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Transcriptional sensitivity to nuclear mechanical outputs in muscle fibres.  

Life Sciences
Tuesday, December 1, 2020

The lab studies how mechanical inputs applied on the nucleus affect chromatin organization and transcription in muscle fibres in vivo. For our studies we use Drosophila larval muscles as a model which is sensitive to mechanical inputs, and in addition is amenable genetically, and enables live imaging at high resolution. A genomic analysis using the DamId methodology has been performed to uncover the binding profile of RNA-Pol II, Polycomb and HP1 in a mutant in which the transduction of mechanical inputs into the nuclei is impaired. The project involves the analysis of these profiles and further revealing their functional significance. The work involves molecular studies as well as high resolution imaging.