Eli Arama's Lab Cellular Destruction Mechanisms in Development

Cellular destruction processes are essential for the survival and wellbeing of all cells, tissues, and organs in virtually all organisms. The pathogenesis of many diseases, including cancer and neurodegenerative disorders is attributed to the malfunctioning of these processes. Whereas the use of cell biology and biochemistry approaches have shed invaluable light on some of the basic mechanisms involved in the regulation and execution of different cellular destruction processes, relatively much less is known about the roles and functions of these processes in development and homeostasis of the organism. One of the reasons for the slow progress in this area is the lack of appropriate physiological models available to study cellular destruction processes. [Read more]