| Yeast Systematic Name | Yeast Symbol | SGDID | Analog Name | Analog Description | EC | Organism | Disease | Structure | Uniprot | Human ID | Human Symbol | HHsearch Probability | HHsearch E_value | HHsearch P_value | HHsearch Score | Flag Disease related | Flag Homo sapiens | Flag Mus musculus | Flag Danio rerio | Flag Drosophila melanogaster | Flag Caenorhabditis elegans | Flag Arabidopsis thaliana | Flag Escherichia coli |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| YOR360C | PDE2 | SGDID:S000005887 | PDE4D DPDE3 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) |
3.1.4.53 | Homo sapiens | Pseudopseudohypoparathyroidism,Pseudohypoparathyroidism,Pseudohypoparathyroidism, Type Ia,Cerebrovascular Disease,Spinal Stenosis,Myocardial Infarction,Stroke, Ischemic,Ocular Hypotension,Hypertension And Brachydactyly Syndrome,Osseous Heteroplasia, Progressive,Hypothyroidism, Congenital, Nongoitrous, 1,Acrodysostosis With Multiple Hormone Resistance,Atrial Fibrillation And Stroke,Respiratory Failure,Acrodysostosis,Disease Of Mental Health,Chromosome 5q12 Deletion Syndrome,Schizophrenia 1,Brachydactyly,Pulmonary Disease, Chronic Obstructive,Acrodysostosis 2 With Or Without Hormone Resistance,Hermansky-Pudlak Syndrome 1 |
1q9m_d | Q08499 | ENSG00000113448 | PDE4D | 100.00 | 1.20E-55 | 1.00E-59 | 457.60 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YOR360C | PDE2 | SGDID:S000005887 | PDE10A |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) |
3.1.4.17,3.1.4.35, | Homo sapiens | Choreatic Disease,Disease Of Mental Health,Lidocaine Allergy,Schizophrenia,Huntington Disease,Dyskinesia, Limb And Orofacial, Infantile-Onset,Striatal Degeneration, Autosomal Dominant 2 |
2our_a | Q9Y233 | ENSG00000112541 | PDE10A | 100.00 | 2.10E-55 | 1.70E-59 | 451.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YOR360C | PDE2 | SGDID:S000005887 | Pde10a |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) |
3.1.4.17,3.1.4.35, | Rattus norvegicus | 3lxg_a | Q9QYJ6 | 100.00 | 5.10E-52 | 4.30E-56 | 421.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YOR360C | PDE2 | SGDID:S000005887 | PDEB1 |
PDEB1 |
3.1.4.- | Trypanosoma brucei | 6fe3_b | Q8WQX9 | 100.00 | 1.60E-54 | 1.30E-58 | 449.20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YOR360C | PDE2 | SGDID:S000005887 | PDE2 |
PDE2 |
3.1.4.- | Candida albicans | 6cpu_a | Q8NJP9 | 100.00 | 4.90E-82 | 3.90E-86 | 690.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YOR360C | PDE2 | SGDID:S000005887 | PDEB1 |
PDEB1 |
3.1.4.- | Leishmania major | 2r8q_b | Q6S996 | 100.00 | 1.80E-57 | 1.40E-61 | 471.20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YOR360C | PDE2 | SGDID:S000005887 | PDEC C3747_13g415 |
PDEC C3747_13g415 |
3.1.4.- | Trypanosoma cruzi | 3v93_h | Q53I60 | 100.00 | 2.90E-53 | 2.30E-57 | 437.30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YOR360C | PDE2 | SGDID:S000005887 | Tb09.160.3630 |
Tb09.160.3630 |
3.1.4.- | Trypanosoma brucei | 5h2q_a | Q38F42 | 100.00 | 1.90E-54 | 1.60E-58 | 444.90 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YOR360C | PDE2 | SGDID:S000005887 | PDE5A PDE5 |
cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) |
3.1.4.35 | Bos taurus | 3jbq_b | Q28156 | 100.00 | 1.70E-54 | 1.40E-58 | 443.90 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YOR360C | PDE2 | SGDID:S000005887 | PDE7A |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) |
3.1.4.53 | Homo sapiens | Impotence,Low Compliance Bladder,Sexual Disorder,Leukemia, Chronic Lymphocytic |
1zkl_a | Q13946 | ENSG00000205268 | PDE7A | 100.00 | 6.40E-57 | 5.20E-61 | 466.00 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YOR360C | PDE2 | SGDID:S000005887 | PDE3B |
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) |
3.1.4.17 | Homo sapiens | Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus,Brachydactyly,Pseudohypoparathyroidism, Type Ii,Leukemia, Chronic Lymphocytic,Pelizaeus-Merzbacher Disease,Palmoplantar Keratoderma, Bothnian Type |
1so2_c | Q13370 | ENSG00000152270 | PDE3B | 100.00 | 1.70E-56 | 1.40E-60 | 471.20 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YOR360C | PDE2 | SGDID:S000005887 | PDE3B |
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) |
3.1.4.17 | Homo sapiens | Body Mass Index Quantitative Trait Locus 11,Type 2 Diabetes Mellitus,Brachydactyly,Pseudohypoparathyroidism, Type Ii,Leukemia, Chronic Lymphocytic,Pelizaeus-Merzbacher Disease,Palmoplantar Keratoderma, Bothnian Type |
1so2_a | Q13370 | 100.00 | 2.30E-63 | 1.70E-67 | 521.20 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| YOR360C | PDE2 | SGDID:S000005887 | PDE4B DPDE4 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) |
3.1.4.53 | Homo sapiens | Ocular Hypotension,Bipolar Disorder,Respiratory Failure,Acrodysostosis,Disease Of Mental Health,Schizophrenia,Schizophrenia 1,Brugada Syndrome 3,Autism |
3ly2_b | Q07343 | ENSG00000184588 | PDE4B | 100.00 | 4.20E-57 | 3.40E-61 | 468.10 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YOR360C | PDE2 | SGDID:S000005887 | PDE1B PDE1B1 PDES1B |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE) |
3.1.4.17 | Homo sapiens | 5b25_a | Q01064 | ENSG00000123360 | PDE1B | 100.00 | 3.20E-53 | 2.70E-57 | 435.80 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YOR360C | PDE2 | SGDID:S000005887 | PDE6B PDEB |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35) |
3.1.4.35 | Bos taurus | 6mzb_b | P23439 | 100.00 | 1.70E-50 | 1.50E-54 | 458.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YOR360C | PDE2 | SGDID:S000005887 | PDE6A PDEA |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1) |
3.1.4.35 | Bos taurus | 6mzb_a | P11541 | 100.00 | 1.10E-50 | 9.70E-55 | 460.10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YOR360C | PDE2 | SGDID:S000005887 | PDE9A |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) |
3.1.4.35 | Homo sapiens | Heart Disease,B-Lymphoblastic Leukemia/Lymphoma With Iamp21 |
6a3n_b | O76083 | ENSG00000160191 | PDE9A | 100.00 | 9.40E-55 | 7.80E-59 | 444.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YOR360C | PDE2 | SGDID:S000005887 | PDE5A PDE5 |
cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) |
3.1.4.35 | Homo sapiens | Tricuspid Valve Insufficiency,Heart Disease,Articulation Disorder,Migraine With Or Without Aura 1,Retinitis Pigmentosa 46,Urethral Stricture,Impotence,Optic Nerve Disease,Priapism,Hypogonadism,Diabetes Mellitus,Otosalpingitis,Myocardial Infarction,Neurogenic Bladder,Low Compliance Bladder,Female Stress Incontinence,Eustachian Tube Disease,Diastolic Heart Failure,Chronic Pulmonary Heart Disease,Vasculogenic Impotence,Inhibited Female Orgasm,Cardiovascular System Disease,Transient Global Amnesia,Persistent Fetal Circulation Syndrome,Paraphimosis,Psychosexual Disorder,Pulmonary Venoocclusive Disease,Hepatic Encephalopathy,Nasopharyngitis,Diaphragm Disease,Pre-Eclampsia,Premature Ejaculation,Parkinson Disease 1, Autosomal Dominant,Hypoactive Sexual Desire Disorder,Bladder Neck Obstruction,Sexual Sadism,Lipid Metabolism Disorder,Congestive Heart Failure,Ureterolithiasis,Ischemia,Pulmonary Valve Insufficiency,Meconium Aspiration Syndrome,Prostatitis,Disease Of Mental Health,Pulmonary Hypertension,Body Mass Index Quantitative Trait Locus 11,Penile Disease,Limited Scleroderma,Raynaud Disease,Type 2 Diabetes Mellitus,Diaphragmatic Hernia, Congenital,Tricuspid Valve Disease,Pulmonary Disease, Chronic Obstructive,Retinitis Pigmentosa 72,Hypertension, Essential,Sexual Disorder,Lipoprotein Quantitative Trait Locus,Stuttering,Nonarteritic Anterior Ischemic Optic Neuropathy |
3hc8_a | O76074 | ENSG00000138735 | PDE5A | 100.00 | 3.10E-55 | 2.60E-59 | 448.30 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YOR360C | PDE2 | SGDID:S000005887 | PDE8A |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) |
3.1.4.53 | Homo sapiens | 3ecm_a | O60658 | ENSG00000073417 | PDE8A | 100.00 | 1.00E-56 | 8.40E-61 | 462.00 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| YOR360C | PDE2 | SGDID:S000005887 | PDE2A |
cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) |
3.1.4.17 | Homo sapiens | Retinitis Pigmentosa,Paroxysmal Dystonia,Paroxysmal Dyskinesia,Choreatic Disease,Retinal Degeneration,Intellectual Developmental Disorder With Paroxysmal Dyskinesia Or Seizures,Scrotum Squamous Cell Carcinoma,Scrotal Carcinoma,Cone-Rod Dystrophy 19 |
5u00_d | O00408 | ENSG00000186642 | PDE2A | 100.00 | 7.90E-56 | 6.50E-60 | 456.40 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| YOR360C | PDE2 | SGDID:S000005887 | PDE9A |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) |
3.1.4.35 | Pan troglodytes | 4qge_b | H2QL32 | 100.00 | 7.70E-58 | 6.00E-62 | 494.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| YOR360C | PDE2 | SGDID:S000005887 | PTSG_02023 |
PTSG_02023 |
3.1.4.- | Salpingoeca rosetta | 5vyd_b | F2TZN0 | 100.00 | 4.80E-55 | 4.00E-59 | 445.60 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |