| Yeast Systematic Name | Yeast Symbol | SGDID | Analog Name | Analog Description | EC | Organism | Disease | Structure | Uniprot | Human ID | Human Symbol | HHsearch Probability | HHsearch E_value | HHsearch P_value | HHsearch Score | Flag Disease related | Flag Homo sapiens | Flag Mus musculus | Flag Danio rerio | Flag Drosophila melanogaster | Flag Caenorhabditis elegans | Flag Arabidopsis thaliana | Flag Escherichia coli |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| YGR193C | PDX1 | SGDID:S000003425 | pdhC |
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (E2) |
2.3.1.12 | Geobacillus stearothermophilus | 1ebd_c | P11961 | 97.60 | 3.40E-08 | 3.30E-12 | 66.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YGR193C | PDX1 | SGDID:S000003425 | Ta1436 |
Ta1436 |
Thermoplasma acidophilum | 2l5t_a | Q9HIA5 | 97.60 | 3.90E-08 | 4.40E-12 | 70.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
| YGR193C | PDX1 | SGDID:S000003425 | MCCC1 MCCA |
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) |
6.4.1.4 | Homo sapiens | Mucinous Intrahepatic Cholangiocarcinoma,Multiple Carboxylase Deficiency,Parkinson Disease, Late-Onset,3-Methylcrotonyl-Coa Carboxylase Deficiency,Laurence-Moon Syndrome,Biotin Deficiency,Acyl-Coa Dehydrogenase, Short-Chain, Deficiency Of,Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of,Microphthalmia, Syndromic 3,3-Methylcrotonyl-Coa Carboxylase 1 Deficiency |
2ejm_a | Q96RQ3 | ENSG00000078070 | MCCC1 | 97.10 | 4.40E-07 | 4.80E-11 | 67.80 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YGR193C | PDX1 | SGDID:S000003425 | PAE2648 |
PAE2648 |
Pyrobaculum aerophilum | 1w4i_a | Q8ZUR6 | 97.60 | 5.30E-08 | 4.70E-12 | 72.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
| YGR193C | PDX1 | SGDID:S000003425 | aceF ECs_0119 |
aceF ECs_0119 |
2.3.1.12 | Escherichia coli | 4qoy_e | Q8X966 | 97.50 | 6.20E-08 | 5.80E-12 | 67.10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | |||
| YGR193C | PDX1 | SGDID:S000003425 | cmeA AT778_05885 E8P16_04140 E8P16_10560 F1P94_04720 FW488_03645 FY801_06740 GNO00_03940 GXA88_03280 |
cmeA AT778_05885 E8P16_04140 E8P16_10560 F1P94_04720 FW488_03645 FY801_06740 GNO00_03940 GXA88_03280 |
Campylobacter jejuni | 2k32_a | Q8RTE5 | 97.20 | 3.00E-07 | 3.20E-11 | 72.20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
| YGR193C | PDX1 | SGDID:S000003425 | TTHA0184 |
TTHA0184 |
2.3.1.-,2.3.1.12, | Thermus thermophilus | 2eq8_f | Q5SLV9 | 97.50 | 5.70E-08 | 5.50E-12 | 65.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YGR193C | PDX1 | SGDID:S000003425 | TTHA0232 |
TTHA0232 |
2.3.1.- | Thermus thermophilus | 2eq9_f | Q5SLR1 | 97.50 | 7.40E-08 | 7.00E-12 | 64.90 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YGR193C | PDX1 | SGDID:S000003425 | TTHA0288 |
TTHA0288 |
2.3.1.61 | Thermus thermophilus | 2eq7_c | Q5SLK5 | 97.60 | 3.00E-08 | 2.80E-12 | 66.60 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YGR193C | PDX1 | SGDID:S000003425 | accB fabE b3255 JW3223 |
Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP) |
Escherichia coli | 1bdo_a | P0ABD8 | 97.90 | 5.00E-09 | 4.20E-13 | 82.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | ||||
| YGR193C | PDX1 | SGDID:S000003425 | DBT BCATE2 |
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) |
2.3.1.168 | Homo sapiens | Autoimmune Cholangitis,Primary Biliary Cholangitis,Shipyard Eye,Intermediate Maple Syrup Urine Disease,Barth Syndrome,Maple Syrup Urine Disease |
1k8o_a | P11182 | ENSG00000137992 | DBT | 97.50 | 6.90E-08 | 7.60E-12 | 71.90 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YGR193C | PDX1 | SGDID:S000003425 | DLAT DLTA |
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) |
2.3.1.12 | Homo sapiens | Liver Disease,Nystagmus 7, Congenital, Autosomal Dominant,Chronic Cholangitis,Cholangitis,Autoimmune Hepatitis,Mycobacterium Gordonae,Autoimmune Cholangitis,Ulnar Neuropathy,Ulnar Nerve Lesion,Vaginitis,Primary Biliary Cholangitis,Biliary Tract Disease,Nystagmus 2, Congenital, Autosomal Dominant,Autoimmune Disease,Chancroid,Suppurative Cholangitis,Lactic Acidosis,Cholangitis, Primary Sclerosing,Halothane Hepatitis,Pyruvate Dehydrogenase E2 Deficiency,Nystagmus 4, Congenital, Autosomal Dominant,Autoimmune Disease Of Gastrointestinal Tract,Pyruvate Dehydrogenase E1-Alpha Deficiency |
1y8n_b | P10515 | ENSG00000150768 | DLAT | 97.30 | 2.00E-07 | 1.90E-11 | 76.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YGR193C | PDX1 | SGDID:S000003425 | sucB b0727 JW0716 |
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) |
2.3.1.61 | Escherichia coli | 1bal_a | P0AFG6 | 97.50 | 6.50E-08 | 6.00E-12 | 68.80 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | |||
| YGR193C | PDX1 | SGDID:S000003425 | aceF b0115 JW0111 |
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (E2) |
2.3.1.12 | Escherichia coli | 2k7v_a | P06959 | 97.10 | 4.50E-07 | 5.10E-11 | 65.20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | |||
| YGR193C | PDX1 | SGDID:S000003425 | BB_0141 |
BB_0141 |
Borrelia burgdorferi | 4kku_d | O51166 | 97.00 | 8.50E-07 | 9.20E-11 | 79.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
| YGR193C | PDX1 | SGDID:S000003425 | ACACB ACC2 ACCB |
Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) |
6.4.1.2 | Homo sapiens | Fatty Liver Disease,Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus,Biotin Deficiency |
2kcc_a | O00763 | ENSG00000076555 | ACACB | 97.10 | 5.30E-07 | 5.70E-11 | 66.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YGR193C | PDX1 | SGDID:S000003425 | PDHX PDX1 |
Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) |
Homo sapiens | Primary Biliary Cholangitis,Lactic Acidosis,Pyruvate Dehydrogenase E3-Binding Protein Deficiency,Pyruvate Dehydrogenase E1-Alpha Deficiency,Leigh Syndrome |
1zy8_n | O00330 | ENSG00000110435 | PDHX | 99.50 | 3.60E-19 | 3.40E-23 | 164.50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YGR193C | PDX1 | SGDID:S000003425 | yngHB BSU18239 |
Biotin/lipoyl attachment protein (BLAP) |
Bacillus subtilis | 1z6h_a | C0H419 | 97.10 | 5.30E-07 | 6.20E-11 | 61.80 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |