The Elson Group 

  We are interested how cell signaling affects function in the bone system, focusing primarily on osteoclasts, the only cells in our bodies that degrade bone. Osteoclasts are fascinating cells that offer insights into basic biological questions such as cell adhesion, cell differentiation, and cell-to-cell fusion. In addition, these cells are highly relevant to understanding the basic biology of bone, in normal health and development as well as in major diseases, such as osteoporosis, osteopetrosis, and cancer-related bone loss. Our goal is to understand the basic biology of these systems and to contribute towards developing treatments for diseases that affect them.

     Our studies in these contexts include protein tyrosine kinases and phosphatases as well as other molecules, and combine studies at the molecular, cellular, and whole-animal levels. We use varied methodologies such as CRISPR to generate genetically modified mice and cells, transcriptomic and proteomic profiling of relevant cells, high-end microscopy, as well as techniques in biochemistry, molecular biology and tissue culture.