0 | 99.50 | 3.80E-18 | 4.40E-22 | 168.00 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | Camk1 |
Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) |
2.7.11.17 | Rattus norvegicus | 1a06_a | Q63450 | 99.80 | 1.10E-25 | 1.10E-29 | 229.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | PHKG2 |
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) |
2.7.11.19 | Homo sapiens | Glycogen Storage Disease Ixa,Glycogen Storage Disease Ixc,Glycogen Storage Disease,Phosphorylase Kinase Deficiency,Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency,Glycogen Storage Disease Ia,Glycogen Storage Disease, Type Ixd,Glycogen Storage Disease Ix,Glycogen Storage Disease Ixb |
2y7j_c | P15735 | ENSG00000156873 | PHKG2 | 99.50 | 1.40E-18 | 1.60E-22 | 172.70 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | PAK1 |
Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) |
2.7.11.1 | Homo sapiens | Thymic Neuroendocrine Tumor,Prolapse Of Urethra,Gastroesophageal Junction Adenocarcinoma,Neurofibromatosis,Breast Cancer,Colorectal Cancer,Gastric Cancer,Intellectual Developmental Disorder With Macrocephaly, Seizures, And Speech Delay,Helicobacter Pylori Infection |
5kbq_a | Q13153 | ENSG00000149269 | PAK1 | 99.40 | 4.80E-18 | 5.60E-22 | 161.30 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | TTN |
Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) |
2.7.11.1 | Homo sapiens | Muscular Disease,Heart Disease,Constrictive Pericarditis,Congenital Fiber-Type Disproportion,Mitral Valve Insufficiency,Aortic Valve Disease 2,Congenital Structural Myopathy,Myopathy,Amyloidosis,Cardiomyopathy, Dilated, 1e,Syncope,Myofibrillar Myopathy,Atrial Heart Septal Defect,Mitochondrial Dna Depletion Syndrome 12b,Childhood-Onset Progressive Contractures-Limb-Girdle Weakness-Muscle Dystrophy Syndrome,Emery-Dreifuss Muscular Dystrophy,Cortical Thymoma,Muscle Tissue Disease,Morvan'S Fibrillary Chorea,Neuromuscular Disease,Hypertrophic Cardiomyopathy,Familial Isolated Dilated Cardiomyopathy,Rasopathy,Autosomal Dominant Distal Myopathy,Lung Large Cell Carcinoma,Myopathy, Distal, 1,Myositis,Myotonic Dystrophy 1,Systolic Heart Failure,Myopathy, Myofibrillar, 1,Diastolic Heart Failure,Autosomal Recessive Limb-Girdle Muscular Dystrophy,Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2a,Muscular Dystrophy,Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2g,Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2j,Muscular Atrophy,Tibial Muscular Dystrophy,Limb-Girdle Muscular Dystrophy,Arrhythmogenic Right Ventricular Dysplasia, Familial, 1,Epithelial Malignant Thymoma,Hyaline Body Myopathy,Isolated Elevated Serum Creatine Phosphokinase Levels,Noonan Syndrome 1,Newborn Respiratory Distress Syndrome,Thymus Clear Cell Carcinoma,Reducing Body Myopathy,Myocarditis,Atrial Standstill 1,Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 10,Hereditary Proximal Myopathy With Early Respiratory Failure,Dilated Cardiomyopathy,Alcoholic Cardiomyopathy,Lmna-Related Dilated Cardiomyopathy,Thymus Gland Disease,Long Qt Syndrome,Cardiomyopathy, Dilated, 1dd,Heart Conduction Disease,Udd Distal Myopathy - Tibial Muscular Dystrophy,Muscular Dystrophy, Congenital, Lmna-Related,Neuropathy,Perinephritis,Familial Isolated Arrhythmogenic Ventricular Dysplasia, Right Dominant Form,Familial Isolated Arrhythmogenic Ventricular Dysplasia, Biventricular Form,Familial Isolated Arrhythmogenic Ventricular Dysplasia, Left Dominant Form,Myopathy, Myofibrillar, 3,Sick Sinus Syndrome,Multiminicore Disease,Cardiomyopathy, Familial Hypertrophic, 4,Cardiomyopathy, Dilated, 1a,Congestive Heart Failure,Myopathy, Myofibrillar, 4,Left Ventricular Noncompaction 2,Foot Drop,Myopathy, Myofibrillar, 5,Rhabdomyosarcoma,Rigid Spine Muscular Dystrophy 1,Epidermolysis Bullosa Simplex With Muscular Dystrophy,Thymoma,Thymus Cancer,Dendritic Cell Thymoma,Respiratory Failure,Centronuclear Myopathy,Myopathy, Myofibrillar, 9, With Early Respiratory Failure,Cardiomyopathy, Dilated, 1g,Congenital Myasthenic Syndrome,Cardiomyopathy, Familial Hypertrophic, 9,Cardiomyopathy, Dilated, 1h,Orthostatic Intolerance,Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant,Lung Squamous Cell Carcinoma,Restrictive Cardiomyopathy,Extrinsic Cardiomyopathy,Lambert-Eaton Myasthenic Syndrome,Arrhythmogenic Right Ventricular Cardiomyopathy,Brugada Syndrome,Muscle Hypertrophy,Salih Myopathy,Nonaka Myopathy,Primary Cutaneous Amyloidosis,Distal Arthrogryposis,Familial Atrial Fibrillation,Hypermethioninemia Due To Adenosine Kinase Deficiency,Atrioventricular Block,Third-Degree Atrioventricular Block,Barth Syndrome,Cardioneuromyopathy With Hyaline Masses And Nemaline Rods,Cardiomyopathy, Familial Hypertrophic, 1,Wolff-Parkinson-White Syndrome,Muscular Dystrophy-Dystroglycanopathy , Type C, 5,Intrinsic Cardiomyopathy,Peripartum Cardiomyopathy,Lipoprotein Quantitative Trait Locus,Atrial Fibrillation,Scoliosis,Muscular Dystrophy, Duchenne Type,Myopathy, Centronuclear, X-Linked,Cardiac Arrest,Inguinal Hernia,Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 2,Myasthenia Gravis,Left Ventricular Noncompaction,Lethal Congenital Contracture Syndrome,Myopathy, Centronuclear, 2,Batten-Turner Congenital Myopathy,Miyoshi Muscular Dystrophy,Tibial Muscular Dystrophy, Tardive,Cardiomyopathy, Dilated, 1b |
1tki_b | Q8WZ42 | ENSG00000155657 | TTN | 99.50 | 2.60E-18 | 3.00E-22 | 167.70 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | BIK1 At2g39660 F12L6.32 F17A14.3 |
Serine/threonine-protein kinase BIK1 (EC 2.7.11.1) (Protein BOTRYTIS-INDUCED KINASE 1) |
2.7.11.1 | Arabidopsis thaliana | 5tos_a | O48814 | 99.40 | 4.50E-18 | 5.10E-22 | 171.50 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | MAP3K8 COT ESTF |
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) |
2.7.11.25 | Homo sapiens | Indolent Plasma Cell Myeloma,Paronychia,Skin Lipoma,Rheumatoid Arthritis,Lung Cancer |
4y85_b | P41279 | ENSG00000107968 | MAP3K8 | 99.50 | 9.10E-19 | 1.10E-22 | 171.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | ROCK2 |
Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) |
2.7.11.1 | Bos taurus | 2f2u_b | Q28021 | 99.50 | 1.70E-18 | 1.90E-22 | 176.30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | MAP3K5 ASK1 MAPKKK5 MEKK5 |
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) |
2.7.11.25 | Homo sapiens | Liver Disease,Non-Alcoholic Fatty Liver Disease,Pyriform Sinus Cancer,Fatty Liver Disease,Alzheimer Disease,Glottis Squamous Cell Carcinoma,Partial Third-Nerve Palsy,Neural Tube Defects,Huntington Disease |
5uox_a | Q99683 | ENSG00000197442 | MAP3K5 | 99.40 | 6.40E-18 | 7.80E-22 | 157.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | ABL1 ABL JTK7 |
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) |
2.7.10.2 | Homo sapiens | Heart Disease,Childhood Acute Lymphocytic Leukemia,Childhood T-Cell Acute Lymphoblastic Leukemia,Myeloid And Lymphoid Neoplasms Associated With Pdgfra Rearrangement,Chronic Neutrophilic Leukemia,Melanoma,Chronic Eosinophilic Leukemia,Leukemia, Chronic Myeloid,B-Lymphoblastic Leukemia/Lymphoma,B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1,B-Lymphoblastic Leukemia/Lymphoma With Hypodiploidy,B-Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like,B-Lymphoblastic Leukemia/Lymphoma With Iamp21,Lung Large Cell Carcinoma,Blood Platelet Disease,Essential Thrombocythemia,Myeloproliferative Neoplasm,Testicular Leukemia,Philadelphia-Negative Chronic Myeloid Leukemia,Leukemia,Mixed Phenotype Acute Leukemia,Myelophthisic Anemia,Blood Coagulation Disease,Hypereosinophilic Syndrome,Childhood Leukemia,Leukemia, Acute Myeloid,Bone Marrow Cancer,Myelodysplastic/Myeloproliferative Neoplasm,Hematologic Cancer,Leukemia, Acute Lymphoblastic,Moyamoya Angiopathy,Polycythemia,Leiomyomatosis,Central Nervous System Leukemia,Precursor T-Cell Acute Lymphoblastic Leukemia,Acquired Polycythemia,T-Cell Prolymphocytic Leukemia,Chronic Leukemia,Cockayne Syndrome,Prolymphocytic Leukemia,Lip And Oral Cavity Cancer,Ovarian Cancer,Myeloid Leukemia,T-Cell Acute Lymphoblastic Leukemia,Adult Acute Lymphocytic Leukemia,Breast Cancer,Colorectal Cancer,Congenital Heart Defects And Skeletal Malformations Syndrome,Deficiency Anemia,Leukemia, Acute Lymphoblastic 3,Retinoblastoma,Mental Retardation, Autosomal Dominant 29,Myelodysplastic Syndrome,Mental Retardation, Autosomal Dominant 33,Gastrointestinal Stromal Tumor,Lymphoblastic Leukemia, Acute, With Lymphomatous Features,Wilms Tumor 1,Leukemia, Chronic Lymphocytic,Dermatofibrosarcoma Protuberans,Ataxia-Telangiectasia,B-Cell Adult Acute Lymphocytic Leukemia,Atypical Chronic Myeloid Leukemia,Polycythemia Vera |
2f4j_a | P00519 | ENSG00000097007 | ABL1 | 99.40 | 5.30E-18 | 6.30E-22 | 159.90 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | BTK AGMX1 ATK BPK |
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) |
2.7.10.2 | Homo sapiens | Pneumocystosis,X-Linked Recessive Disease,Lymphopenia,Conjunctivitis,Richter'S Syndrome,Macroglobulinemia,Pyoderma,Cll/Sll,Mast-Cell Leukemia,Polyarticular Juvenile Idiopathic Arthritis,Spherocytosis, Type 5,Ecthyma,B Cell Deficiency,Lung Large Cell Carcinoma,B-Cell Lymphoma,Common Variable Immunodeficiency,Neutropenia,Agammaglobulinemia 1, Autosomal Recessive,Plasma Protein Metabolism Disease,Isolated Agammaglobulinemia,Poliomyelitis,Leukemia, Acute Myeloid,Growth Hormone Deficiency,Leukemia, Acute Lymphoblastic,Agammaglobulinemia,Bacterial Infectious Disease,Breast Cancer,Central Nervous System Hematologic Cancer,Congenital Hypogammaglobulinemia,Immunodeficiency 14,Panniculitis,Immunodeficiency 33,Lymphoma, Non-Hodgkin, Familial,Baylisascariasis,Agammaglobulinemia, X-Linked,Paralytic Poliomyelitis,Immune Deficiency Disease,Myelodysplastic Syndrome,Immunoglobulin A Deficiency 1,Wiskott-Aldrich Syndrome,X-Linked Monogenic Disease,Diffuse Large B-Cell Lymphoma,Mantle Cell Lymphoma,Lymphoplasmacytic Lymphoma,Marginal Zone B-Cell Lymphoma,Splenic Marginal Zone Lymphoma,Williams-Beuren Syndrome,Combined Oxidative Phosphorylation Deficiency 9,Mohr-Tranebjaerg Syndrome,Cd40 Ligand Deficiency,Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia,Immunodeficiency 45,Immunodeficiency With Hyper-Igm, Type 1,Leukemia, Chronic Lymphocytic,Myeloma, Multiple,Isolated Growth Hormone Deficiency,Isolated Growth Hormone Deficiency Type Iii,Waldenstroem'S Macroglobulinemia |
6aua_a | Q06187 | ENSG00000010671 | BTK | 99.40 | 4.70E-18 | 5.70E-22 | 157.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | MAP4K3 RAB8IPL1 |
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) |
2.7.11.1 | Homo sapiens | Adult-Onset Still'S Disease |
5j5t_a | Q8IVH8 | ENSG00000011566 | MAP4K3 | 99.50 | 2.00E-18 | 2.20E-22 | 172.70 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CASK LIN2 |
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) |
2.7.11.1 | Homo sapiens | Cask-Related Disorders,Cerebellar Hypoplasia,Constipation,Congenital Nystagmus,Pathologic Nystagmus,Neurofibromatosis, Type I,Fraser Syndrome 1,Cask Disorders,Cerebellar Disease,Dystonia,Glucosephosphate Dehydrogenase Deficiency,Lobular Neoplasia,X-Linked Intellectual Disability, Najm Type,Cask-Related Intellectual Disability,Microcephaly,Hypertonia,Alacrima, Achalasia, And Mental Retardation Syndrome,Disease Of Mental Health,Fg Syndrome 4,Helsmoortel-Van Der Aa Syndrome,Aland Island Eye Disease,Developmental And Epileptic Encephalopathy 8,Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia,Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency,Coffin-Siris Syndrome 1,Early Infantile Epileptic Encephalopathy,Opitz-Kaveggia Syndrome,Pontocerebellar Hypoplasia,Autism,Cerebellar Hypoplasia/Atrophy, Epilepsy, And Global Developmental Delay,Peho Syndrome |
3c0g_b | O14936 | ENSG00000147044 | CASK | 99.50 | 5.90E-19 | 6.60E-23 | 176.20 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | AKT1 PKB RAC |
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) |
2.7.11.1 | Homo sapiens | Adult Hepatocellular Carcinoma,Breast Papillomatosis,Esophageal Disease,Pancreatic Adenocarcinoma,Muscular Disease,Skin Melanoma,Liver Disease,Mitral Valve Disease,Heart Disease,Neurofibromatosis, Type Ii,Endometrial Cancer,Bile Duct Disease,Spinal Chordoma,Hepatopulmonary Syndrome,Squamous Cell Carcinoma,Pfeiffer Syndrome,Glucose Metabolism Disease,Childhood T-Cell Acute Lymphoblastic Leukemia,Hyperglycemia,Retinitis Pigmentosa,Thyroid Gland Cancer,Hair Disease,Macroglobulinemia,Lung Cancer Susceptibility 3,Kagami-Ogata Syndrome,Adenoid Cystic Carcinoma,Non-Alcoholic Fatty Liver Disease,Chordoma,Cowden Syndrome,Polycystic Kidney Disease,Microvascular Complications Of Diabetes 5,Suppression Of Tumorigenicity 12,Melanoma,Connective Tissue Disease,Ocular Hypertension,Leukemia, Chronic Myeloid,Overnutrition,Inherited Metabolic Disorder,Thyroid Gland Anaplastic Carcinoma,Diabetes Mellitus,Adenoma,Spherocytosis, Type 5,Cowden Syndrome 1,Breast Juvenile Papillomatosis,Lipid Storage Disease,Peripheral Nervous System Neoplasm,Uterine Corpus Cancer,Connective Tissue Cancer,Bone Sarcoma,Hypertrophic Cardiomyopathy,Placental Choriocarcinoma,Leukocyte Disease,Clear Cell Renal Cell Carcinoma,Hyperostosis,Alzheimer Disease,Hepatoblastoma,Rasopathy,Nasopharyngeal Disease,Myocardial Infarction,Major Depressive Disorder,Bile Duct Cancer,Intestinal Benign Neoplasm,Stroke, Ischemic,Teeth Hard Tissue Disease,Amyotrophic Lateral Sclerosis 1,Malignant Ovarian Surface Epithelial-Stromal Neoplasm,Ovary Epithelial Cancer,T-Cell Lymphoblastic Leukemia/Lymphoma,Ocular Cancer,Amelogenesis Imperfecta,Retinal Cancer,Blood Platelet Disease,Biliary Tract Disease,Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi,Infratentorial Cancer,Leptin Deficiency Or Dysfunction,Lymphatic System Disease,Neurofibromatosis, Type I,Insulin-Like Growth Factor I,Neuroblastoma,Colonic Benign Neoplasm,Subependymal Glioma,Blood Coagulation Disease,Benign Ependymoma,Pilocytic Astrocytoma,Diffuse Astrocytoma,Childhood Leukemia,Bile Duct Adenocarcinoma,Hemangioma Of Lung,Nevus, Epidermal,Distal Muscular Dystrophy With Anterior Tibial Onset,Retinal Vascular Disease,Psychotic Disorder,Leukemia, Acute Myeloid,Noonan Syndrome 1,Bone Marrow Cancer,Leber Plus Disease,Hemangioma,Leukemia, Acute Lymphoblastic,Cataract,Combined Immunodeficiency,Liver Cirrhosis,Pancreas Disease,Papilloma,Cardiovascular System Disease,Autonomic Nervous System Neoplasm,Kidney Cancer,Pleural Cancer,Basal Cell Nevus Syndrome,Cowden Syndrome 6,Bladder Cancer,Focal Segmental Glomerulosclerosis,Epithelial-Myoepithelial Carcinoma,Thymus Gland Disease,Brain Cancer,Colonic Disease,Lung Adenoma,Lung Oat Cell Carcinoma,Endometrial Adenocarcinoma,Oropharynx Cancer,Cervix Carcinoma,Ulcerative Colitis,Nervous System Disease,Osteoporosis,Anal Squamous Cell Carcinoma,Ovarian Cancer,Adenocarcinoma,Tuberous Sclerosis 2,In Situ Carcinoma,Tuberous Sclerosis,T-Cell Acute Lymphoblastic Leukemia,Eye Disease,Acute Megakaryocytic Leukemia,Breast Carcinoma In Situ,Breast Cancer,Glioblastoma,Squamous Cell Carcinoma, Head And Neck,Malignant Astrocytoma,Gliosarcoma,Parkinson Disease, Late-Onset,Colorectal Cancer,Peripheral Nervous System Disease,Nervous System Cancer,Ovarian Serous Cystadenocarcinoma,Cystadenocarcinoma,Serous Cystadenocarcinoma,Gallbladder Cancer,Hepatocellular Carcinoma,Premature Menopause,Combined Hepatocellular Carcinoma And Cholangiocarcinoma,Skin Papilloma,Partial Third-Nerve Palsy,Neurilemmoma,Rhabdomyosarcoma,Ischemia,Tongue Disease,Chronic Granulomatous Disease,Thymoma,Thymus Cancer,Ovarian Disease,Noonan Syndrome With Multiple Lentigines,Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease,Teratoma,Bipolar Disorder,Macular Degeneration, Age-Related, 1,Immunodeficiency 14,Sarcoma,Bone Osteosarcoma,Skin Carcinoma,Gastric Cancer,Breast Adenocarcinoma,Cone-Rod Dystrophy 2,Prostate Cancer,Disease Of Mental Health,Pancreatic Ductal Adenocarcinoma,Cholangiocarcinoma,Proteus Syndrome,Cervical Cancer,Toxic Encephalopathy,Ovarian Cystadenocarcinoma,Body Mass Index Quantitative Trait Locus 11,Penile Disease,Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a,Central Nervous System Cancer,Pulmonary Fibrosis, Idiopathic,Congenital Myasthenic Syndrome,Retinitis Pigmentosa 47,Respiratory System Disease,Integumentary System Disease,Skin Disease,Cervical Adenocarcinoma,Ovary Adenocarcinoma,Gastric Adenocarcinoma,Type 2 Diabetes Mellitus,Plasmacytoma,Cervical Squamous Cell Carcinoma,Lynch Syndrome,Hidradenoma,Lung Squamous Cell Carcinoma,Fragile X Syndrome,Thyroid Gland Follicular Carcinoma,Schizophrenia,Sensory System Disease,Bladder Urothelial Carcinoma,Lymphoma, Non-Hodgkin, Familial,Skeletal Muscle Cancer,Muscle Cancer,Small Cell Cancer Of The Lung,Immunodeficiency 36,Hypotrichosis 1,Exanthem,Esophageal Cancer,Severe Congenital Neutropenia,Respiratory System Benign Neoplasm,Reproductive Organ Benign Neoplasm,Gastrointestinal System Benign Neoplasm,Immune Deficiency Disease,Myelodysplastic Syndrome,Meningioma, Radiation-Induced,Wiskott-Aldrich Syndrome,X-Linked Monogenic Disease,Autosomal Genetic Disease,Diffuse Large B-Cell Lymphoma,Ewing Sarcoma,Mantle Cell Lymphoma,Peripheral T-Cell Lymphoma,Tuberous Sclerosis 1,Hashimoto Thyroiditis,Gastrointestinal Stromal Tumor,Diabetic Encephalopathy,Tongue Squamous Cell Carcinoma,Oral Squamous Cell Carcinoma,Huntington Disease,Renal Cell Carcinoma, Nonpapillary,Nasopharyngeal Carcinoma,Hypertension, Essential,Meningioma, Familial,Pre-Malignant Neoplasm,Lymphatic System Cancer,Ductal Carcinoma In Situ,Estrogen-Receptor Positive Breast Cancer,Cell Type Benign Neoplasm,Cardiovascular Organ Benign Neoplasm,Uterine Benign Neoplasm,Acquired Metabolic Disease,Kaposi Sarcoma,Colitis,Klippel-Trenaunay-Weber Syndrome,Gallbladder Disease,Leukemia, Chronic Lymphocytic,Amelogenesis Imperfecta, Type Ig,Systemic Lupus Erythematosus,Pelizaeus-Merzbacher Disease,Rett Syndrome,Myeloma, Multiple,Medulloblastoma,Spinal Disease,Autism,Melanoma, Cutaneous Malignant 1,Melanoma, Uveal,Lymphoproliferative Syndrome,Lung Cancer,Palmoplantar Keratoderma, Bothnian Type,Oculoectodermal Syndrome,Osteogenic Sarcoma,Pancreatic Cancer |
4gv1_a | P31749 | ENSG00000142208 | AKT1 | 99.40 | 4.50E-18 | 5.10E-22 | 167.70 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | RPS6KA1 MAPKAPK1A RSK1 |
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) |
2.7.11.1 | Homo sapiens | Tuberous Sclerosis 2,Tuberous Sclerosis,Cardiomyopathy, Familial Hypertrophic, 4,Disease Of Mental Health,Adrenal Cortical Adenocarcinoma,Dyskeratosis Congenita, Autosomal Dominant 3,Tuberous Sclerosis 1,Coffin-Lowry Syndrome,Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease |
4nif_d | Q15418 | ENSG00000117676 | RPS6KA1 | 99.50 | 2.30E-18 | 2.60E-22 | 169.80 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | MAP3K14 NIK |
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) |
2.7.11.25 | Homo sapiens | T-Cell Lymphoblastic Leukemia/Lymphoma,Nik Deficiency,Trichohepatoenteric Syndrome 1,Pancreatic Adenosquamous Carcinoma,Pancreatic Ductal Adenocarcinoma,Immunodeficiency 50 |
4idv_c | Q99558 | ENSG00000006062 | MAP3K14 | 99.50 | 2.60E-18 | 3.00E-22 | 169.70 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | OXSR1 KIAA1101 OSR1 |
Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) |
2.7.11.1 | Homo sapiens | Bartter Disease,Arthrogryposis, Distal, Type 3,Hypomagnesemia 4, Renal,Distal Arthrogryposis,Hypomagnesemia 3, Renal |
2vwi_c | O95747 | ENSG00000172939 | OXSR1 | 99.50 | 2.10E-18 | 2.60E-22 | 163.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CDK5 CDKN5 |
Cyclin-dependent-like kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) |
2.7.11.1 | Homo sapiens | Cerebellar Hypoplasia,Supranuclear Palsy, Progressive, 1,Polycystic Kidney Disease,Dyslexia,Alzheimer Disease,Amyotrophic Lateral Sclerosis 1,Transient Cerebral Ischemia,Giant Axonal Neuropathy 2,Motor Neuron Disease,Neuroblastoma,Hereditary Spastic Paraplegia,Nephronophthisis,Alzheimer Disease 9,Scrapie,Parkinson Disease, Late-Onset,Lissencephaly With Cerebellar Hypoplasia,Pick Disease Of Brain,Ischemia,Developmental And Epileptic Encephalopathy 5,Disease Of Mental Health,Toxic Encephalopathy,Dementia, Lewy Body,Lissencephaly,Aneurysmal Bone Cysts,Lissencephaly 7 With Cerebellar Hypoplasia,Syndromic Intellectual Disability,Non-Syndromic Intellectual Disability,Multiple System Atrophy 1,Myasthenic Syndrome, Congenital, 19,Primary Autosomal Recessive Microcephaly,C Syndrome,Lung Cancer |
4au8_b | Q00535 | ENSG00000164885 | CDK5 | 99.50 | 6.60E-19 | 8.00E-23 | 166.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | STRADA LYK5 STRAD |
STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) |
Homo sapiens | Epilepsy,Polyhydramnios,Endometrial Squamous Cell Carcinoma,Breast Cancer,Megalencephaly,Benign Epilepsy With Centrotemporal Spikes,Scheuermann Disease,Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy |
2wtk_b | Q7RTN6 | ENSG00000266173 | STRADA | 99.40 | 5.70E-18 | 6.50E-22 | 169.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
YDL214C | PRR2 | SGDID:S000002373 | CDC42BPB KIAA1124 |
Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) |
2.7.11.1 | Homo sapiens | Myotonic Dystrophy,Epidermolysis Bullosa Simplex, Dowling-Meara Type |
5ote_a | Q9Y5S2 | ENSG00000198752 | CDC42BPB | 99.50 | 1.90E-18 | 2.20E-22 | 176.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | PLK4 SAK STK18 |
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) |
2.7.11.21 | Homo sapiens | Congenital Nervous System Abnormality,Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome,Colorectal Cancer,Microcephaly,Seckel Syndrome,Microcephaly And Chorioretinopathy, Autosomal Recessive, 2,Isolated Growth Hormone Deficiency,Primary Autosomal Recessive Microcephaly,Joubert Syndrome 1,Isolated Growth Hormone Deficiency, Type Ia |
3cok_b | O00444 | ENSG00000142731 | PLK4 | 99.50 | 3.80E-18 | 4.50E-22 | 161.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CDK2 CDKN2 |
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) |
2.7.11.22 | Homo sapiens | Pancreatic Adenocarcinoma,Endometrial Cancer,Smooth Muscle Tumor,Melanoma,Endometrial Hyperplasia,Leukemia, Chronic Myeloid,Leiomyosarcoma,Ocular Cancer,Retinal Cancer,Neuroblastoma,Leukemia, Acute Myeloid,Leukemia, Acute Lymphoblastic,Bladder Cancer,Lung Adenoma,Laryngeal Squamous Cell Carcinoma,Ovarian Cancer,Testicular Cancer,Eye Disease,Uterine Sarcoma,Breast Cancer,Glioblastoma,Squamous Cell Carcinoma, Head And Neck,Colorectal Cancer,Nervous System Cancer,Hepatocellular Carcinoma,Microcephaly,Pheochromocytoma,Skin Carcinoma,Gastric Cancer,Prostate Cancer,Cervical Cancer,Cecal Benign Neoplasm,Retinoblastoma,Sensory System Disease,Trichothiodystrophy 5, Nonphotosensitive,Mantle Cell Lymphoma,Gastrointestinal Stromal Tumor,Cecum Adenoma,Leukemia, Chronic Lymphocytic,Ataxia-Telangiectasia,Melanoma, Cutaneous Malignant 1,Lung Cancer,Pancreatic Cancer |
4i3z_c | P24941 | ENSG00000123374 | CDK2 | 99.50 | 2.80E-18 | 3.30E-22 | 162.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CDK13 CDC2L CDC2L5 CHED KIAA1791 |
Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) |
2.7.11.22,2.7.11.23, | Homo sapiens | Corneal Endothelial Dystrophy,Neuroblastoma,Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder,Microcephaly,Corneal Dystrophy, Posterior Polymorphous, 1,Spinocerebellar Ataxia 14,Strabismus,White-Sutton Syndrome |
5efq_a | Q14004 | ENSG00000065883 | CDK13 | 99.50 | 2.60E-18 | 3.00E-22 | 169.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | MAP4K1 HPK1 |
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) |
2.7.11.1 | Homo sapiens | 6cqd_b | Q92918 | ENSG00000104814 | MAP4K1 | 99.50 | 1.90E-18 | 2.30E-22 | 164.70 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
YDL214C | PRR2 | SGDID:S000002373 | RPS6KA5 MSK1 |
Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) |
2.7.11.1 | Homo sapiens | Septic Myocarditis,Coffin-Lowry Syndrome |
3kn5_b | O75582 | ENSG00000100784 | RPS6KA5 | 99.40 | 4.80E-18 | 5.60E-22 | 165.70 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | DAPK1 DAPK |
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) |
2.7.11.1 | Homo sapiens | Squamous Cell Carcinoma,Childhood Acute Lymphocytic Leukemia,Lung Cancer Susceptibility 3,Adenoid Cystic Carcinoma,Cholecystitis,Alzheimer Disease,B-Cell Lymphoma,Mixed Oligodendroglioma-Astrocytoma,Transitional Cell Carcinoma,Bladder Cancer,Tuberous Sclerosis 2,Parkinson Disease, Late-Onset,Colorectal Cancer,Pediatric Lymphoma,Oligodendroglioma,Central Neurocytoma,Ischemia,Gastric Cancer,Pancreatic Ductal Adenocarcinoma,Cholangiocarcinoma,Cervical Cancer,Cervical Squamous Cell Carcinoma,Myelodysplastic Syndrome,Nasopharyngeal Carcinoma,Lung Cancer |
2x0g_a | P53355 | ENSG00000196730 | DAPK1 | 99.50 | 1.40E-18 | 1.60E-22 | 170.70 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | SRK2I 41K OSKL2 SNRK2.3 At5g66880 MUD21.14 |
Serine/threonine-protein kinase SRK2I (EC 2.7.11.1) (OST1-kinase-like 2) (Protein ATHPROKIN B) (SNF1-related kinase 2.3) (SnRK2.3) |
2.7.11.1 | Arabidopsis thaliana | 3uc3_a | Q39193 | 99.40 | 5.40E-18 | 6.10E-22 | 168.10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | Taok2 Tao2 |
Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) |
2.7.11.1 | Rattus norvegicus | 1u5r_b | Q9JLS3 | 99.50 | 3.30E-18 | 3.70E-22 | 170.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | cgd4_240 |
cgd4_240 |
Cryptosporidium parvum | 3eb0_a | A3FQN0 | 99.40 | 7.60E-18 | 8.50E-22 | 170.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
YDL214C | PRR2 | SGDID:S000002373 | CSNK2A2 CK2A2 |
Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) |
2.7.11.1 | Homo sapiens | Connective Tissue Disease,Neonatal Leukemia,Distal Muscular Dystrophy With Anterior Tibial Onset,Spermatogenic Failure 50,Breast Adenocarcinoma,Theileriasis,Spermatogenic Failure 9 |
6hmq_a | P19784 | ENSG00000070770 | CSNK2A2 | 99.60 | 1.00E-19 | 1.10E-23 | 182.30 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | MAPK7 BMK1 ERK5 PRKM7 |
Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) |
2.7.11.24 | Homo sapiens | Bone Cancer,Noma,Primary Bone Cancer,Dilated Cardiomyopathy,Breast Cancer,Prostate Cancer,Osteogenesis Imperfecta, Type Xviii,Scoliosis, Isolated 1,Scoliosis |
4zsg_a | Q13164 | ENSG00000166484 | MAPK7 | 99.50 | 1.60E-18 | 1.90E-22 | 170.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | DYRK2 |
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) |
2.7.12.1 | Homo sapiens | 4azf_a | Q92630 | ENSG00000127334 | DYRK2 | 99.50 | 7.60E-19 | 8.40E-23 | 180.10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
YDL214C | PRR2 | SGDID:S000002373 | PBL2 APK2A KIN1 At1g14370 F14L17.14 |
Probable serine/threonine-protein kinase PBL2 (EC 2.7.11.1) (PBS1-like protein 2) (Protein kinase 2A) |
2.7.11.1 | Arabidopsis thaliana | 6j5t_d | O49839 | 99.50 | 1.40E-18 | 1.60E-22 | 177.50 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |||
YDL214C | PRR2 | SGDID:S000002373 | GSK3B |
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) |
2.7.11.26 | Homo sapiens | Liver Disease,Endometrial Cancer,Epilepsy,Polycystic Kidney Disease,Diabetes Mellitus,Alzheimer Disease,Major Depressive Disorder,Neuroblastoma,Cervical Non-Keratinizing Squamous Cell Carcinoma,Barbiturate Dependence,Alzheimer Disease 9,Dementia,Fallopian Tube Serous Adenocarcinoma,Breast Cancer,Parkinson Disease, Late-Onset,Colorectal Cancer,Parkinson Disease 1, Autosomal Dominant,Hepatocellular Carcinoma,Bipolar Disorder,Gastric Cancer,Prostate Cancer,Disease Of Mental Health,Type 2 Diabetes Mellitus,Schizophrenia,Ophthalmomyiasis,Familial Adenomatous Polyposis,Severe Congenital Neutropenia,Aneurysmal Bone Cysts,Attention Deficit-Hyperactivity Disorder,Medulloblastoma,Frontotemporal Dementia,Pancreatic Cancer |
1j1b_b | P49841 | ENSG00000082701 | GSK3B | 99.50 | 2.10E-19 | 2.40E-23 | 182.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | AAK1 KIAA1048 |
AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) |
2.7.11.1 | Homo sapiens | Parkinson Disease, Late-Onset,Cataract 8, Multiple Types,Hepatitis C Virus,Rabies |
5te0_a | Q2M2I8 | ENSG00000115977 | AAK1 | 99.40 | 7.20E-18 | 8.30E-22 | 165.90 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | WNK3 KIAA1566 PRKWNK3 |
Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) |
2.7.11.1 | Homo sapiens | Bartter Disease,Renal Tubular Transport Disease,Pseudohypoaldosteronism,Agenesis Of The Corpus Callosum With Peripheral Neuropathy,Arthrogryposis, Distal, Type 3,Liddle Syndrome 1,Hypomagnesemia 4, Renal,Distal Arthrogryposis,Hypertension, Essential,Syndromic X-Linked Intellectual Disability Siderius Type,Gitelman Syndrome |
5o2c_a | Q9BYP7 | ENSG00000196632 | WNK3 | 99.50 | 1.90E-18 | 2.20E-22 | 174.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | FES FPS |
Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) |
2.7.10.2 | Homo sapiens | Melanoma,Leukemia, Chronic Myeloid,Latent Syphilis,Sjogren-Larsson Syndrome,Leukemia,Myeloid Leukemia,Sarcoma,Ewing Sarcoma Of Bone,Neurofibrosarcoma,Acute Promyelocytic Leukemia,Miller-Dieker Lissencephaly Syndrome,Myopathy, Centronuclear, 2 |
3cbl_a | P07332 | ENSG00000182511 | FES | 99.40 | 5.40E-18 | 6.30E-22 | 167.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | DMPK DM1PK MDPK |
Myotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase) |
2.7.11.1 | Homo sapiens | Muscular Disease,Fuchs' Endothelial Dystrophy,Myopathy,Muscle Tissue Disease,Neuromuscular Disease,Hypertrophic Cardiomyopathy,Myotonic Disease,Myotonic Dystrophy 1,Muscular Dystrophy,Myotonic Dystrophy,Spinocerebellar Ataxia 8,Myotonic Cataract,Cataract,Oculopharyngeal Muscular Dystrophy,Hair Follicle Neoplasm,Myotonic Dystrophy 2,Myotonia,Immature Cataract,Lens Disease,Autosomal Dominant Cerebellar Ataxia,Disease Of Mental Health,Fragile X Syndrome,Huntington Disease-Like 2,First-Degree Atrioventricular Block,Fragile X-Associated Tremor/Ataxia Syndrome,X-Linked Hereditary Ataxia,Spinal And Bulbar Muscular Atrophy, X-Linked 1,Catecholaminergic Polymorphic Ventricular Tachycardia,Frontotemporal Dementia,3-Methylglutaconic Aciduria, Type Iii |
2vd5_a | Q09013 | ENSG00000104936 | DMPK | 99.40 | 4.50E-18 | 5.10E-22 | 172.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
YDL214C | PRR2 | SGDID:S000002373 | CAMKK1 CAMKKA |
Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) |
2.7.11.17 | Homo sapiens | Tracheitis |
6ccf_b | Q8N5S9 | ENSG00000004660 | CAMKK1 | 99.50 | 2.20E-18 | 2.70E-22 | 160.90 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |