The main goal of our group is to decipher the first principles of cellular self-organization processes such as protein folding, protein-protein assembly, and protein-DNA recognition. We are focused on advancing our understanding of biomolecules (the sequence-structure-function problem) using a battery of computational and theoretical methods that capture their chemical and physical nature as well as the billions of years of evolutional design.
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Lastest Publication

  • Structure, stability and specificity of the binding of ssDNA and ssRNA with proteins

    . Arumay Pal and Yaakov Levy. 2019 PLoS Computational Biology, In press
  • An NMR Confirmation for Increased Folded State Entropy Following Loop Truncation

    . Yulian Gavrilov, Shlomi Dagan, Ziv Reich, Tali Scherf, and Yaakov Levy. 2018 J Phys Chem B, 122: 10855-10860
  • Stability Effects of Protein Mutations: The Role of Long-Range Contacts

    . Lavi S. Bigman and Yaakov Levy. 2018 J Phys Chem B, 122: 11450-11459

Fields of Interest


Protein Folding and Post-translational Modifications

Protein folding has long been viewed as being rich in complexities. With the development of the energy landscape theory, our view of protein folding, however, has...

Protein-Protein Assembly

Biomolecules rarely function in isolation, hence a thorough understanding of biological processes is dependent upon an examination of complexes of biomolecules, and...

Protein-DNA recognition

Essentially, most of the biological functions of DNA require the binding of specific proteins to specific DNA sequences. For binding to occur, the protein has to...