Department of biomolecular sciences

Structural Mass Spectrometry
Prof. Michal Sharon

Prof. Michal Sharon

Phone: +972-8-934-3947

Email: michal.sharon@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Sciences, Room 157
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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For Structural Mass Spectrometry

We aim to discover the mechanisms that control and coordinate the activity of molecular machines involved in the protein degradation pathway. To do so we apply novel native mass spectrometry approaches, in conjunction with fluorescence microscopy, biochemical and cell biology methods - generating an integrative mode of analysis combining in vitro and in vivo findings.

Protein-membrane interactions in health and disease
Prof. Yechiel Shai

Prof. Yechiel Shai

Phone: +972-8-934-2711

Fax: +972-8-934-4112

Email: yechiel.shai@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 206
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We study the interaction between peptides and proteins with and within the membrane milieu: These include: (1) selective cell destruction by innate immunity host defense antimicrobial peptides and lipopeptides future antibiotics; (2) the mechanism of HIV-cell fusion and how it evades the immune response; and (3) the role of transmembrane domains of cellular receptors (Toll-like receptors, TCR, ErB) in their proper signaling.

Functional reprogramming in the tumor microenvironment
Dr. Ruth Scherz-Shouval

Dr. Ruth Scherz-Shouval

Phone: +972-8-934-2299

Email: ruth.shouval@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 280
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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 For functional reprogramming in the tumor microenvironment

For tumors to expand, metastasize, and evade immune surveillance, genetically transformed cancer cells must recruit non-malignant cells, including macrophages, fibroblasts and endothelial cells. These cells, collectively termed the tumor microenvironment, are reprogrammed to support the tumor at the expense of its host. Our group aims to elucidate the mechanisms by which tumors reprogram their local environments. Our goal is to provide a deeper understanding of how tumors develop into systemic malignancies, predict which tumors are more likely to do so, and design therapeutic strategies to overcome these malignancies by targeting genetically stable elements in the tumor microenvironment.

Multienzyme Cellulosomes for Alternative Energy Research
Prof. Ed Bayer

Prof. Ed Bayer

Phone: +972-8-934-2373

Fax: +972-8-934-8256

Email: ed.bayer@weizmann.ac.il

 

Location: Ullmann Building of Life Sciences, Room Room 226
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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Our studies focus on all aspects of the multi-enzyme cellulosome complex, which is considered the elite enzymatic system for conversion of cellulose and associated plant polysaccharides to simple sugars en route to biofuels, such as ethanol. For this purpose, we employ an array of multi-disciplinary strategies, including bioinformatics, genomics, biochemical and biophysical approaches, structure studies, and the fabrication of artificial “designer cellulosomes”.

Mechanisms of Neuronal Wiring
Prof. Avraham Yaron

Prof. Avraham Yaron

Phone: +972-8-934-6240

Email: avraham.yaron@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 406
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We are investigating the mechanisms that govern the wiring of the nervous system during development, which includes axonal guidance, pruning and the role of local protein synthesis.

How can cells measure themselves?
Prof. Michael Fainzilber

Prof. Michael Fainzilber

Phone: +972-8-934-4266

Fax: +972-8-934-4112

Email: mike.fainzilber@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 405
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We are investigating long distance signaling mechanisms in neurons and other large eukaryotic cells, primarily an importins/molecular motor-based mechanism that integrates cytoplasmic and nuclear signaling. Currently our main focus is on the roles of this and related mechanisms in neuronal responses to injury and in cellular length sensing.

Decoding gene regulatory commands
Prof. Rivka Dikstein

Prof. Rivka Dikstein

Phone: +972-8-934-2117

Email: rivka.dikstein@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 329
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We are studying regulation of transcription and translation in health and disease. Specifically we investigate the mechanism underlying rapid transcriptional induction of NF-kappaB target genes, we analyze newly identified links between transcription, mRNA processing and translation and we study transcriptional control of microRNA genes and of embryonic stem cells.

Linking pancreatic beta cells and diabetes
Prof. Michael Walker
Walker Michael

Prof. Michael Walker

Phone: +972-8-934-3597

Fax: +972-8-934-4118

Email: m.walker@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 330
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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The focus of our research is the beta cell of the pancreas.

We are interested in elucidating the mechanisms that control its unique ability to produce and secrete insulin in response to physiological stimuli, and in identifying the defects in this process that can lead to diabetes.

Reproducing de novo protein emergence
Prof. Dan Tawfik
Tawfik Dan

Prof. Dan Tawfik

Phone: +972-8-934-3637

Fax: +972-8-934-4118

Email: dan.tawfik@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 177
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We study the structure and function of proteins, and of enzymes in particular, and how they evolve. To this end, we reproduce the evolutionary process of mutation and selection to generate proteins with new functions and structures.

Computational Design of New Protein Functions
Dr. Sarel-Jacob Fleishman
Fleishman Sarel-Jacob

Dr. Sarel-Jacob Fleishman

Phone: +972-8-934-6361

Email: sarel.fleishman@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 479
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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Dr. Sarel-Jacob Fleishman

We are interested in how protein function is encoded in the structures of protein binders, enzymes, and antibodies. To test our understanding we computationally design new protein functions not seen in Nature and experimentally characterize these designs. Iterations of design and experimental characterization enable us to understand new features of how protein function is specified in Nature.

Circadian Rhythms in Health & Disease
Dr. Gad Asher

Dr. Gad Asher

Phone: +972-8-934-6949

Fax: +972-8-934-6010

Email: gad.asher@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 277
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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Our main research interest is to explore the interplay between the cellular metabolic state and circadian clocks and further identify the underling molecular mechanisms.

Human diseases involving sphingolipids
Prof. Anthony H. Futerman

Prof. Anthony H. Futerman

Phone: +972-8-934-2704

Fax: +972-8-934-4112

Email: tony.futerman@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 456
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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Our laboratory works on sphingolipids, important membrane components. We focus on two main areas: (i) sphingolipid synthesis and signaling, particularly of ceramide, and (ii) sphingolipid storage diseases, with an emphasis on mechanistic understanding of disease pathology and also on novel therapeutic approaches.

Protein Interactions in vitro and in vivo
Prof. Gideon Schreiber
Schreiber Gideon

Prof. Gideon Schreiber

Phone: +972-8-934-3249

Email: gideon.schreiber@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 475
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We study the basic physico-chemical principles governing the kinetics, thermodynamics and specificity of protein-protein interactions. The gained knowledge is translated into the development and implementation of protein engineering methodologies. Between other, these are used to study how the interaction of interferon with its receptors results in complex differential responses in cells.

Malaria parasite biological aspects
Dr. Neta Regev-Rudzki

Dr. Neta Regev-Rudzki

Phone: +972-8-934-3160

Email: neta.regev-rudzki@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Sciences, Room 205
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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With malaria continuing to be a major global disease, advances toward understanding the basic biology of P. falciparum remain essential. Our studies focus on different aspects of the cellular biology of the malaria parasite. In particular, we aim to explore cell-cell communication pathways between the parasites themselves and their human host.

Autophagy in health and disease
Prof. Zvulun Elazar

Prof. Zvulun Elazar

Phone: +972-8-934-3682

Email: zvulun.elazar@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 358
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We study the molecular mechanism and regulation of autophagy, a process responsible for the degradation of cytoplasmic proteins and organelles. A particular emphasis is given to the relationship of this catabolic pathway to disease such as cancer and neurodegeneration.

Membrane proteins: biogenesis, structure and function
Prof. Eitan Bibi

Prof. Eitan Bibi

Phone: +972-8-934-6435

Fax: +972-8-934-6334

Email: e.bibi@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 376
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We ask how cells produce membrane proteins and how various structural determinants affect their function: (i) How ribosomes and mRNAs target the membrane, where localized translation of membrane proteins occurs. (ii) What dictates the fascinating capabilities of multidrug transporters and the multidrug-efflux phenomenon.

Ion channels and cellular physiology
Prof. Eitan Reuveny

Prof. Eitan Reuveny

Phone: +972-8-934-3243

Fax: +972-8-934-2135

Email: e.reuveny@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 356
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We are interested in deciphering the mechanisms by which extracellular and intracellular signaling queues affect ion channel function, both in excitable and non-excitable tissues. We focus on three main areas: 1) GPCRs-mediated ion channel regulation and modulation, 2) cellular mechanisms that control calcium homeostasis, 3) how physiological functions are affected by ions channels activity.

Cell-death proteins in disease
Prof. David Wallach
Wallach David

Prof. David Wallach

Phone: +972-8-934-3941

Fax: +972-8-934-3165

Email: d.wallach@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Sciences, Room 430
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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embryo mouse

Studies in our laboratory aim towards elucidating the signaling mechanisms that mediate two cardinal activities of cytokines of the TNF family: induction of programmed cell death, and activation of transcription factors such as NF-kappa B that participate in the induction of immune defense mechanisms.

Na,K-ATPase: no life without it.
Prof. Steven J.d Karlish
Karlish Steven J.d

Prof. Steven J.d Karlish

Email: steven.karlish@weizmann.ac.il

 

Location: Ullmann Building of Life Sciences, Room 334A
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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DNA damage repair, genetic stability & cancer
Prof. Zvi Livneh

Prof. Zvi Livneh

Phone: +972-8-934-3203

Fax: +972-8-934-4169

Email: zvi.livneh@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 307
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We are studying molecular mechanisms of DNA repair, and in particular error-prone repair (translesion DNA synthesis) in mammalian cells. In addition, we employ the knowledge on DNA repair to develop novel functional enzymatic DNA repair biomarkers for risk assessment and prevention of cancer.

Bacterial & mammalian sperm guidance.
Prof. Michael Eisenbach
Eisenbach Michael

Prof. Michael Eisenbach

Phone: +972-8-934-3923

Fax: +972-8-934-2722

Email: m.eisenbach@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 308
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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Bacterial chemotaxis & mammalian sperm guidance

Survivability and variability in photosynthesis: From machines to communities
Prof. Ziv Reich
Reich Ziv

Prof. Ziv Reich

Phone: +972-8-934-2982

Email: ziv.reich@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 259
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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We are interested in transport processes and in photosynthesis. Within the realm of photosynthesis we are mainly concerned with dynamic processes that accompany the life cycle of the thylakoid network, including its response to different stresses and its formation and dismantling. Regarding nucleo-cytoplasmic transport, we are particularly interested in its selectivity, the behavior of the ensemble of transporting molecules as it relates to the transport of a single molecule and in applications to gene therapy. In both fields of study, we combine different approaches and methodologies including ensemble and single-molecule biophysical methods, biochemical and molecular biology techniques, statistical mechanical modeling and state-of-the-art electron microscopy.

The architecture of cell membranes
Dr. Ori Avinoam

Dr. Ori Avinoam

Phone: +972-8-934-3557

Email: ori.avinoam@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 374
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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The architecture of cell membranes

We are interested in the universal process of membrane remodeling that occurs during endocytosis, when subdomains of the membrane are reshaped into cargo transport vesicles, which allow cells to take up material and communicate with the environment. Our studies focus on understanding the molecular mechanisms of endocytosis and their contribution to cell physiology. We use a combination of advanced imaging techniques that include correlated light and electron microscopy to visualize these processes with high spatial and temporal resolution. We are particularly interested in understanding how endocytic processes contribute to muscle differentiation and homeostasis.

Prof. Yoav Soen

Prof. Yoav Soen

Phone: +972-8-934-6011

Email: yoavs@weizmann.ac.il

 

Location: Nella and Leon Benoziyo Building for Biological Chemistry, Room 229
Weizmann Institute of Science,
Rehovot 76100, Israel

 

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Prof. Yoav Soen

We study epigenetic mechanisms by which developmental plasticity allows the environment to bring about heritable modifications in the developmental program. We approach this with a combination of in vitro (mammalian cells) and in vivo models (the fly, D. melanogaster), in which we confront developmental processes with unforeseen environmental challenges that promote deviations from the selected patterns of development.