Group Publications

  1. Piehler J, Thomas C, Christopher Garcia K, Schreiber G. Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation. Immunological Reviews. 2012 250: 317-34.

  2. Khait R, Schreiber G. FRETex: a FRET-based, high-throughput technique to analyze protein-protein interactions. Protein Eng Des Sel. 2012 11: 681-7.

  3. Phillip Y, Harel M, Khait R, Qin S, Zhou HX, Schreiber G. Binding and activity of all human alpha interferon subtypes. Biophysical J. 2012 103: 1011-9.

  4. Phillip Y, Kiss V, Schreiber G. Protein-binding dynamics imaged in a living cell. PNAS. 2012 109:1461-6 .

  5. Fleishman SJ, et al. Community-wide assessment of protein-interface modeling suggests improvements to design methodology. J Mol Biol. 2011 414: 289-302.

  6. Lavoie TB, Kalie E, Crisafulli-Cabatu S, Abramovich R, Digioia G, Moolchan K, Pestka S, Schreiber G. Binding and activity of all human alpha interferon subtypes. Cytokine. 2011 56: 282-9.

  7. Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, Nolan GP, Piehler J, Schreiber G, Garcia KC. Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons. Cell. 2011 146: 621-32.

  8. Levin D, Harari D, Schreiber G. Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment. Mol Cell Biol. 2011 31: 3252-66 .

  9. Cohavi O, Reichmann D, Abramovich R, Tesler AB, Bellapadrona G, Kokh DB, Wade RC, Vaskevich A, Rubinstein I, Schreiber G. A quantitative, real-time assessment of binding of peptides and proteins to gold surfaces. Chemistry 2011 17: 1327-36. .

  10. Schreiber G, Keating AE. Protein binding specificity versus promiscuity. Curr Opin Struct Biol. 2011 21: 50-61.

  11. Potapov V, Cohen M, Inbar Y, Schreiber G. Protein structure modelling and evaluation based on a 4-distance description of side-chain interactions. BMC Bioinformatics. 2010 11: 374.

  12. Schreiber G, Walter MR. Cytokine-receptor interactions as drug targets. Curr Opin Chem Biol. 2010 14: 511-9 .

  13. Cohavi O, Corni S, De Rienzo F, Di Felice R, Gottschalk KE, Hoefling M, Kokh D, Molinari E, Schreiber G, Vaskevich A, Wade RC. Protein-surface interactions: challenging experiments and computations. J. Mol. Recognit 2010 23: 259-62 .

  14. Kiel C, Filchtinski D, Spoerner M, Schreiber G, Kalbitzer HR, Herrmann C. Improved binding of raf to Ras.GDP is correlated with biological activity. J Biol Chem. 2009 284: 31893-902 .

  15. Rahat O, Alon U, Levy Y, Schreiber G. Understanding hydrogen-bond patterns in proteins using network motifs. Bioinformatics 2009 25: 2921-8 .

  16. Phillip Y, Sherman E, Haran G, Schreiber G. Common Crowding Agents Have Only a Small Effect on Protein-Protein Interactions. Biophysical J. 2009 97: 875-85 .

  17. Cohen M, Potapov V, Schreiber G. Four Distances between Pairs of Amino Acids Provide a Precise Description of their Interaction. PLOS Comp. 2009 ie1000470: .

  18. Moraga I, Harari D, Schreiber G, Uzé G, Pellegrini S. Receptor density is key to the interferon alpha2/beta differential activities. Mol Cell Biol, 2009. 29:4778-87 .

  19. Potapov V, Cohen M, Schreiber G. Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details. PEDS, 2009. 22: 553-60 .

  20. Cohavi O, Tobi D, Schreiber G. Docking of antizyme to ornithine decarboxylase and antizyme inhibitor using experimental mutant and double-mutant cycle data. J.Mol.Biol., 2009. 390: 503-15 .

  21. Harel, M., Spaar, A. & Schreiber, G. Fruitful and futile encounters along the association reaction between proteins. Biophys J., 2009. 96: 4237-48 .

  22. Schreiber, G., Haran, G. & Zhou, H. X. Fundamental Aspects of Protein-Protein Association Kinetics. Chem Rev, 2009. 109: 839-860 .

  23. Bravman, T., Bronnera, V., Nahshol, O. & Schreiber, G. The ProteOn XPR36™ Array System – High Throughput Kinetic Binding Analysis of Biomolecular Interactions. Cellular and Molecular Bioengineering. Cellular and Molecular Bioengineering, 2008 1: 216-228 .

  24. Kalie E, Jaitin DA, Podoplelova Y, Piehler J, Schreiber G. The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities. J Biol Chem., 2008. 283:32925-32936 .

  25. Potapov V., Reichmann D., Abramovich R., Filchtinski D., Zohar N., Ben Halevy D., Edelman M. Sobolev V., and Schreiber G. Computational redesign of a protein-protein interface for high affinity and binding specificity using modular architecture and naturally occurring template fragments. J. Mol. Biol, 2008. 384: 109-119 .

  26. Manjing Pan, Eyal Kalie, Brian J. Scaglione, Elizabeth S. Raveche, Gideon Schreiber Jerome A. Langer. Mutation of the IFNAR-1 Receptor Binding Site of Human IFN-a2 Generates Type I IFN Competitive Antagonists. Biochemistry, 2008. 47: 1051-1060 .

  27. Cohen, M., Reichmann, D., and Schreiber, G. Similar chemistry, but different bond preferences for inter versus intra-protein interactions. Proteins, 2008. 72: 741-53 .

  28. Rahat, O., Yitzhaky, A., and Schreiber, G. Cluster conservation as a novel tool for studying protein-protein interactions evolution. Proteins, 2008. 71: 621-30 .

  29. Reichmann, D., Phillip, Y., and Schreiber, G. On the contribution of water-mediated interactions to protein-complex stability. Biochemistry, 2008. 47: 1051-60 .

  30. Uze, G., Schreiber, G., Piehler, J., and Pellegrini, S. The receptor of the type I interferon family. Curr Top Microbiol Immunol. 2007 316: 71-95 .

  31. Adam, Y., Tayer, N., Rotem, D., Schreiber, G., and Schuldiner, S. The fast release of sticky protons: kinetics of substrate binding and proton release in a multidrug transporter. Proc Natl Acad Sci U S A, 2007. 104: p.17989-17994 .

  32. Reichel, A., Schaible, D., Al Furoukh, N., Cohen, M., Schreiber, G., and Piehler, J Noncovalent, site-specific biotinylation of histidine-tagged proteins. Anal Chem, 2007. 79: p.8590-8600 .

  33. Neuvirth, H., Heinemann, U., Birnbaum, D., Tishby, N., and Schreiber, G. ProMateus--an open research approach to protein-binding sites analysis. Nucleic Acids Res., 2007. 35: W543-8 .

  34. Harel, M., Cohen, M. & Schreiber, G. On the Dynamic Nature of the Transition State for Protein-Protein Association as Determined by Double-mutant Cycle Analysis and Simulation. J Mol. Biol., 2007. 371: p.180-96 .

  35. Hodis, E., Schreiber, G., Rother, K. & Sussman, J.L. eMovie: A storyboard-based tool for making molecular movies. TIBS, 2007. 32: p.199-204 .

  36. Jaitin, D. A. & Schreiber, G. Upregulation of a Small Subset of Genes Drives Type I Interferon-Induced Antiviral Memory. J Interferon Cytokine Res. 2007 27 p.653-664 .

  37. Kalie, E., Jaitin, D. A., Abramovich, R. & Schreiber, G. An IFNalpha 2 mutant optimized by phage-display for IFNAR1 binding confers specifically enhanced antitumor activities. J Biol Chem., 2007. 282: p.11602-11 .

  38. Reichmann, D., Rahat, O., Cohen, M., Neuvirth, H., & Schreiber, G. The molecular architecture of protein-protein binding sites. Curr Opin Struct Biol., 2007. 17: p. 67-76.

  39. Raveh, B., Rahat, O., Basri, R.& Schreiber, G. Rediscovering secondary structures as network motifs--an unsupervised learning approach. Bioinformatics, 2007. 23: p. e163-169.

  40. Kozer, N., Kuttner, Y.Y., Haran, G., & Schreiber, G. Protein-Protein Association in Polymer Solutions: From Dilute to Semidilute to Concentrated. Biophysical Journal, 2007. 92: p. 2139-2149.

  41. Reichmann, D., Cohen, M., Abramovich, R., Dym, O., Lim, D., Strynadka, JNC., & Schreiber, G. A Binding hot spots in the TEM1-BLIP interface in light of its modular architecture. J Mol Biol., 2007. 365: p. 663-679.

  42. Schmeisser, H., Kontsek, P., Esposito, D., Gillette, W., Schreiber, G., & Zoon, K. C. Binding Characteristics of IFN-alpha Subvariants to IFNAR2-EC and Influence of the 6-Histidine Tag. J Interferon Cytokine Res., 2006. 26: p. 866-876.

  43. Schreiber G, Shaul Y, Kottschalk KE Electrostatic design of protein-protein association rates. Methods Mol Biol 2006. 340: p. 235-49.

  44. Slutzki, M, Jaitin DA, Ben Yehezker, T, Schreiber G. Variations in the unstructured C-terminal tail of interferons contribute to differential receptor binding and bilogical activity. J Mol Biol 2006. 360: p. 119-30.

  45. Jaitin DA, Roisman LC, Jaks E, Gavutis M, Piehler J, Van der Heyden J, Uze G, Schreiber G. Inquiring into the Differential Action of Interferons (IFNs): an IFN-{alpha}2 Mutant with Enhanced Affinity to IFNAR1 Is Functionally Similar to IFN-{beta}. Mol Cell Biol 2006. 26: p. 1988-97.

  46. Schreiber G. The nitty-gritty of protein interactions. Structure 2005. 13: p. 1737-8.

  47. Kuttner YY, Kozer N, Segal E, Schreiber G, Haran G. Separating the contribution of translational and rotational diffusion to protein association. J Am Chem Soc 2005. 127: p. 15138-44.

  48. Albeck S, Burstein Y, Dym O, Jacobovitch Y, Levi N, Meged R, Michael Y, Peleg Y, Prilusky J, Schreiber G, Silman I, Unger T, Sussman JL. Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC). This paper was presented at ICCBM10. Acta Crystallogr D Biol Crystallogr 2005. 61: p. 1364-72.

  49. Shaul Y, Schreiber G. Exploring the charge space of protein-protein association: A proteomic study. Proteins 2005. 60: p. 341-52.

  50. Roisman LC, Jaitin DA, Baker DP, Schreiber G. Exploring the charge space of protein-protein association: A proteomic study. J Mol Biol 2005. 353: p. 271-81.

  51. Reichmann, D., Rahat, O., Albeck, S., Meged, R., Dym, O. & Schreiber, G. A The modular architecture of protein-protein binding interfaces. Proc Natl Acad Sci U S A., 2005. 102: p. 57-62.

  52. Gottschalk, K. E., Neuvirth, H. & Schreiber, G. A novel method for scoring of docked protein complexes using predicted protein-protein binding sites. Protein Eng Des Sel. 2004. 17: p. 183-189.

  53. Peleg-Shulman, T., Roisman, L. C., Zupkovitz, G. & Schreiber, G. Optimizing the Binding Affinity of a Carrier Protein: A CASE STUDY ON THE INTERACTION BETWEEN SOLUBLE ifnar2 AND INTERFERON {beta}. J Biol Chem. 2004. 279: p. 18046-18053.

  54. Kiel, C., Selzer, T., Shaul, Y., Schreiber, G. & Herrmann, C. Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex. Proc Natl Acad Sci U S A. 2004. 101(25): 9223-8.

  55. Kozer, N. & Schreiber, G. Effect of Crowding on Protein-Protein Association Rates: Fundamental Differences between Low and High Mass Crowding Agents. Journal of Molecular Biology. 2004. 336: p. 763-774.

  56. Neuvirth, H., Raz, R. & Schreiber, G. ProMate: A Structure Based Prediction Program to Identify the Location of Protein-Protein Binding Sites. J Mol Biol. 2004. 338: p. 181-199.

  57. Peleg-Shulman, Tsubery,T. Mironchik, M. Fridkin, M. Schreiber, G. and Shechter, Y. Reversible PEGylation: A novel technology to release native interferon a2 over a prolonged time period. J. Med. Chem. 2004. 279: p. 18046-18053.

  58. Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J. The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. Structure. 2003. 11: p. 791-802 .

  59. Chill, J.H., R. Nivasch, R. Levy, S. Albeck, G. Schreiber, and J. Anglister, The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening. Biochemistry, 2002. 41(11): p. 3575-85.

  60. Schreiber, G., Kinetic studies of protein-protein interactions. Curr Opin Struct Biol, 2002. 12(1): p. 41-7.

  61. Frisch, C., A.R. Fersht, and G. Schreiber, Experimental assignment of the structure of the transition state for the association of barnase and barstar. J Mol Biol, 2001. 308(1): p. 69-77.

  62. Piehler, J. and G. Schreiber, Fast transient cytokine-receptor interactions monitored in real time by reflectometric interference spectroscopy. Anal Biochem, 2001. 289(2): p. 173-86.

  63. Roisman, L.C., J. Piehler, J.Y. Trosset, H.A. Scheraga, and G. Schreiber, Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking. Proc Natl Acad Sci USA, 2001. 98(23): p. 13231-6.

  64. Schreiber, G., Methods for studying the interaction of barnase with its inhibitor barstar. Methods Mol Biol, 2001. 160: p. 213-26.

  65. Selzer, T. and G. Schreiber, New insights into the mechanism of protein-protein association. Proteins, 2001. 45(3): p. 190-8.

  66. Shechter, Y., L. Preciado-Patt, G. Schreiber, and M. Fridkin, Prolonging the half-life of human interferon-alpha 2 in circulation: Design, preparation, and analysis of (2-sulfo-9-fluorenylmethoxycarbonyl)7- interferon-alpha 2. Proc Natl Acad Sci USA, 2001. 98(3): p. 1212-7.

  67. Albeck, S., R. Unger, and G. Schreiber, Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges. J Mol Biol, 2000. 298(3): p. 503-20.

  68. Piehler, J., L.C. Roisman, and G. Schreiber, New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface. J Biol Chem, 2000. 275(51): p. 40425-33.

  69. Selzer, T., S. Albeck, and G. Schreiber, Rational design of faster associating and tighter binding protein complexes. Nat Struct Biol, 2000. 7(7): p. 537-41.

  70. Albeck, S. and G. Schreiber, Biophysical characterization of the interaction of the beta-lactamase TEM-1 with its protein inhibitor BLIP. Biochemistry, 1999. 38(1): p. 11-21.

  71. Piehler, J. and G. Schreiber, Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2. J Mol Biol, 1999. 289(1): p. 57-67.

  72. Piehler, J. and G. Schreiber, Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2. J Mol Biol, 1999. 294(1): p. 223-37.

  73. Selzer, T. and G. Schreiber, Predicting the rate enhancement of protein complex formation from the electrostatic energy of interaction. J Mol Biol, 1999. 287(2): p. 409-19.

  74. Vijayakumar, M., K.Y. Wong, G. Schreiber, A.R. Fersht, A. Szabo, and H.X. Zhou, Electrostatic enhancement of diffusion-controlled protein-protein association: comparison of theory and experiment on barnase and barstar. J Mol Biol, 1998. 278(5): p. 1015-24.

  75. Frisch, C., G. Schreiber, C.M. Johnson, and A.R. Fersht, Thermodynamics of the interaction of barnase and barstar: changes in free energy versus changes in enthalpy on mutation. J Mol Biol, 1997. 267(3): p. 696-706.

  76. Nolting, B., R. Golbik, J.L. Neira, A.S. Soler-Gonzalez, G. Schreiber, and A.R. Fersht, The folding pathway of a protein at high resolution from microseconds to seconds. Proc. Natl Acad Sci USA, 1997. 94(3): p. 826-30.

  77. Schreiber, G., C. Frisch, and A.R. Fersht, The role of Glu73 of barnase in catalysis and the binding of barstar. J Mol Biol, 1997. 270(1): p. 111-22.

  78. Gopalan V, Golbik R, Schreiber G, Fersht AR, Altman S, Fluorescence properties of a tryptophan residue in an aromatic core of the protein subunit of ribonuclease P from Escherichia coli. J Mol Biol, 1997. 267(1): p. 765-769.

  79. Schreiber, G. and A.R. Fersht, Rapid, electrostatically assisted association of proteins. Nat Struct Biol, 1996. 3(5): p. 427-31.

  80. Frisch, C., G. Schreiber, and A.R. Fersht, Characterization of in vitro oxidized barstar. FEBS Lett, 1995. 370(3): p. 273-7.

  81. Martinez, J.C., V.V. Filimonov, P.L. Mateo, G. Schreiber, and A.R. Fersht, A calorimetric study of the thermal stability of barstar and its interaction with barnase. Biochemistry, 1995. 34(15): p. 5224-33.

  82. Schreiber, G. and A.R. Fersht, Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles. J Mol Biol, 1995. 248(2): p. 478-86.

  83. Buckle, A.M., G. Schreiber, and A.R. Fersht, Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-A resolution. Biochemistry, 1994. 33(30): p. 8878-89.

  84. SCHREIBER G, RON EZ, GLASER G, PPGPP-MEDIATED REGULATION OF DNA-REPLICATION AND CELL-DIVISION IN ESCHERICHIA-COLI. CURRENT MICROBIOLOGY, 1995. 30(10): p. 27-32.

  85. AVIV M, GILADI H, SCHREIBER G, OPPENHEIM AB, GLASER G, EXPRESSION OF THE GENES-CODING FOR THE ESCHERICHIA-COLI INTEGRATION HOST FACTOR ARE CONTROLLED BY GROWTH-PHASE, RPOS, PPGPP AND BY AUTOREGULATION. MOLECULAR MICROBIOLOGY, 1994. 14(30): p. 1021-1031.

  86. Schreiber, G., A.M. Buckle, and A.R. Fersht, Stability and function: two constraints in the evolution of barstar and other proteins. Structure, 1994. 2(10): p. 945-51.

  87. Schreiber, G. and A.R. Fersht, Interaction of barnase with its polypeptide inhibitor barstar studied by protein engineering. Biochemistry, 1993. 32(19): p. 5145-50.

  88. Schreiber, G. and A.R. Fersht, The refolding of cis- and trans-peptidylprolyl isomers of barstar. JBC, 1991. 266: p. 3760-3767.

  89. SCHREIBER G, METZGER S, AIZENMAN E, ROZA S, CASHEL M, GLASER G, OVEREXPRESSION OF THE RELA GENE IN ESCHERICHIA-COLI. Biochemistry, 1993. 32(41): p. 11195-203.

  90. METZGER S, SCHREIBER G, AIZENMAN E, CASHEL M, GLASER G, CHARACTERIZATION OF THE RELA1 MUTATION AND A COMPARISON OF RELA1 WITH NEW RELA NULL ALLELES IN ESCHERICHIA-COLI. JBC, 1989. 264: p. 21146-21152.

  91. METZGER S, BENDROR I, AIZENMAN E, SCHREIBER G, TOONE M, FRIESEN JD, CASHEL M, GLASER G, THE NUCLEOTIDE-SEQUENCE AND CHARACTERIZATION OF THE RELA GENE OF ESCHERICHIA-COLI. JBC, 1988. 263: p. 15699-15704.

 Book Chapters
  1. Schreiber, G. (2001). Methods for Studying the Interaction of Barnase with Its Inhibitor Barstar, in Nuclease Methods and Protocols. C. H. Schein. New-York, Humana Press.

  2. Schreiber, G., (2002) Protein-protein interactions, in Biomolecular Sensors, E. Gizeli and R. Christopher, Editors. 2002, Taylor & Francis.

  3. Piehler, J. and Schreiber, G. (2004, 2009) Free energy landscapes in protein-protein interactions, in Handbook of Cellular Signalling, Bradshaw, R, and Dennis, E. Editors, Academic Press.

  4. Schreiber, G. (2009) The association of protein-protein complexes in Computational Protein-Protein Interactions, Nussinov R and Schreiber G. Editors, Taylor & Francis.

 Books
  • Nussinov, R and Schreiber, G. (2009) The association of protein-protein complexes .Editors, Taylor & Francis.