GeneCards - genome-wide gene and disease databases

The GeneCards® database of human genes was launched in 1997, and has expanded since then to encompass gene-centric, disease-centric, and pathway-centric entities and relationships within the GeneCards Suite, effectively navigating the universe of human biological data - genes, proteins, cells, regulatory elements, biological pathways, and diseases - and the connections amongst them. The Suite’s integrated biomedical knowledgebase includes GeneCards, the integrated human gene database, MalaCards, the unified human disease database, PathCards, the consolidated human pathways database, and GeneLoc, the human genomic neighborhood location-based database. The Suite newest members, focusing on the emerging field of annotating the non-coding genomic “dark matter”, are GeneHancer, an innovative regulatory element database with ~400,000 enhancer and promoter entries, and GeneCaRNA, an all-inclusive gene-centric ncRNA database with ~220,000 ncRNA gene pages.



The knowledgebase amalgamates information from >150 selected sources related to genes, proteins, ncRNAs, regulatory elements, chemical compounds, drugs, splice variants, SNPs, signaling molecules, differentiation protocols, biological pathways, stem cells, genetic tests, clinical trials, diseases, publications, and more, and empowers Next Generation Sequencing (NGS) analysis by highlighting associations between genes and phenotypes, providing supporting evidence for immediate evaluation via the Suite’s NGS analysis tool VarElect, the phenotype interpreter. VarElect accepts a list of genes and phenotypes as input, and computes prioritized direct (keyword-based) and indirect (inferred from gene-to-gene associations) gene/disease connections. Rounding out the Suite are GeneAnalytics, for gene set enrichment analysis, GenesLikeMe, for finding genes with shared descriptors, and GeneALaCart, for batch queries.



The Suite’s websites, data dumps, APIs, publications, and collaborations are enjoyed by about 6 million users, including research and applied scientists, doctors, geneticists, and lay-people, in >3,000 institutions worldwide, encompassing academia, national patent offices, leading biopharma and diagnostic companies, and hospitals.



Selected GeneCards Suite Publications

Complete list of publications