Deciphering Transcriptional and Epigenetic Regulation in Pluripotent Cells

How the cell maintain its pluripotency is still largely unknown. I seek to model and analyze various pluripotent cell systems in order to decipher the epigenetic mechanisms that either maintain or induce pluripotency. Specifically I am interested in studying normal cell differentiation, stem-cell reprogramming (the process of generating stem cell from a somatic cell), and trans-differentiation.