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we have identified a new pathway for proteasomal degradation. we have evidence for this pathway to be modified in cancer cells. We found that this pathway to be regulated by metabolism. cancer cells display a unique behavior in regard to metabolism (the Warburg effect). we are investigating the possibility that the Warburg effect is important for the shift in proteasomal degradation.

we have identified a new signaling pathway that is activated in response to DNA damage. the major players of this signaling pathway are the tyrosine kinase c-Abl (a proto-oncogene), p73 (a member of p53 tumor suppressor proteins), and Yap (the downstream effector of Hippo pathway that regulates organ size). we have preliminary data to show that this pathway is involved in differentiation of muscle and Fat cells.