We investigate molecular, cellular, and system mechanisms of learning and memory in the mammalian brain. We do this by studying rats and humans.
In all our studies, we consider learning and memory as multilevel processes, which should be examined in real-world contexts. At the same time, these contexts should still enable reproducible, controlled experimentation, using the sophisticated tools of state-of-the-art brain research.
We are particularly interested in the processes and mechanisms that convert one-shot experiences into long-term memory ("consolidation"), and in the retrieval and post-retrieval fate of items in memory, including remodelling, extinction, suppression, erasure and forgetting.
Toward that end, in the rat, we use a combination of molecular, cellular and behavioural methods. In human research, we develop sophisticated behavioural paradigms and combine them with functional brain imaging.
In the only project in our lab that does not (yet) focus on memory, we study brain mechanisms of human courage.
A selection of our discoveries is detailed under Publications.
In both animal and human studies, we maintain close collaborations with several research centres worldwide, among them New York University, SUNY Medical Centre in NY, McGill University, The Free University in Berlin and Edinburgh University. Our work is supported in recent years by the Minerva Foundation, The Volkswagen Foundation, the Human Frontiers Science Program, The Israeli Science Foundation (ISF), The Israel-US Binational Science Foundation (BSF), and The Nella and Leon Benoziyo Center for Neurological Diseases.